New insights into human enteric neuropathies

Neurogastroenterology and Motility - Tập 16 Số s1 - Trang 143-147 - 2004
Roberto De Giorgio1, Stefania Guerrini1, Giovanni Barbara1, Cesare Cremon1, Vincenzo Stanghellini1, Roberto Corinaldesi1
1Department of Internal Medicine & Gastroenterology, University of Bologna, Bologna, Italy

Tóm tắt

AbstractThe functioning of enteric neuronal circuitries has been elucidated in the recent past. Evidence is now gathering to explain how dysfunction of the enteric nervous system (ENS) may lead to human gastrointestinal motor disorders. These conditions include achalasia, congenital hypertrophic pyloric stenosis, chronic intestinal pseudo‐obstruction, Hirschsprung's disease, chronic idiopathic constipation, and probably irritable bowel syndrome. Degenerative, inflammatory and genetic mechanisms exert a critical role in ENS dysfunction underlying gut dysmotility. The study of the ENS abnormalities in gut dysmotility provides a framework to better understand the mechanisms involved in degeneration and neuronal loss and fosters the development of targeted therapeutic options.

Từ khóa


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Neurogastroenterology and Motility

Tập 16 Số s1

143-147

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