Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study

Abel, 1992, Elevated GABA levels attenuates the metabolic responses to bilateral ischemia, J. Neurochem., 58, 740, 10.1111/j.1471-4159.1992.tb09780.x Baldwin, 1994, Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat, Br. J. Pharmacol., 112, 188, 10.1111/j.1476-5381.1994.tb13050.x Buchan, 1994, A selective N-type calcium channel blockers prevent CA1 injury 24 h following severe forebrain ischemia and reduces infarction following focal ischemia, J. Cereb. Blood Flow Metab., 14, 903, 10.1038/jcbfm.1994.121 Choi, 1990, Methods of antagonizing glutamate neurotoxicity, Cerebrovasc. Brain Metab. Rev., 2, 105 Choi, 1990, The role of glutamate neurotoxicity in hypoxicischemic neuronal death, Annu. Rev. Neurosci., 13, 171, 10.1146/annurev.ne.13.030190.001131 Corbett, 1992, Imparied acquisition of the Morris water maze following global ischemia in gerbil, Neuroreport, 3, 204, 10.1097/00001756-199202000-00021 Crain, 1988, Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil: a silver impregnation study, Neuroscience, 27, 387, 10.1016/0306-4522(88)90276-X Dietrich, 1993, Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats, J. Cereb. Blood Flow Metab., 13, 541, 10.1038/jcbfm.1993.71 Donzanti, 1988, An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates, Life Sci., 43, 913, 10.1016/0024-3205(88)90267-6 Gallyas, 1980, A reliable method to localize axonal damage after axotomy, Stain Tech., 55, 291, 10.3109/10520298009067257 Gallyas, 1980, A reliable and sensitive method to localize terminal degeneration and lysosomes in the central nervous system, Stain Tech., 55, 299, 10.3109/10520298009067258 Garcia, 1989, Pathophysiology of cerebral ischemia, CRC Crit. Rev. Neurobiol., 4, 303 Ginsberg, 1992, Therapeutic modulation of brain temperature: Relevance to ischemic brain injury, Cerebrovasc. Brain Metab. Rev., 4, 189 Graham, 1994, Effect of lamotrigine on microdialysis amino acid concentration in the striatum in the striatum after focal ischemia in rats, Br. J. Pharmacol., 112, 278P Graham, 1993, Liming ischemic injury by inhibition of excitatory amino-acid release, J. Cereb. Blood Flow Metab., 13, 88, 10.1038/jcbfm.1993.11 Heron, 1993, Adenosine modulation of amino acid release in rat hippocampus during ischemia and veratridine depolarization, Brain Res., 608, 27, 10.1016/0006-8993(93)90769-J Heron, 1995, Effects of an A1 adenosine receptor agonist on the neurochemical, behavioral and histological consequences of ischemia, Brain Res., 641, 217, 10.1016/0006-8993(94)90149-X Lang, 1993, Lamotrigine, phenytoin and carbamazepine interactions on the sodium present in N4TG1 mouse neuroblastoma cells, J. Pharmacol. Exp. Ther., 266, 829 Leach, 1993, BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage, Stroke, 24, 1063, 10.1161/01.STR.24.7.1063 Lees, 1993, Studies on the mechanism of action of the novel anticonvulsant lamotrigine using primary neuroglial cultures from the rat cortex, Brain Res., 612, 190, 10.1016/0006-8993(93)91660-K Lefieffre, 1993, The pyrimidine-derivative, BW1003C87, protects CAl and striatal neurons following transient severe forebrain ischemia in rats. A microdialysis and histological study, Neuroscience, 56, 93, 10.1016/0306-4522(93)90565-W Lipton, 1994, Excitatory aminoacids as a final common pathway for neurologic disorders, New Engl. J. Med., 330, 613, 10.1056/NEJM199403033300907 Lo, 1993, Profiles of extracellular amino acids changes in focal cerebral ischaemia: Effects of mild hypothermia, Neurol. Res., 15, 281, 10.1080/01616412.1993.11740149 Lustig, 1992, A novel inhibitor of glutamate release reduces excitotoxic injury, Neurosci. Lett., 143, 229, 10.1016/0304-3940(92)90271-8 McGeer, 1983, Lamotrigine protects against kainate but not ibotenate lesions in cell culture, Neurosci. Lett., 112, 348, 10.1016/0304-3940(90)90229-3 Meldrum, 1992, Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87, Brain Res., 593, 1, 10.1016/0006-8993(92)91254-C Mertes, 1994, Brain death and myocardial injury: Role of cardiac sympathetic innervation evaluated by in vivo interstitial microdialysis, 26, 231 Mitani, 1991, Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: Brain microdialysis study, Neuroscience, 42, 661, 10.1016/0306-4522(91)90035-M Morris, 1984, Developments of a water-maze prodrome for studying spatial learning in the rat, J. Neurosci. Methods, 11, 47, 10.1016/0165-0270(84)90007-4 Nakata, 1992, Effects of pretreatment with sublethal ischemia on the extracellular glutamate concentrations during secondary ischemia in the gerbil hippocampus evaluated with intracerebral microdialysis, Neurosci. Lett., 138, 86, 10.1016/0304-3940(92)90478-P Shuaib, 1994, Chlormethiazole protects the brain from transient forebrain ischemic when used up to four hours after the insult, Neurosci. Lett., 197, 1 Shuaib, 1992, γ-Vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient ischemic in gerbils, Brain Res., 590, 13, 10.1016/0006-8993(92)91076-Q Shuaib, 1994, A decreased glutamate release during hypothyroidism may contribute to protection in cerebral ischemic, Exp. Neurol., 128, 260, 10.1006/exnr.1994.1135 Shuaib, 1992, Repetitive transient forebrain ischemic in gerbils: Delayed neuronal damage in the substantia nigra reticulata, Brain Res., 574, 120, 10.1016/0006-8993(92)90807-L Shuaib, 1994, Hypothyroidism protects the brain from the effects of ischemic, Exp. Neurol., 127, 119, 10.1006/exnr.1994.1085 Shuaib, 1993, GABA agonise museimol is neuroprotective in repetitive transient forebrain ischemic in gerbils, Exp. Neurol., 123, 284, 10.1006/exnr.1993.1160 Siesjö, 1992, Pathophysiology and treatment of focal cerebral ischemic. Part I: Pathophysiology, J. Neurosurg., 77, 169, 10.3171/jns.1992.77.2.0169 Simpson, 1992, Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: Effects of adenosine receptor agonists and antagonists, J. Neurochem., 58, 1683, 10.1111/j.1471-4159.1992.tb10041.x Smith, 1995, Cerebroprotective effect of lamotrigine after focal ischemic in gerbils, Stroke, 26, 117, 10.1161/01.STR.26.1.117 Sternau, 1989, Role of GABA in selective vulnerability in gerbils, Stroke, 20, 281, 10.1161/01.STR.20.2.281 Valentino, 1993, A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemic, 90, 7894 Wiard, 1995, Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemic, Stroke, 26, 466, 10.1161/01.STR.26.3.466 Wishart, 1994, Differential effects of amphetamine and haloperidol on recovery after global forebrain ischemic, Pharmacol. Biochem. Behav., 47, 963, 10.1016/0091-3057(94)90304-2