Những góc nhìn mới về sự kết dính của tế bào: RGD và Integrins

American Association for the Advancement of Science (AAAS) - Tập 238 Số 4826 - Trang 491-497 - 1987
Erkki Ruoslahti1, Michael D. Pierschbacher1
1Cancer Research Center, La Jolla Cancer Research Foundation, La Jolla, CA 92037.

Tóm tắt

Những tiến bộ nhanh chóng đã đạt được trong việc hiểu các tương tác phân tử dẫn đến sự kết dính của tế bào. Nhiều loại protein kết dính có mặt trong các ma trận ngoài tế bào và trong máu chứa chuỗi ba amino acid arginine-glycine-aspartic acid (RGD) là vị trí nhận diện tế bào của chúng. Các protein này bao gồm fibronectin, vitronectin, osteopontin, collagen, thrombospondin, fibrinogen và yếu tố von Willebrand. Các chuỗi RGD của từng protein kết dính được nhận diện bởi ít nhất một thành viên trong một họ các thụ thể có cấu trúc tương đồng, được gọi là integrins, là các protein dị thể có hai tiểu đơn vị xuyên màng. Một số thụ thể này chỉ liên kết với chuỗi RGD của một loại protein kết dính duy nhất, trong khi những thụ thể khác nhận diện nhóm của chúng. Dạng cấu trúc của chuỗi RGD trong các protein riêng lẻ có thể rất quan trọng đối với tính đặc thù của nhận diện này. Phía mặt trong bào tương của màng tế bào, các thụ thể kết nối ma trận ngoài tế bào với khung xương tế bào. Hơn mười protein đã được xác nhận hoặc nghi ngờ có chứa RGD thúc đẩy kết dính đã được phát hiện, và gia đình thụ thể integrin bao gồm ít nhất cũng nhiều thụ thể nhận diện các protein này. Cùng nhau, các protein kết dính và các thụ thể của chúng tạo nên một hệ thống nhận diện linh hoạt, cung cấp cho các tế bào sự bám víu, lực kéo cho sự di chuyển, và các tín hiệu cho sự định hướng, vị trí, phân biệt, và có thể cả sự tăng trưởng.

Từ khóa

#RGD #Integrins #protein kết dính #ma trận ngoài tế bào #phân tử nhận diện #thụ thể #tế bào #arginine-glycine-aspartic acid #fibronectin #vitronectin #osteopontin #collagen #thrombospondin #fibrinogen #yếu tố von Willebrand

Tài liệu tham khảo

AKIYAMA, S.K., SYNTHETIC PEPTIDES COMPETITIVELY INHIBIT BOTH DIRECT BINDING TO FIBROBLASTS AND FUNCTIONAL BIOLOGICAL ASSAYS FOR THE PURIFIED CELL-BINDING DOMAIN OF FIBRONECTIN, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 10402 (1985).

AKIYAMA, S.K., THE INTERACTION OF FIBRONECTIN FRAGMENTS WITH FIBROBLASTIC CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 3256 (1985).

AKIYAMA, S.K., CHARACTERIZATION OF A 140-KD AVIAN CELL-SURFACE ANTIGEN AS A FIBRONECTIN-BINDING MOLECULE, JOURNAL OF CELL BIOLOGY 102: 442 (1986).

ALI, I.U., EFFECTS OF LETS GLYCOPROTEIN ON CELL MOTILITY, CELL 14: 439 (1978).

ARFORS, K.E., A MONOCLONAL-ANTIBODY TO THE MEMBRANE GLYCOPROTEIN COMPLEX CD18 INHIBITS POLYMORPHONUCLEAR LEUKOCYTE ACCUMULATION AND PLASMA LEAKAGE INVIVO, BLOOD 69: 338 (1987).

ARGRAVES, W.S., CDNA SEQUENCES FROM THE ALPHA-SUBUNIT OF THE FIBRONECTIN RECEPTOR PREDICT A TRANSMEMBRANE DOMAIN AND A SHORT CYTOPLASMIC PEPTIDE, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 12922 (1986).

