Những hướng đi mới trong điều trị bệnh tim mạch đi kèm ở bệnh phổi tắc nghẽn mãn tính
Tóm tắt
Bệnh phổi tắc nghẽn mãn tính (COPD) là một căn bệnh được đặc trưng bởi sự hạn chế lưu lượng không khí kéo dài không thể đảo ngược hoàn toàn và hiện là nguyên nhân gây tử vong hàng thứ tư trên toàn cầu. Hiện nay, đã được xác nhận rằng các bệnh lý tim mạch liên quan góp phần gây ra bệnh tật và tử vong ở bệnh nhân COPD, với khoảng 50% số ca tử vong ở bệnh nhân COPD được cho là do các biến cố tim mạch (ví dụ: nhồi máu cơ tim). Bệnh tim mạch (CVD) và COPD chia sẻ nhiều yếu tố nguy cơ khác nhau bao gồm tăng huyết áp, ít vận động, hút thuốc và chế độ ăn uống kém, nhưng các cơ chế cơ bản vẫn chưa được thiết lập hoàn toàn. Tuy nhiên, có những bằng chứng thí nghiệm và lâm sàng ngày càng rõ ràng cho thấy căng thẳng oxy hóa gây ra viêm phổi và sự tràn ngập của các chất trung gian pro-inflammatory từ phổi vào tuần hoàn hệ thống dẫn đến một phản ứng viêm hệ thống kéo dài, làm thay đổi cấu trúc mạch máu, thông qua việc tái tạo mạch máu và độ cứng động mạch, dẫn đến xơ vữa động mạch. Ngoài ra, sự điều chỉnh các chất hoạt tính vaso từ nội mô (ví dụ: nitric oxide (NO)), kiểm soát trương lực mạch máu cũng bị thay đổi bởi tổn thương oxy hóa của các tế bào nội mô mạch, do đó thúc đẩy rối loạn chức năng mạch máu, một yếu tố chính thúc đẩy CVD. Trong bài tổng quan này, vai trò có hại của căng thẳng oxy hóa trong COPD và CVD đi kèm được thảo luận và chúng tôi đề xuất rằng việc nhắm đến các cơ chế phụ thuộc vào oxy hóa là một chiến lược mới trong điều trị CVD liên quan đến COPD.
Từ khóa
#COPD #bệnh tim mạch #căng thẳng oxy hóa #viêm phổi #điều trị CVDTài liệu tham khảo
Australia, T.L.F., 2017, COPD: The Statistics
Xiong, 2017, Can we predict the prognosis of COPD with a routine blood test?, Int. J. Chron. Obstruct. Pulmon. Dis., 12, 615, 10.2147/COPD.S124041
WHO, 2018, The Top 10 Causes of Death
Drost, 2005, Oxidative stress and airway inflammation in severe exacerbations of COPD, Thorax, 60, 293, 10.1136/thx.2004.027946
Thomsen, 2013, Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease, JAMA, 309, 2353, 10.1001/jama.2013.5732
Guarascio, 2013, The clinical and economic burden of chronic obstructive pulmonary disease in the USA, Clinicoecon Outcomes Res., 5, 235
European Respiratory Society, 2011, The economic burden of lung disease, European Lung Whitebook
Vogelmeier, 2017, Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary, Am. J. Respir. Crit. Care Med., 195, 557, 10.1164/rccm.201701-0218PP
Bathoorn, 2008, Anti-inflammatory effects of combined budesonide/formoterol in COPD exacerbations, COPD, 5, 282, 10.1080/15412550802363360
Curkendall, 2006, Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients, Ann. Epidemiol., 16, 63, 10.1016/j.annepidem.2005.04.008
Magnussen, 2014, Withdrawal of inhaled glucocorticoids and exacerbations of COPD, N. Engl. J. Med., 371, 1285, 10.1056/NEJMoa1407154
Peinado, 1998, Endothelial dysfunction in pulmonary arteries of patients with mild COPD, Am. J. Physiol. Lung Cell. Mol. Physiol., 274, L908, 10.1152/ajplung.1998.274.6.L908
Perera, 2007, Inflammatory changes, recovery and recurrence at COPD exacerbation, Eur. Respir. J., 29, 527, 10.1183/09031936.00092506
Vlahos, 2014, Recent advances in pre-clinical mouse models of COPD, Clin. Sci., 126, 253, 10.1042/CS20130182
Vignola, 2004, Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD, Eur. Respir. J., 24, 910, 10.1183/09031936.04.00032603
