New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis

Kothapalli, 2020, Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19, Prostaglandins Leukot Essent Fatty Acids, 162, 102183, 10.1016/j.plefa.2020.102183

Doll, 2017, ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition, Nat Chem Biol, 13, 91, 10.1038/nchembio.2239

Hale, 2019, Acyl-CoA synthetase 6 enriches seminiferous tubules with the omega-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse, J Biol Chem, 294, 14394, 10.1074/jbc.RA119.009972

Fernandez, 2021, Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging, JCI Insight, 6, e144351, 10.1172/jci.insight.144351

Garcia, 2018, Conversion of dietary trans-vaccenic acid to trans11,cis13-conjugated linoleic acid in the rat lactating mammary gland by fatty acid desaturase 3-catalyzed methyl-end Delta13-desaturation, Biochem Biophys Res Commun, 505, 385, 10.1016/j.bbrc.2018.09.132

Zhang, 2017, Fads3 modulates docosahexaenoic acid in liver and brain, Prostaglandins Leukot Essent Fatty Acids, 123, 25, 10.1016/j.plefa.2017.07.001

Karsai, 2020, FADS3 is a Delta14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome, J Biol Chem, 295, 1889, 10.1074/jbc.AC119.011883

Park, 2018, The role of fatty acid desaturase (FADS) genes in oleic acid metabolism: FADS1 Delta7 desaturates 11-20:1 to 7,11-20:2, Prostaglandins Leukot Essent Fatty Acids, 128, 21, 10.1016/j.plefa.2017.11.004

Trevizan, 2012, Maintenance of arachidonic acid and evidence of delta 5 desaturation in cats fed gamma-linolenic and linoleic acid enriched diets, Lipids, 47, 413, 10.1007/s11745-011-3651-0

Li, 2018, A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study, Am J Clin Nutr, 107, 867, 10.1093/ajcn/nqy063

Rahbar, 2018, Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes, Clin Epigenetics, 10, 46, 10.1186/s13148-018-0480-5

Park, 2009, An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3, J Lipid Res, 50, 1195, 10.1194/jlr.M800630-JLR200

Park, 2015, The fatty acid desaturase 2 (FADS2) gene product catalyzes Delta4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells, FASEB J, 29, 3911, 10.1096/fj.15-271783

Oboh, 2017, Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish, Sci Rep, 7, 3889, 10.1038/s41598-017-04288-2

Metherel, 2019, Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat, J Lipid Res, 60, 412, 10.1194/jlr.M090373

Park, 2016, Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 alpha-linolenic acids for FADS2 mediated Delta 6-desaturation, Biochim Biophys Acta, 1861, 91, 10.1016/j.bbalip.2015.11.007

Snaebjornsson, 2019, Tumours use a metabolic twist to make lipids, Nature, 566, 333, 10.1038/d41586-019-00352-1

Vriens, 2019, Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity, Nature, 566, 403, 10.1038/s41586-019-0904-1

Wang, 2020, Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids, Biochim Biophys Acta Mol Cell Biol Lipids, 1865, 158572, 10.1016/j.bbalip.2019.158572

Brenna, 2010, Alternative transcripts of fatty acid desaturase (FADS) genes, Prostaglandins Leukot Essent Fatty Acids, 82, 281, 10.1016/j.plefa.2010.02.011

Kothapalli, 2018, A novel FADS2 isoform identified in human milk fat globule suppresses FADS2 mediated Delta6-desaturation of omega-3 fatty acids, Prostaglandins Leukot Essent Fatty Acids, 138, 52, 10.1016/j.plefa.2018.06.004

Hopiavuori, 2019, ELOVL4: very long-chain fatty acids serve an eclectic role in mammalian health and function, Prog Retin Eye Res, 69, 137, 10.1016/j.preteyeres.2018.10.004

Gonzalez-Soto, 2021, Diet regulation of long-chain PUFA synthesis: role of macronutrients, micronutrients, and polyphenols on Delta-5/Delta-6 desaturases and elongases 2/5, Adv Nutr, 12, 980, 10.1093/advances/nmaa142

Simpson, 2021, Epigenetic age prediction, Aging Cell, 20, e13452, 10.1111/acel.13452

