Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

American Association for the Advancement of Science (AAAS) - Tập 3 Số 73 - 2011
Roberto Lande1,2, Dipyaman Ganguly1,3, Valeria Facchinetti1, Loredana Frasca2, Curdin Conrad1, Josh Gregorio1,3, Stephan Meller1, Georgios Chamilos2, Rosalie Sebasigari1, Valeria Riccieri4, Roland L. Bassett5, Hideki Amuro6, Shirou Fukuhara6, Tomoki� Ito6, Yong-Jun Liu1, Michel Gilliet7,1,8,3
1Department of Immunology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
2Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanitá, 00161 Rome, Italy.
3Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA
4Division of Rheumatology, Department of Clinical Medicine and Therapy, University La Sapienza of Rome, 00161 Rome, Italy.
5Department of Biostatistics, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
6First Department of Internal Medicine, Kansai Medical University, Osaka 579-8506, Japan.
7Department of Dermatology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
8Department of Melanoma Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Tóm tắt

In systemic lupus erythematosus, neutrophils release peptide/self-DNA complexes that trigger plasmacytoid dendritic cell activation and autoantibody formation.

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Tài liệu tham khảo

10.1177/0961203308090020

10.1146/annurev.immunol.23.021704.115843

10.1038/nri1957

10.1016/j.coi.2009.08.005

10.1126/science.1064890

10.1093/intimm/14.4.411

10.4049/jimmunol.176.4.2074

10.4049/jimmunol.181.9.5875

10.1136/ard.58.5.309

McConnell J. R., Crockard A. D., Cairns A. P., Bell A. L., Neutrophils from systemic lupus erythematosus patients demonstrate increased nuclear DNA damage. Clin. Exp. Rheumatol. 20, 653–660 (2002).

10.1002/art.1780251204

10.1136/ard.49.1.46

10.1016/0090-1229(88)90014-1

10.1002/art.1780260509

10.1006/clin.1994.1087

10.1084/jem.20021553

10.1084/jem.20050338

10.1084/jem.20050914

10.1172/JCI23025

10.1002/art.20254

10.4049/jimmunol.171.6.3296

10.1038/415389a

10.1189/jlb.0403147

10.1038/nature06116

10.1126/science.1092385

10.1083/jcb.200606027

10.1038/nrmicro1710

10.1038/nrmicro976

10.1183/09031936.00080806

10.1038/416603a

10.1007/s00296-006-0173-9

10.1023/A:1023286831246

10.1182/blood-2008-07-171629

10.1016/j.niox.2010.01.001

10.1182/blood.V97.12.3951

10.1038/nm.1959

10.1081/NCN-100002544

10.1007/s10067-007-0768-x

10.1182/blood-2009-05-221606

10.1186/1471-2172-9-34

10.1073/pnas.0909927107

10.1038/nature09102

10.1046/j.1365-2249.2000.01228.x

10.1189/jlb.1102567

10.1182/blood.V96.8.2822

10.1038/ng.81

10.1056/NEJMoa0707865

10.1016/S1074-7613(00)80278-2

10.1084/jem.20090480

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American Association for the Advancement of Science (AAAS)

Tập 3 Số 73

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