Barnes, 2016, Inflammatory mechanisms in patients with chronic obstructive pulmonary disease, J. Allergy Clin. Immunol., 138, 16, 10.1016/j.jaci.2016.05.011
Mackay, 2013, COPD exacerbations: causes, prevention, and treatment, Immunol. Allergy Clin. North Am., 33, 95, 10.1016/j.iac.2012.10.006
MacIntyre, 2008, Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease, Proc. Am. Thorac. Soc., 5, 530, 10.1513/pats.200707-088ET
Lipson, 2018, Once-daily single-inhaler triple versus dual therapy in patients with COPD, N. Engl. J. Med., 378, 1671, 10.1056/NEJMoa1713901
Choi, 2016, Prevalence of bacterial and viral infections in acute exacerbation of chronic obstructive pulmonary disease in single center in South Korea, Am. Thorac. Soc., 193, A5178
Charlson, 2010, Disordered microbial communities in the upper respiratory tract of cigarette smokers, PLoS ONE, 5, e15216, 10.1371/journal.pone.0015216
Sze, 2014, Bacterial microbiome of lungs in COPD, Int. J. Chron. Obstruct. Pulmon. Dis., 9, 229
Hilty, 2010, Disordered microbial communities in asthmatic airways, PLoS ONE, 5, e8578, 10.1371/journal.pone.0008578
Pragman, 2012, The lung microbiome in moderate and severe chronic obstructive pulmonary disease, PLoS ONE, 7, e47305, 10.1371/journal.pone.0047305
Wang, 2018, Resolving viral-induced secondary bacterial infection in COPD: a concise review, Front. Immunol., 9, 2345, 10.3389/fimmu.2018.02345
Celli, 2012, Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 185, 1065, 10.1164/rccm.201110-1792OC
Wouters, 2009, Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?, Proc. Am. Thorac. Soc., 6, 638, 10.1513/pats.200907-073DP
Barnes, 2010, Chronic obstructive pulmonary disease: effects beyond the lungs, PLoS Med., 7, e1000220, 10.1371/journal.pmed.1000220
de Moraes, 2014, Interleukin-6 and interleukin-8 blood levels’ poor association with the severity and clinical profile of ex-smokers with COPD, Int. J. Chron. Obstruct. Pulmon. Dis., 9, 735
Gaki, 2011, Associations between BODE index and systemic inflammatory biomarkers in COPD, J. Chron. Obstruct. Pulmon. Dis., 8, 408, 10.3109/15412555.2011.619599
Hartjes, 2018, Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD, Respirology, 23, 1023, 10.1111/resp.13312
Barnes, 2018, Targeting cytokines to treat asthma and chronic obstructive pulmonary disease, Nat. Rev. Immunol., 18, 454, 10.1038/s41577-018-0006-6
(GOLD), G.I.f.C.O.P.D., 2018, Annual report, Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (GOLD)
Sapey, 2011, Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 183, 1176, 10.1164/rccm.201008-1285OC
Stanescu, 1996, Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils, Thorax, 51, 267, 10.1136/thx.51.3.267
O’Donnell, 2004, Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD, Thorax, 59, 837, 10.1136/thx.2003.019349
Vlahos, 2012, Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD, PLoS ONE, 7, e33277, 10.1371/journal.pone.0033277
Barnes, 2009, Role of HDAC2 in the pathophysiology of COPD, Annu. Rev. Physiol., 71, 451, 10.1146/annurev.physiol.010908.163257
George, 2016, Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease, Ther. Adv. Chronic. Dis., 7, 34, 10.1177/2040622315609251
Barnes, 2013, Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease, J. Allergy Clin. Immunol., 131, 636, 10.1016/j.jaci.2012.12.1564
Keatings, 1996, Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma, Am. J. Respir. Crit. Care Med., 153, 530, 10.1164/ajrccm.153.2.8564092
Long, 2018, Precision medicine in COPD: review of mepolizumab for eosinophilic COPD, Breathe (Sheff.), 14, 338, 10.1183/20734735.026318