Marquez-Ruiz, 2020, DNA methylation levels and telomere length in human teeth: usefulness for age estimation, Int J Legal Med, 134, 451, 10.1007/s00414-019-02242-7

Slieker, 2018, Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception, Epigenetics Chromatin, 11, 25, 10.1186/s13072-018-0191-3

Barros-Filho, 2018, Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas, Oral Oncol, 83, 81, 10.1016/j.oraloncology.2018.06.010

Zhang, 2020, Mutational characterization and potential prognostic biomarkers of Chinese patients with esophageal squamous cell carcinoma, Onco Targets Ther, 13, 12797, 10.2147/OTT.S275688

Park, 2021, The aromatase inhibitor letrozole restores FADS2 function in ER+ MCF7 human breast cancer cells, Prostaglandins Leukot Essent Fatty Acids, 171, 102312, 10.1016/j.plefa.2021.102312

Park, 2018, A rare eicosanoid precursor analogue, sciadonic acid (5Z,11Z,14Z-20:3), detected in vivo in hormone positive breast cancer tissue, Prostaglandins Leukot Essent Fatty Acids, 134, 1, 10.1016/j.plefa.2018.05.002

Young, 2021, Apocryphal FADS2 activity promotes fatty acid diversification in cancer, Cell Rep, 34, 108738, 10.1016/j.celrep.2021.108738

Lee, 2020, FADS2-mediated fatty acid desaturation and cholesterol esterification are signatures of metabolic reprogramming during melanoma progression, bioRXiv

Korbecki, 2020, Expression of SCD and FADS2 is lower in the necrotic core and growing tumor area than in the peritumoral area of glioblastoma multiforme, Biomolecules, 10, 727, 10.3390/biom10050727

de Fraipont, 2019, Circular RNAs and RNA splice variants as biomarkers for prognosis and therapeutic response in the liquid biopsies of lung cancer patients, Front Genet, 10, 390, 10.3389/fgene.2019.00390

Zhao, 2018, circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498, Biosci Rep, 38, BSR20180570, 10.1042/BSR20180570

Xiao, 2020, CircFADS2: a potential prognostic biomarker of colorectal cancer, Exp Biol Med (Maywood), 245, 1233, 10.1177/1535370220929965

Lee, 2020, Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer, Proc Natl Acad Sci USA, 117, 32433, 10.1073/pnas.2006828117

Larsson, 2021, Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK biobank and genetic consortia participants: a mendelian randomization study, Clin Nutr, 40, 3332, 10.1016/j.clnu.2020.11.004

Wang, 2019, Cross-cancer pleiotropic analysis reveals novel susceptibility loci for lung cancer, Front Oncol, 9, 1492, 10.3389/fonc.2019.01492

Lu, 2020, FADS1 is a prognostic biomarker in bladder cancer: a study based on TCGA data, Comb Chem High Throughput Screen, 24, 1197, 10.2174/1386207323666200925104911

Jiao, 2020, Identification of FADS1 through common gene expression profiles for predicting survival in patients with bladder cancer, Cancer Manag Res, 12, 8325, 10.2147/CMAR.S254316

Jeong, 2021, ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancer, Am J Cancer Res, 11, 2568

Kang, 2019, Spheroid-induced epithelial-mesenchymal transition provokes global alterations of breast cancer lipidome: a multi-layered omics analysis, Front Oncol, 9, 145, 10.3389/fonc.2019.00145

Rugolo, 2021, The expression of ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome, Oncogene, 40, 5741, 10.1038/s41388-021-01959-3

Tomida, 2021, Plasmalogen deficiency and overactive fatty acid elongation biomarkers in serum of breast cancer patients pre- and post-surgery – new insights on diagnosis, risk assessment, and disease mechanisms, Cancers (Basel), 13, 4170, 10.3390/cancers13164170

Zhang, 2016, Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis, Curr Opin Clin Nutr Metab Care, 19, 103, 10.1097/MCO.0000000000000254

Deak, 2019, Novel cellular functions of very long chain-fatty acids: insight from ELOVL4 mutations, Front Cell Neurosci, 13, 428, 10.3389/fncel.2019.00428

Park, 2011, FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids, PLoS One, 6, e28186, 10.1371/journal.pone.0028186