ARGRAVES, W.S., AMINO-ACID-SEQUENCE OF THE HUMAN FIBRONECTIN RECEPTOR, JOURNAL OF CELL BIOLOGY 105: 1183 (1987).

BASARA, M.L., STIMULATION OF HAPTOTAXIS AND MIGRATION OF TUMOR-CELLS BY SERUM SPREADING FACTOR, CANCER RESEARCH 45: 2487 (1985).

BRASS, L.F., IDENTIFICATION AND FUNCTION OF THE HIGH-AFFINITY BINDING-SITES FOR CA-2+ ON THE SURFACE OF PLATELETS, JOURNAL OF CLINICAL INVESTIGATION 73: 626 (1984).

10.1126/science.4012302

BUCK, C.A., INTEGRIN (THE CSAT ANTIGEN) - FUNCTIONALITY REQUIRES OLIGOMERIC INTEGRITY, JOURNAL OF CELL BIOLOGY 103: 2421 (1986).

BURRIDGE, K, CANCER REV 4: 18 (1986).

CARDARELLI, P.M., LYMPHOCYTE-T DIFFERENTIATION AND THE EXTRACELLULAR-MATRIX - IDENTIFICATION OF A THYMOCYTE SUBSET THAT ATTACHES SPECIFICALLY TO FIBRONECTIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 2647 (1986).

CARTER, S.B., PRINCIPLES OF CELL MOTILITY - DIRECTION OF CELL MOVEMENT AND CANCER INVASION, NATURE 208: 1183 (1965).

CHERESH, D.A., DISIALOGANGLIOSIDES-GD2 AND GD3 ARE INVOLVED IN THE ATTACHMENT OF HUMAN-MELANOMA AND NEUROBLASTOMA-CELLS TO EXTRACELLULAR-MATRIX PROTEINS, JOURNAL OF CELL BIOLOGY 102: 688 (1986).

DAMSKY, C.H., MANIPULATION OF CELL-CELL AND CELL-SUBSTRATUM INTERACTIONS IN MOUSE MAMMARY-TUMOR EPITHELIAL-CELLS USING BROAD-SPECTRUM ANTISERA, JOURNAL OF CELL BIOLOGY 89: 173 (1981).

10.1126/science.3576223

DEDHAR, S, A CELL-SURFACE RECEPTOR COMPLEX FOR COLLAGEN TYPE-I RECOGNIZES THE ARG-GLY-ASP SEQUENCE, JOURNAL OF CELL BIOLOGY 104: 585 (1987).

10.1126/science.6823544

FITZGERALD, L.A., PROTEIN-SEQUENCE OF ENDOTHELIAL GLYCOPROTEIN-IIIA DERIVED FROM A CDNA CLONE - IDENTITY WITH PLATELET GLYCOPROTEIN IIIA AND SIMILARITY TO INTEGRIN, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 3936 (1987).

GARTNER, T.K., THE TETRAPEPTIDE ANALOG OF THE CELL ATTACHMENT SITE OF FIBRONECTIN INHIBITS PLATELET-AGGREGATION AND FIBRINOGEN BINDING TO ACTIVATED PLATELETS, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 11891 (1985).

GEHLSEN K.R. unpublished data.

GIGUERE, L, FACTORS INVOLVED IN THE CONTROL OF PROLIFERATION OF BOVINE CORNEAL ENDOTHELIAL-CELLS MAINTAINED IN SERUM-FREE MEDIUM, JOURNAL OF CELLULAR PHYSIOLOGY 110: 72 (1982).

GINSBERG, M, INHIBITION OF FIBRONECTIN BINDING TO PLATELETS BY PROTEOLYTIC FRAGMENTS AND SYNTHETIC PEPTIDES WHICH SUPPORT FIBROBLAST ADHESION, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 3931 (1985).