Brightling, 2005, Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease, Thorax, 60, 193, 10.1136/thx.2004.032516
Brightling, 2000, Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial, Lancet, 356, 1480, 10.1016/S0140-6736(00)02872-5
Leigh, 2006, Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment, Eur. Respir. J., 27, 964, 10.1183/09031936.06.00072105
Pizzichini, 1998, Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis, Am. J. Respir. Crit. Care Med., 158, 1511, 10.1164/ajrccm.158.5.9804028
Bafadhel, 2018, Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials, Lancet Respir. Med., 6, 117, 10.1016/S2213-2600(18)30006-7
Casanova, 2017, Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD, Eur. Respir. J., 50, 1701162, 10.1183/13993003.01162-2017
Yun, 2018, Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease, J. Allergy Clin. Immunol., 141, 2037, 10.1016/j.jaci.2018.04.010
Bafadhel, 2012, Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial, Am. J. Respir. Crit. Care Med., 186, 48, 10.1164/rccm.201108-1553OC
Rahman, 1996, Systemic oxidative stress in asthma, COPD, and smokers, Am. J. Respir. Crit. Care Med., 154, 1055, 10.1164/ajrccm.154.4.8887607
Drost, 2005, Oxidative stress and airway inflammation in severe exacerbations of COPD, Thorax, 60, 293, 10.1136/thx.2004.027946
Austin, 2016, COPD and stroke: are systemic inflammation and oxidative stress the missing links?, Clin. Sci., 130, 1039, 10.1042/CS20160043
Bernardo, 2015, Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities, Pharmacol. Ther., 155, 60, 10.1016/j.pharmthera.2015.08.005
Vlahos, 2014, NADPH oxidases as novel pharmacologic targets against influenza A virus infection, Mol. Pharmacol., 86, 747, 10.1124/mol.114.095216
Passey, 2016, Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease, Pharmacol. Ther., 166, 56, 10.1016/j.pharmthera.2016.06.013
Selemidis, 2008, NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition, Pharmacol. Ther., 120, 254, 10.1016/j.pharmthera.2008.08.005
Drummond, 2011, Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets, Nat. Rev. Drug Discov., 10, 453, 10.1038/nrd3403
Tuder, 2003, Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade, Am. J. Respir. Cell Mol. Biol., 29, 88, 10.1165/rcmb.2002-0228OC
Rahman, 2006, Oxidative stress and redox regulation of lung inflammation in COPD, Eur. Respir. J., 28, 219, 10.1183/09031936.06.00053805
Mak, 2008, Pathogenesis of COPD. Part II. Oxidative-antioxidative imbalance [State of the Art Series. Chronic obstructive pulmonary disease in high-and low-income countries. Edited by G. Marks and M. Chan-Yeung. Number 3 in the series], Int. J. Tuberculosis Lung Dis., 12, 368
Duong, 2010, Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice, Am. J. Physiol. Lung Cell. Mol. Physiol., 299, L425, 10.1152/ajplung.00038.2010
Vlahos, 2013, Glutathione peroxidase-1 as a novel therapeutic target for COPD, Redox Rep., 18, 142, 10.1179/1351000213Y.0000000053
Avissar, 1996, Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells, Am. J. Physiol. Lung Cell. Mol. Physiol., 270, L173, 10.1152/ajplung.1996.270.2.L173
Nowak, 1996, Increased content of hydrogen peroxide in the expired breath of cigarette smokers, Eur. Respir. J., 9, 652, 10.1183/09031936.96.09040652
Dekhuijzen, 1996, Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 154, 813, 10.1164/ajrccm.154.3.8810624
Lee, 2009, Oxidative stress in COPD and its measurement through exhaled breath condensate, Clin. Transl. Sci., 2, 150, 10.1111/j.1752-8062.2009.00093.x
