Neuroprotective effect of a new photobiomodulation technique against Aβ25–35 peptide–induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 4 - Trang 54-63 - 2018
Guillaume Blivet1, Johann Meunier2, Francois J. Roman2, Jacques Touchon3,4,5
1REGEnLIFE, Montpellier, France
2Amylgen, Montferrier-sur-Lez, France
3INSERM U1061, Montpellier, France
4Montpellier University, Montpellier, France
5JT Conseils, Montpellier, France

Tóm tắt

AbstractIntroductionPhotobiomodulation was assessed as a novel treatment of Alzheimer's disease (AD) by the use of a new device RGn500 combining photonic and magnetic emissions in a mouse model of AD.MethodsFollowing the injection of amyloid β 25‐35 peptide in male Swiss mice, RGn500 was applied once a day for 7 days either on the top of the head or the center of abdomen or both.ResultsRGn500 daily application for 10 min produced a neuroprotective effect on the neurotoxic effects of amyloid β 25‐35 peptide injection when this type of photobiomodulation was applied both on the head and on the abdomen. Protection was demonstrated by memory restoration and on the normalization of key markers of AD (amyloid β 1‐42, pTau), oxidative stress (lipid peroxidation), apoptosis (Bax/Bcl2) and neuroinflammation.DiscussionRGn500 displays therapeutic efficacy similar to other pharmacological approaches evaluated in this model of AD.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 4

54-63

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