Current Opinion in Clinical Nutrition and Metabolic Care
1363-1950
1535-3885
Mỹ
Cơ quản chủ quản: LIPPINCOTT WILLIAMS & WILKINS , Lippincott Williams and Wilkins Ltd.
Phân tích ảnh hưởng
Thông tin về tạp chí
Lĩnh vực:
Nutrition and DieteticsMedicine (miscellaneous)
A high impact review journal which boasts an international readership, Current Opinion in Clinical Nutrition and Metabolic Care offers a broad-based perspective on the most recent and exciting developments within the field of clinical nutrition and metabolic care. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include protein, amino acid metabolism and therapy, lipid metabolism and therapy, nutrition and the intensive care unit and carbohydrates. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
The risks of free copper in the body and the development of useful anticopper drugs
Tập 11 Số 6 - Trang 727-732 - 2008
New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis
Purpose of review
Molecular studies have clarified the roles of the fatty acid desaturase (FADSx ) and elongation of very long chain fatty acid (ELOVLx ) genes, as well as acyl-coenzyme A synthase long-chain isoforms (ACSLx ) required for entry to long-chain polyunsaturated fatty acid (LCPUFA) biosynthetic pathways.
Recent findings
FADS1 and FADS2 but not FADS3 are active toward PUFA. FADS1 is a Δ5-desaturase operating on five C20 PUFA, and is strongly regulated by human genetic polymorphisms, modulating circulating arachidonic acid (20:4n -6) levels. In contrast, FADS2 operates on at least 16 substrates, including five saturates, and catalyzes Δ6, Δ4, and Δ8 desaturation. FADS2 silencing in cancer cells leads to FADS1 synthesis of unusual fatty acids. ACSL6 and ACSL4 are required to maintain tissue 22:6n -3 and 20:4n -6, respectively. FADS2AT2, is the first transcript to differentially inhibit desaturation, attenuating 18:3n -3 but not 18:2n -6 desaturation. The PUFA elongases ELOVL5, 2, and 4 are implicated in cancer, age-related methylation, and retinal degeneration, respectively.
Summary
The mixture of fatty acids available to FADS2 in any tissue defines the product mixture available for further synthesis of membrane lipids and signaling molecules and may be relevant in many clinical conditions including cancer. Functional genetic variants define the levels of circulating arachidonic acid via FADS1 regulation; genotypes that drive high arachidonic acid may predispose to disease.
Tập 25 Số 2 - Trang 60-66 - 2022
Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance
Tập 20 Số 1 - Trang 92-98 - 2017
Current understanding of the metabolism and biological actions of HDL
Tập 8 Số 2 - Trang 147-152 - 2005
Zinc: role in immunity, oxidative stress and chronic inflammation
Tập 12 Số 6 - Trang 646-652 - 2009