Rahman, 2000, Oxidative stress and regulation of glutathione in lung inflammation, Eur. Respir. J., 16, 534, 10.1034/j.1399-3003.2000.016003534.x
Yang, 2009, Air pollutants, oxidative stress and human health, Mutat. Res., 674, 45, 10.1016/j.mrgentox.2008.10.005
Huiart, 2005, Cardiovascular morbidity and mortality in COPD, Chest, 128, 2640, 10.1378/chest.128.4.2640
Mullerova, 2013, Cardiovascular comorbidity in COPD systematic literature review, Chest, 144, 1163, 10.1378/chest.12-2847
Sin, 2005, Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality, Proc. Am. Thorac. Soc., 2, 8, 10.1513/pats.200404-032MS
Chatila, 2008, Comorbidities in chronic obstructive pulmonary disease, Proc. Am. Thorac. Soc., 5, 549, 10.1513/pats.200709-148ET
Berger, 2004, Effect of chronic obstructive pulmonary disease on survival of patients with coronary heart disease having percutaneous coronary intervention, Am. J. Cardiol., 94, 649, 10.1016/j.amjcard.2004.05.034
Anthonisen, 1994, Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study, JAMA, 272, 1497, 10.1001/jama.1994.03520190043033
Hudson, 1973, Arrhythmias associated with acute respiratory failure in patients with chronic airway obstruction, Chest, 63, 661, 10.1378/chest.63.5.661
Gulsvik, 1978, Cardiac arrhythmias in patients with serious pulmonary diseases, Scand. J. Respir. Dis., 59, 154
Mannino, 2008, Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD, Eur. Respir. J., 32, 962, 10.1183/09031936.00012408
Sin, 2006, Mortality in COPD: role of comorbidities, Eur. Respir. J., 28, 1245, 10.1183/09031936.00133805
Maclay, 2009, Vascular dysfunction in chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 180, 513, 10.1164/rccm.200903-0414OC
Dirksen, 2003, Outcome measures in chronic obstructive pulmonary disease (COPD), Thorax, 58, 1007, 10.1136/thorax.58.12.1007
Bäck, 2008, Atherosclerosis, COPD and chronic inflammation, Respir. Med., 4, 60
Domenech, 2018, High risk of subclinical atherosclerosis in COPD exacerbator phenotype, Respir. Med., 141, 165, 10.1016/j.rmed.2018.07.004
Husain, 2015, Inflammation, oxidative stress and renin angiotensin system in atherosclerosis, World J. Biol. Chem., 6, 209, 10.4331/wjbc.v6.i3.209
Banerjee, 2017, Stroke caused by atherosclerosis of the major intracranial arteries, Circ. Res., 120, 502, 10.1161/CIRCRESAHA.116.308441
Maclay, 2011, Increased platelet activation in patients with stable and acute exacerbation of COPD, Thorax, 66, 769, 10.1136/thx.2010.157529
Wedzicha, 2000, Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels, Thromb. Haemost., 84, 210, 10.1055/s-0037-1613998
Lahousse, 2013, Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study, Am. J. Respir. Crit. Care Med., 187, 58, 10.1164/rccm.201206-1046OC
Suwa, 2002, Particulate air pollution induces progression of atherosclerosis, J. Am. Coll. Cardiol., 39, 935, 10.1016/S0735-1097(02)01715-1
Ridker, 2011, Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS), Am. Heart J., 162, 597, 10.1016/j.ahj.2011.06.012
Faraci, 2011, Protecting against vascular disease in brain, Am. J. Physiol. Heart Circ. Physiol., 300, H1566, 10.1152/ajpheart.01310.2010
Basuroy, 2009, Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells, Am. J. Physiol. Cell Physiol., 296, C422, 10.1152/ajpcell.00381.2008
Taraseviciene-Stewart, 2006, Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?, Proc. Am. Thorac. Soc., 3, 687, 10.1513/pats.200605-105SF
Chaouat, 2005, Severe pulmonary hypertension and chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 172, 189, 10.1164/rccm.200401-006OC