GINSBERG, M.H., IMMUNOCHEMICAL AND AMINO-TERMINAL SEQUENCE COMPARISON OF 2 CYTOADHESINS INDICATES THEY CONTAIN SIMILAR OR IDENTICAL BETA-SUBUNITS AND DISTINCT ALPHA-SUBUNITS, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 5437 (1987).

GREVE, J.M., MONOCLONAL-ANTIBODIES WHICH ALTER THE MORPHOLOGY OF CULTURED CHICK MYOGENIC CELLS, JOURNAL OF CELLULAR BIOCHEMISTRY 18: 221 (1982).

GROBSTEIN, C, EXTRACELLULAR MATRIX: 9 (1975).

HALL, D.E., EMBRYONIC NEURAL RETINAL CELL RESPONSE TO EXTRACELLULAR-MATRIX PROTEINS - DEVELOPMENTAL-CHANGES AND EFFECTS OF THE CELL SUBSTRATUM ATTACHMENT ANTIBODY (CSAT), JOURNAL OF CELL BIOLOGY 104: 623 (1987).

HASEGAWA, T, CHARACTERIZATION OF A MEMBRANE-ASSOCIATED GLYCOPROTEIN COMPLEX IMPLICATED IN CELL-ADHESION TO FIBRONECTIN, JOURNAL OF CELLULAR BIOCHEMISTRY 28: 307 (1985).

HAVERSTICK, D.M., INHIBITION OF PLATELET-ADHESION TO FIBRONECTIN, FIBRINOGEN, AND VONWILLEBRAND-FACTOR SUBSTRATES BY A SYNTHETIC TETRAPEPTIDE DERIVED FROM THE CELL-BINDING DOMAIN OF FIBRONECTIN, BLOOD 66: 946 (1985).

HAY E.D. CELL BIOL EXTRACELLU (1985).

HAYMAN, E.G., CODISTRIBUTION OF HEPARAN-SULFATE PROTEOGLYCAN, LAMININ, AND FIBRONECTIN IN THE EXTRACELLULAR-MATRIX OF NORMAL RAT-KIDNEY CELLS AND THEIR COORDINATE ABSENCE IN TRANSFORMED-CELLS, JOURNAL OF CELL BIOLOGY 94: 28 (1982).

HAYMAN, E.G., DETACHMENT OF CELLS FROM CULTURE SUBSTRATE BY SOLUBLE FIBRONECTIN PEPTIDES, JOURNAL OF CELL BIOLOGY 100: 1948 (1985).

HEDMAN, K, STRUCTURE OF THE PERICELLULAR MATRIX - ASSOCIATION OF HEPARAN AND CHONDROITIN SULFATES WITH FIBRONECTIN-PROCOLLAGEN FIBERS, CELL 28: 663 (1982).

HIRST, R, PHOSPHORYLATION OF THE FIBRONECTIN RECEPTOR COMPLEX IN CELLS TRANSFORMED BY ONCOGENES THAT ENCODE TYROSINE KINASES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 6470 (1986).

HORWITZ, A, THE CELL SUBSTRATE ATTACHMENT (CSAT) ANTIGEN HAS PROPERTIES OF A RECEPTOR FOR LAMININ AND FIBRONECTIN, JOURNAL OF CELL BIOLOGY 101: 2134 (1985).

10.1038/320531a0

HUMPHRIES, M.J., IDENTIFICATION OF AN ALTERNATIVELY SPLICED SITE IN HUMAN-PLASMA FIBRONECTIN THAT MEDIATES CELL TYPE-SPECIFIC ADHESION, JOURNAL OF CELL BIOLOGY 103: 2637 (1986).

10.1126/science.3726541

HYNES, R.O., INTEGRINS - A FAMILY OF CELL-SURFACE RECEPTORS, CELL 48: 549 (1987).

HYNES, R, CYTOSKELETAL ELEMENT: 100 (1981).

