Neuropeptides in Migraine and Cluster Headache

Cephalalgia - Tập 14 Số 5 - Trang 320-327 - 1994
Lars Edvinsson1, Peter J. Goadsby2
1Department of Internal Medicine, University Hospital, Lund, Sweden
2Department of Neurology1, The Prince Henry Hospital, University of New South Wales, Australia

Tóm tắt

The cerebral circulation is invested by a rich network of neuropeptide Y (NPY) and noradrenaline containing sympathetic nerve fibers in arteries, arterioles and veins. However, the nerve supply of vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) containing fibers is sparse. While noradrenaline and NPY cause vasoconstriction, VIP, SP and CGRP are potent vasodilators. Stimulation of the trigeminal ganglion in cat and man elicits release of SP and CGRP. Subjects with spontaneous attacks of migraine show release of CGRP in parallel with headache. Cluster headache patients have release of CGRP and VIP during bouts. Treatment with sumatriptan aborts headache in migraine and cluster headache as well as the concomitant peptide release.

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