Lam, 2009, Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study, J. Am. Coll. Cardiol., 53, 1119, 10.1016/j.jacc.2008.11.051
Ball, 2014, Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α, Am. J. Respir. Crit. Care Med., 189, 314, 10.1164/rccm.201302-0302OC
Weir-McCall, 2015, The role of pulmonary arterial stiffness in COPD, Respir. Med., 109, 1381, 10.1016/j.rmed.2015.06.005
Hilde, 2013, Haemodynamic responses to exercise in patients with COPD, Eur. Respir. J., 41, 1031, 10.1183/09031936.00085612
Skelly, 2006, Risk factors for restenosis after carotid artery angioplasty and stenting, J. Vasc. Surg., 44, 1010, 10.1016/j.jvs.2006.07.039
Bursi, 2010, Chronic obstructive pulmonary disease after myocardial infarction in the community, Am. Heart J., 160, 95, 10.1016/j.ahj.2010.05.004
Santos, 2002, Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD, Eur. Respir. J., 19, 632, 10.1183/09031936.02.00245902
Wright, 1992, Analysis of the structure of the muscular pulmonary arteries in patients with pulmonary hypertension and COPD: National Institutes of Health nocturnal oxygen therapy trial, Lung, 170, 109, 10.1007/BF00175982
Wilkinson, 1988, A pathophysiological study of 10 cases of hypoxic cor pulmonale, Q. J. Med., 66, 65
Friedman, 1976, Lung function and risk of myocardial infarction and sudden cardiac death, N. Engl. J. Med., 294, 1071, 10.1056/NEJM197605132942001
Cook, 1988, Breathlessness, lung function and the risk of heart attack, Eur. Heart J., 9, 1215, 10.1093/oxfordjournals.eurheartj.a062432
Lange, 1991, Ventilatory function impairment and risk of cardiovascular death and of fatal or non-fatal myocardial infarction, Eur. Respir. J., 4, 1080, 10.1183/09031936.93.04091080
Zhang, 2018, Influence of lung function and sleep-disordered breathing on stroke: a community-based study, Eur. J. Neurol., 25, 1307, 10.1111/ene.13722
Truelsen, 2001, Lung function and risk of fatal and non-fatal stroke. The Copenhagen City Heart Study, Int. J. Epidemiol., 30, 145, 10.1093/ije/30.1.145
Liao, 1999, Lower pulmonary function and cerebral subclinical abnormalities detected by MRI: the Atherosclerosis Risk in Communities study, Chest, 116, 150, 10.1378/chest.116.1.150
Bhatt, 2013, Chronic obstructive pulmonary disease and cardiovascular disease, Transl. Res., 162, 237, 10.1016/j.trsl.2013.05.001
Sin, 2005, Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality, Proc. Am. Thorac. Soc., 2, 8, 10.1513/pats.200404-032MS
Abe, 2017, The roles of hypoxia signaling in the pathogenesis of cardiovascular diseases, J. Atheroscler. Thromb., 24, 884, 10.5551/jat.RV17009
Semenza, 2014, Hypoxia-inducible factor 1 and cardiovascular disease, Annu. Rev. Physiol., 76, 39, 10.1146/annurev-physiol-021113-170322
Kato, 2000, Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea, Circulation, 102, 2607, 10.1161/01.CIR.102.21.2607
Heiss, 2014, Regulation of eNOS enzyme activity by posttranslational modification, Curr. Pharm. Des., 20, 3503, 10.2174/13816128113196660745
Arunachalam, 2010, SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol, Biochem. Biophys. Res. Commun., 393, 66, 10.1016/j.bbrc.2010.01.080
Rauchhaus, 2000, Plasma cytokine parameters and mortality in patients with chronic heart failure, Circulation, 102, 3060, 10.1161/01.CIR.102.25.3060
Ueland, 2015, Inflammatory cytokines as biomarkers in heart failure, Clin. Chim. Acta, 443, 71, 10.1016/j.cca.2014.09.001