KISHIMOTO, T.K., CLONING OF THE BETA-SUBUNIT OF THE LEUKOCYTE ADHESION PROTEINS - HOMOLOGY TO AN EXTRACELLULAR-MATRIX RECEPTOR DEFINES A NOVEL SUPERGENE FAMILY, CELL 48: 681 (1987).

KLEINMAN, H.K., GANGLIOSIDE INHIBITION OF FIBRONECTIN-MEDIATED CELL-ADHESION TO COLLAGEN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 3367 (1979).

KLOCZEWIAK, M, PLATELET RECEPTOR RECOGNITION SITE ON HUMAN-FIBRINOGEN - SYNTHESIS AND STRUCTURE-FUNCTION RELATIONSHIP OF PEPTIDES CORRESPONDING TO THE CARBOXY-TERMINAL SEGMENT OF THE GAMMA-CHAIN, BIOCHEMISTRY 23: 1767 (1984).

KLOCZEWIAK, M, RECOGNITION SITE FOR THE PLATELET RECEPTOR IS PRESENT ON THE 15-RESIDUE CARBOXY-TERMINAL FRAGMENT OF THE GAMMA-CHAIN OF HUMAN-FIBRINOGEN AND IS NOT INVOLVED IN THE FIBRIN POLYMERIZATION REACTION, THROMBOSIS RESEARCH 29: 249 (1983).

LAM, SCT, EVIDENCE THAT ARGINYL-GLYCYL-ASPARTATE PEPTIDES AND FIBRINOGEN GAMMA-CHAIN PEPTIDES SHARE A COMMON BINDING-SITE ON PLATELETS, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 947 (1987).

LAWLER, J, THE STRUCTURE OF HUMAN THROMBOSPONDIN, AN ADHESIVE GLYCOPROTEIN WITH MULTIPLE CALCIUM-BINDING SITES AND HOMOLOGIES WITH SEVERAL DIFFERENT PROTEINS, JOURNAL OF CELL BIOLOGY 103: 1635 (1986).

LEPTIN, M, DROSOPHILA POSITION-SPECIFIC ANTIGENS RESEMBLE THE VERTEBRATE FIBRONECTIN-RECEPTOR FAMILY, EMBO JOURNAL 6: 1037 (1987).

MACKRELL A COMMUNICATION.

MACPHERSON, I, AGAR SUSPENSION CULTURE FOR SELECTIVE ASSAY OF CELLS TRANSFORMED BY POLYOMA VIRUS, VIROLOGY 23: 291 (1964).

MILLER, L.J., PURIFICATION AND ALPHA-SUBUNIT N-TERMINAL SEQUENCES OF HUMAN MAC-1 AND P150,95 LEUKOCYTE ADHESION PROTEINS, JOURNAL OF IMMUNOLOGY 138: 2381 (1987).

NEFF, N.T., A MONOCLONAL-ANTIBODY DETACHES EMBRYONIC SKELETAL-MUSCLE FROM EXTRACELLULAR MATRICES, JOURNAL OF CELL BIOLOGY 95: 654 (1982).

NOLL, H, CHARACTERIZATION OF TOPOSOMES FROM SEA-URCHIN BLASTULA CELLS - A CELL ORGANELLE MEDIATING CELL-ADHESION AND EXPRESSING POSITIONAL INFORMATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 8062 (1985).

NURDEN, A.T., BIOCH PLATELETS: 111 (1986).

OLDBERG, A, CLONING AND SEQUENCE-ANALYSIS OF RAT BONE SIALOPROTEIN (OSTEOPONTIN) CDNA REVEALS AN ARG-GLY-ASP CELL-BINDING SEQUENCE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 8819 (1986).

10.1126/science.3094145

PARISE, L.V., RECONSTITUTION OF THE PURIFIED PLATELET FIBRINOGEN RECEPTOR - FIBRINOGEN BINDING-PROPERTIES OF THE GLYCOPROTEIN-IIB-IIIA COMPLEX, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 10698 (1985).

