New insights into the burden and costs of multiple sclerosis in Europe: Results for Italy

Multiple Sclerosis Journal - Tập 23 Số 2_suppl - Trang 104-116 - 2017
Mario Alberto Battaglia1, Gisela Kobelt2, Michela Ponzio3, Jenny Berg4, Daniela Capsa4, Johan Dalén4
1Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Genoa, Italy/Department of Life Sciences, The University of Siena, Siena, Italy
2European Health Economics, Mulhouse, France
3Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Genoa, Italy
4Mapi Group, Stockholm, Sweden

Tóm tắt

Introduction: In order to estimate the value of interventions in multiple sclerosis (MS) – where lifetime costs and outcomes cannot be observed – outcome data have to be combined with costs. This requires that cost data be regularly updated. Objectives and methods: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS. Descriptive analyses are presented by level of severity, from the societal perspective, in EUR 2015. Results: A total of 1010 patients (mean age = 45 years) participated in Italy. In total, 94% were below retirement age, and of these, 56% were employed. Employment was related to disability, and MS affected productivity at work in 77% of the patients. Overall, 96% and 65% of the patients experienced fatigue and cognitive difficulties as a problem, respectively. Mean utility and total annual costs were 0.735 and €22,900 at Expanded Disability Status Scale (EDSS) of 0–3, 0.534 and €40,100 at EDSS of 4–6.5, and 0.135 and €53,300 at EDSS of 7–9. The mean cost of a relapse was estimated to be €2600. Conclusion: This study illustrates the burden of MS on Italian patients and provides current data on MS that are important for the development of health policies.

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