Harten, 2010, Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection, Antioxid. Redox Signal., 12, 459, 10.1089/ars.2009.2870
Ong, 2014, HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore, Cardiovasc. Res., 104, 24, 10.1093/cvr/cvu172
Jain, 2018, Hypoxia inducible factor as a therapeutic target for atherosclerosis, Pharmacol. Ther., 183, 22, 10.1016/j.pharmthera.2017.09.003
Sidney, 2005, COPD and incident cardiovascular disease hospitalizations and mortality: Kaiser Permanente Medical Care Program, Chest, 128, 2068, 10.1378/chest.128.4.2068
Piepoli, 2016, 2016 European Guidelines on cardiovascular disease prevention in clinical practice The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR), Eur. Heart J., 252, 207
Gudmundsson, 2016, Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik study, Atherosclerosis, 252, 122, 10.1016/j.atherosclerosis.2016.07.919
Badimon, 2012, Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease, Eur. Heart J. Acute Cardiovasc. Care, 1, 60, 10.1177/2048872612441582
Smith, 2014, Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS), Thorax, 69, 987, 10.1136/thoraxjnl-2014-205160
Hill, 2001, Invited review: arteriolar smooth muscle mechanotransduction: Ca(2+) signaling pathways underlying myogenic reactivity, J. Appl. Physiol. (1985), 91, 973, 10.1152/jappl.2001.91.2.973
Ismaeel, 2018, Oxidative stress and arterial dysfunction in peripheral artery disease, Antioxidants (Basel), 7, 145, 10.3390/antiox7100145
Li, 2018, Nicotine induces endothelial dysfunction and promotes atherosclerosis via GTPCH1, J. Cell. Mol. Med., 22, 5406, 10.1111/jcmm.13812
Engin, 2017, Endothelial dysfunction in obesity, Adv. Exp. Med. Biol., 960, 345, 10.1007/978-3-319-48382-5_15
Harrison, 2011, Mitochondrial oxidative stress significantly influences atherogenic risk and cytokine-induced oxidant production, Environ. Health Perspect., 119, 676, 10.1289/ehp.1002857
Shenouda, 2011, Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus, Circulation, 124, 444, 10.1161/CIRCULATIONAHA.110.014506
Siasos, 2009, The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance, Am. J. Hypertens., 22, 586, 10.1038/ajh.2009.57
Taddei, 2001, Age-related reduction of NO availability and oxidative stress in humans, Hypertension, 38, 274, 10.1161/01.HYP.38.2.274
Zhang, 2006, Adverse effects of cigarette smoke on NO bioavailability: role of arginine metabolism and oxidative stress, Hypertension, 48, 278, 10.1161/01.HYP.0000231509.27406.42
Polverino, 2018, COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series), Pulm. Circ., 8, 2045894018758528, 10.1177/2045894018758528
Jennings, 2009, Role of platelets in atherothrombosis, Am. J. Cardiol., 103, 4A, 10.1016/j.amjcard.2008.11.017
Davie, 1991, The coagulation cascade: initiation, maintenance, and regulation, Biochemistry, 30, 10363, 10.1021/bi00107a001
Biljak, 2011, Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease, Platelets, 22, 466, 10.3109/09537104.2011.573887
Viles-Gonzalez, 2004, Atherothrombosis: a widespread disease with unpredictable and life-threatening consequences, Eur. Heart J., 25, 1197, 10.1016/j.ehj.2004.03.011
Koenig, 2007, Biomarkers of atherosclerotic plaque instability and rupture, Arterioscler. Thromb. Vasc. Biol., 27, 15, 10.1161/01.ATV.0000251503.35795.4f
Fluri, 2017, Platelets and stroke, Platelets, Haemostasis and Inflammation, 253, 10.1007/978-3-319-66224-4_16
Cha, 2004, Increased platelet CD63 and P-selectin expression persist in atherosclerotic ischemic stroke, Platelets, 15, 3, 10.1080/09537100310001644024
