New insights into epididymal function in relation to sperm maturation

Reproduction - Tập 147 Số 2 - Trang R27-R42 - 2014
Jean‐Louis Dacheux1, Françoise Dacheux2
1UMR INRA-CNRS 7247, 37380 Nouzilly, France.
2UMR INRA-CNRS 724737380 Nouzilly, France

Tóm tắt

Testicular spermatozoa acquire fertility only after 1 or 2 weeks of transit through the epididymis. At the end of this several meters long epididymal tubule, the male gamete is able to move, capacitate, migrate through the female tract, bind to the egg membrane and fuse to the oocyte to result in a viable embryo. All these sperm properties are acquired after sequential modifications occurring either at the level of the spermatozoon or in the epididymal surroundings. Over the last few decades, significant increases in the understanding of the composition of the male gamete and its surroundings have resulted from the use of new techniques such as genome sequencing, proteomics combined with high-sensitivity mass spectrometry, and gene-knockout approaches. This review reports and discusses the most relevant new results obtained in different species regarding the various cellular processes occurring at the sperm level, in particular, those related to the development of motility and egg binding during epididymal transit.

Từ khóa


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