PARISE, L.V., FIBRONECTIN-BINDING PROPERTIES OF THE PURIFIED PLATELET GLYCOPROTEIN IIB-IIIA COMPLEX, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 14011 (1986).

PATEL, V.P., THE FIBRONECTIN RECEPTOR ON MAMMALIAN ERYTHROID PRECURSOR CELLS - CHARACTERIZATION AND DEVELOPMENTAL REGULATION, JOURNAL OF CELL BIOLOGY 102: 449 (1986).

PENNYPACKER, J.P., INFLUENCE OF AN ADHESIVE CELL-SURFACE PROTEIN ON CHONDROGENIC EXPRESSION INVITRO, EXPERIMENTAL CELL RESEARCH 121: 411 (1979).

PERKINS, R.M., GANGLIOSIDES AS RECEPTORS FOR FIBRONECTIN - COMPARISON OF CELL SPREADING ON A GANGLIOSIDE-SPECIFIC LIGAND WITH THAT ON FIBRONECTIN, EXPERIMENTAL CELL RESEARCH 141: 231 (1982).

PHILLIPS, D.R., PLATELET MEMBRANE DEFECTS IN GLANZMANNS THROMBASTHENIA - EVIDENCE FOR DECREASED AMOUNTS OF 2 MAJOR GLYCOPROTEINS, JOURNAL OF CLINICAL INVESTIGATION 60: 535 (1977).

PIERSCHBACHER, M.D., THE CELL ATTACHMENT DOMAIN OF FIBRONECTIN - DETERMINATION OF THE PRIMARY STRUCTURE, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 9593 (1982).

PIERSCHBACHER, M.D., CELL ATTACHMENT ACTIVITY OF FIBRONECTIN CAN BE DUPLICATED BY SMALL SYNTHETIC FRAGMENTS OF THE MOLECULE, NATURE 309: 30 (1984).

PIERSCHBACHER, M.D., VARIANTS OF THE CELL RECOGNITION SITE OF FIBRONECTIN THAT RETAIN ATTACHMENT-PROMOTING ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 5985 (1984).

PIERSCHBACHER M.D. unpublished data.

PLOW, E.F., EVIDENCE THAT 3 ADHESIVE PROTEINS INTERACT WITH A COMMON RECOGNITION SITE ON ACTIVATED PLATELETS, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 5388 (1984).

PLOW, E.F., IMMUNOLOGICAL RELATIONSHIP BETWEEN PLATELET MEMBRANE GLYCOPROTEIN GPIIB/IIIA AND CELL-SURFACE MOLECULES EXPRESSED BY A VARIETY OF CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 6002 (1986).

PLOW, E.F., THE EFFECT OF ARG-GLY-ASP-CONTAINING PEPTIDES ON FIBRINOGEN AND VON WILLEBRAND FACTOR BINDING TO PLATELETS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 8057 (1985).

PONCZ, M, STRUCTURE OF THE PLATELET MEMBRANE GLYCOPROTEIN-IIB - HOMOLOGY TO THE ALPHA-SUBUNITS OF THE VITRONECTIN AND FIBRONECTIN MEMBRANE-RECEPTORS, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 8476 (1987).

PYTELA, R, IDENTIFICATION AND ISOLATION OF A 140-KD CELL-SURFACE GLYCOPROTEIN WITH PROPERTIES EXPECTED OF A FIBRONECTIN RECEPTOR, CELL 40: 191 (1985).

PYTELA, R, ARGININE-GLYCINE-ASPARTIC ACID ADHESION RECEPTORS, METHODS IN ENZYMOLOGY 144: 475 (1987).

PYTELA, R, A 125/115-KDA CELL-SURFACE RECEPTOR SPECIFIC FOR VITRONECTIN INTERACTS WITH THE ARGININE-GLYCINE-ASPARTIC ACID ADHESION SEQUENCE DERIVED FROM FIBRONECTIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 5766 (1985).

10.1126/science.2420006

PYTELA R unpublished data.