Davi, 2007, Mechanisms of disease: platelet activation and atherothrombosis, N. Engl. J. Med., 357, 2482, 10.1056/NEJMra071014
Milovanovic, 2004, Relationships between platelets and inflammatory markers in rheumatoid arthritis, Clin. Chim. Acta, 343, 237, 10.1016/j.cccn.2003.12.030
Cui, 2012, Clinical value of mean platelet volume for impaired cardiopulmonary function in very old male patients with chronic obstructive pulmonary disease, Arch. Gerontol. Geriatr., 54, E109, 10.1016/j.archger.2011.09.013
Agapakis, 2016, The role of mean platelet volume in chronic obstructive pulmonary disease exacerbation, Respir. Care, 61, 44, 10.4187/respcare.04132
Steiropoulos, 2013, Mean platelet volume and platelet distribution width in patients with chronic obstructive pulmonary disease: the role of comorbidities, Angiology, 64, 535, 10.1177/0003319712461436
Malerba, 2013, Platelet activation as a novel mechanism of atherothrombotic risk in chronic obstructive pulmonary disease, Expert Rev. Hematol., 6, 475, 10.1586/17474086.2013.814835
Ishida, 2014, Antiplatelet strategies for secondary prevention of stroke and TIA, Curr. Atheroscler. Rep., 16, 449, 10.1007/s11883-014-0449-6
Harrison, 2014, Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy?, Thorax, 69, 609, 10.1136/thoraxjnl-2013-203996
De Silva, 2011, Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke, PLoS ONE, 6, e28393, 10.1371/journal.pone.0028393
Famakin, 2014, The immune response to acute focal cerebral ischemia and associated post-stroke immunodepression: a focused review, Aging Dis., 5, 307
Oppenheim, 2007, Alarmins initiate host defense, Immune-Mediated Diseases, 185, 10.1007/978-0-387-72005-0_19
Matzinger, 1998, An innate sense of danger, Semin Immunol., 399
Vogelgesang, 2010, Functional status of peripheral blood T-cells in ischemic stroke patients, PLoS ONE, 5, e8718, 10.1371/journal.pone.0008718
Lakhan, 2009, Inflammatory mechanisms in ischemic stroke: therapeutic approaches, J. Transl. Med., 7, 97, 10.1186/1479-5876-7-97
Lambertsen, 2012, Inflammatory cytokines in experimental and human stroke, J. Cereb. Blood Flow Metab., 32, 1677, 10.1038/jcbfm.2012.88
Waje-Andreassen, 2005, IL-6: an early marker for outcome in acute ischemic stroke, Acta Neurol. Scand., 111, 360, 10.1111/j.1600-0404.2005.00416.x
Yamasaki, 1995, Interleukin-1 as a pathogenetic mediator of ischemic brain-damage in rats, Stroke, 26, 676, 10.1161/01.STR.26.4.676
Smith, 2004, Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome, BMC Neurol., 4, 2, 10.1186/1471-2377-4-2
Nawashiro, 1997, TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice, J. Cereb. Blood Flow Metab., 17, 483, 10.1097/00004647-199705000-00001
Ginis, 2002, TNF-α–induced tolerance to ischemic injury involves differential control of NF-κB transactivation: the role of NF-κB association with p300 adaptor, J. Cereb. Blood Flow Metab., 22, 142, 10.1097/00004647-200202000-00002
Pettigrew, 2008, Focal cerebral ischemia in the TNFalpha-transgenic rat, J. Neuroinflammation, 5, 47, 10.1186/1742-2094-5-47
Garcia-Bonilla, 2012, Peroxiredoxin sets the brain on fire after stroke, Nat. Med., 18, 858, 10.1038/nm.2797
Daga, 2003, Effects of exogenous vitamin E supplementation on the levels of oxidants and antioxidants in chronic obstructive pulmonary disease, J. Biosci., 28, 7, 10.1007/BF02970125
Bernardo, 2018, Targeting NADPH oxidase-2 reduces cigarette smoke-induced lung inflammation and skeletal muscle wasting in mice, Eur. Respir. Soc., 52, OA195, 10.1183/13993003.congress-2018.OA1945