Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group study

Alzheimer's & Dementia - Tập 14 - Trang 271-279 - 2018
Isaac Acosta1, Guilherme Borges2, Rebeca Aguirre-Hernandez3, Ana Luisa Sosa1, Martin Prince4
1Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
2Departament of Epidemiologic and Psychosocial Research, National Institute of Psychiatry Ramon de la Fuente Muniz, Mexico City, Mexico
3Department of Pharmacology, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
4Department of Health Service and Population Research, King's College London (Institute of Psychiatry), London, UK

Tóm tắt

AbstractIntroduction

Cognitive and/or memory impairment are the main clinical markers currently used to identify subjects at risk of developing dementia. This study aimed to explore the relationship between the presence of neuropsychiatric symptoms and dementia incidence.

Methods

We analyzed the association between neuropsychiatric symptoms and incident dementia in a cohort of 1355 Mexican older adults from the general population over 3 years of follow‐up, modeling cumulative incidence ratios using Poisson models.

Results

Five neuropsychiatric symptoms were associated with incident dementia: delusions, hallucinations, anxiety, aberrant motor behavior, and depression. The simultaneous presence of two symptoms had a relative risk, adjusted for mild cognitive impairment, diabetes, indicators of cognitive function, and sociodemographic factors, of 1.9 (95% confidence interval, 1.2–2.9), whereas the presence of three to five, similarly adjusted, had a relative risk of 3.0 (95% confidence interval, 1.9–4.8).

Discussion

Neuropsychiatric symptoms are common in predementia states and may independently contribute as risk factors for developing dementia.


Tài liệu tham khảo

ADI, 2015, World Alzheimer Report 2015: The Global Impact of Dementia An Analysis of Prevalence, Incidence, Cost and Trends WHO, 2012, Dementia: A Public Health Priority, 112 Gainotti G, 2010, Origins, controversies and recent developments of the MCI construct, Curr Alzheimer Res, 7, 271, 10.2174/156720510791050858 10.3233/JAD-130881 10.1212/WNL.0b013e31828728ac 10.3233/JAD-2010-1255 10.1016/j.jalz.2015.05.017 10.1159/000112509 10.1016/j.jalz.2011.05.2410 10.1097/JGP.0b013e3181e0450d 10.1080/09540260802095099 10.1017/S1355617710001621 10.1017/S1092852900016175 10.1212/WNL.0b013e3181e8e8b8 Lopez‐Pousa S, 2007, Caracterización y prevalencia de los síntomas psicológicos y conductuales en la demencia, Revista de neurologia, 45, 683, 10.33588/rn.4511.2007535 10.1002/gps.3873 10.1016/j.jdiacomp.2016.06.005 10.3233/JAD-2012-120169 Prina AM, 2016, Cohort Profile: The 10/66 study, Int J Epidemiol, 46, 406 10.1016/S0140-6736(12)60399-7 10.1186/1471-2458-7-165 10.1016/S0140-6736(03)12772-9 10.1186/1471-2458-8-219 10.1176/jnp.12.2.233 10.1371/journal.pmed.1001170 ADA, 2013, Diagnosis and classification of diabetes mellitus, Diabetes Care, 36, S67, 10.2337/dc13-S067 10.1002/mpr.299 10.1177/1536867X0900900201 10.1093/aje/kwh090 10.1017/CBO9780511575884 Preston DL, 2005, Poisson Regression in Epidemiology, 10.1002/0470011815.b2a03094 10.2307/2685060 StataCorp, 2013, Stata Statistical Software: Release 13 10.1093/ageing/afq151 10.1016/j.jalz.2012.12.001 10.4088/JCP.08m04181 10.1159/000107100 10.2147/NDT.S47133 10.1016/j.arcmed.2012.10.014 10.1017/S1041610209991189 10.1016/j.biopsych.2009.02.013 10.1016/j.jagp.2013.01.006 10.1097/00002093-200401000-00004 10.1002/gps.1760 10.1159/000338410 10.1017/S1041610210000281 10.1002/gps.2187 10.3233/JAD-150692 10.1177/0898264311421199 10.1016/j.jalz.2015.12.007 10.1016/S0140-6736(08)61002-8 10.1371/journal.pone.0136181 Gutiérrez J, 2012, Encuesta Nacional de Salud y Nutrición 2012. Resultados Nacionales 10.1002/gps.3868 10.1017/S104161020700484X Ávila‐Funes JA, 2007, Síntomas depresivos como factor de riesgo de dependencia en adultos mayores, Salud Publica Mex, 49, 367 10.1080/09540260802094613 10.1038/nrneurol.2011.2 10.1016/j.arcmed.2012.11.003
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Alzheimer's & Dementia

Tập 14

271-279

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