RUOSLAHTI, E, ARG-GLY-ASP - A VERSATILE CELL RECOGNITION SIGNAL, CELL 44: 517 (1986).

SABA, T.M., PLASMA FIBRONECTIN (OPSONIC GLYCOPROTEIN) - ITS SYNTHESIS BY VASCULAR ENDOTHELIAL-CELLS AND ROLE IN CARDIOPULMONARY INTEGRITY AFTER TRAUMA AS RELATED TO RETICULOENDOTHELIAL FUNCTION, AMERICAN JOURNAL OF MEDICINE 68: 577 (1980).

SANTORO, S.A., COMPETITION FOR RELATED BUT NONIDENTICAL BINDING-SITES ON THE GLYCOPROTEIN-IIB-IIIA COMPLEX BY PEPTIDES DERIVED FROM PLATELET ADHESIVE PROTEINS, CELL 48: 867 (1987).

SPRINGER T COMMUNICATION.

SPRINGER, T.A., THE LYMPHOCYTE FUNCTION-ASSOCIATED LFA-1, CD2, AND LFA-3 MOLECULES - CELL-ADHESION RECEPTORS OF THE IMMUNE-SYSTEM, ANNUAL REVIEW OF IMMUNOLOGY 5: 223 (1987).

STRONG, D.D., LAMPREY FIBRINOGEN GAMMA-CHAIN - CLONING, CDNA SEQUENCING, AND GENERAL CHARACTERIZATION, BIOCHEMISTRY 24: 92 (1985).

Suzuki, S., Journal of Biological Chemistry 262: 14080 (1987).

SUZUKI, S, CDNA AND AMINO-ACID-SEQUENCES OF THE CELL-ADHESION PROTEIN-RECEPTOR RECOGNIZING VITRONECTIN REVEAL A TRANSMEMBRANE DOMAIN AND HOMOLOGIES WITH OTHER ADHESION PROTEIN RECEPTORS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 8614 (1986).

TAKADA, J, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 3239 (1987).

TAKADA, Y, FIBRONECTIN RECEPTOR STRUCTURES IN THE VLA FAMILY OF HETERODIMERS, NATURE 326: 607 (1987).

TAMKUN, J.W., STRUCTURE OF INTEGRIN, A GLYCOPROTEIN INVOLVED IN THE TRANSMEMBRANE LINKAGE BETWEEN FIBRONECTIN AND ACTIN, CELL 46: 271 (1986).

TARONE, G, CELL-SURFACE MOLECULES AND FIBRONECTIN-MEDIATED CELL-ADHESION - EFFECT OF PROTEOLYTIC DIGESTION OF MEMBRANE-PROTEINS, JOURNAL OF CELL BIOLOGY 94: 179 (1982).

THIERY, J.P., CELL-MIGRATION IN THE VERTEBRATE EMBRYO - ROLE OF CELL-ADHESION AND TISSUE ENVIRONMENT IN PATTERN-FORMATION, ANNUAL REVIEW OF CELL BIOLOGY 1: 91 (1985).

THOMAS, D.D., FIBRONECTIN TETRAPEPTIDE IS TARGET FOR SYPHILIS SPIROCHETE CYTADHERENCE, JOURNAL OF EXPERIMENTAL MEDICINE 162: 1715 (1985).

WRIGHT, S.D., C3BI RECEPTOR (COMPLEMENT RECEPTOR TYPE-3) RECOGNIZES A REGION OF COMPLEMENT PROTEIN-C3 CONTAINING THE SEQUENCE ARG-GLY-ASP, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 1965 (1987).

YAMADA, K.M., DUALISTIC NATURE OF ADHESIVE PROTEIN FUNCTION - FIBRONECTIN AND ITS BIOLOGICALLY-ACTIVE PEPTIDE-FRAGMENTS CAN AUTOINHIBIT FIBRONECTIN FUNCTION, JOURNAL OF CELL BIOLOGY 99: 29 (1984).