Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group study

Alzheimer's & Dementia - Tập 14 - Trang 271-279 - 2018
Isaac Acosta1, Guilherme Borges2, Rebeca Aguirre-Hernandez3, Ana Luisa Sosa1, Martin Prince4
1Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico
2Departament of Epidemiologic and Psychosocial Research, National Institute of Psychiatry Ramon de la Fuente Muniz, Mexico City, Mexico
3Department of Pharmacology, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
4Department of Health Service and Population Research, King's College London (Institute of Psychiatry), London, UK

Tóm tắt

AbstractIntroductionCognitive and/or memory impairment are the main clinical markers currently used to identify subjects at risk of developing dementia. This study aimed to explore the relationship between the presence of neuropsychiatric symptoms and dementia incidence.MethodsWe analyzed the association between neuropsychiatric symptoms and incident dementia in a cohort of 1355 Mexican older adults from the general population over 3 years of follow‐up, modeling cumulative incidence ratios using Poisson models.ResultsFive neuropsychiatric symptoms were associated with incident dementia: delusions, hallucinations, anxiety, aberrant motor behavior, and depression. The simultaneous presence of two symptoms had a relative risk, adjusted for mild cognitive impairment, diabetes, indicators of cognitive function, and sociodemographic factors, of 1.9 (95% confidence interval, 1.2–2.9), whereas the presence of three to five, similarly adjusted, had a relative risk of 3.0 (95% confidence interval, 1.9–4.8).DiscussionNeuropsychiatric symptoms are common in predementia states and may independently contribute as risk factors for developing dementia.

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Alzheimer's & Dementia

Tập 14

271-279

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