Neuropeptides: The Slower Neurotransmitters

Resonance - Tập 25 - Trang 1741-1752 - 2020
Umer Saleem Bhat1, Kavita Babu2
1Department of Biological Sciences, Indian Institute of Science Education and Research IISER, Mohali, Knowledge City, Punjab, India
2Centre for Neuroscience, Indian Institute of Science, Bangalore, India

Tóm tắt

Neuropeptides, as the name suggests, are small peptides released by neurons that allow them to communicate with each other. These small peptides modulate the activity of neurons, in turn, allowing the modulation of multiple behaviors. Here, we describe how neuropeptides are made and go on to discuss how these peptides function in an organism. We also highlight the specific roles of neuropeptides in modulating the locomotory behavior of the free-living nematode, Caenorhabditis elegans.

Tài liệu tham khảo

C Li and K Kim, Neuropeptides, WormBook, pp.1–36, 2008.

Basic Neurochemistry, 6th ed (Molecular, Cellular and Medical Aspects), 1999; Lippincott-Raven.

E E Chufán, M De, B A Eipper, R E Mains and L M Amzel, Amidation of bioactive peptides: The structure of the lyase domain of the amidating enzyme, Structure, Vol.17, No.7, pp.965–973, 2009.

A Bhardwaj, S Thapliyal, Y Dahiya and K Babu, FLP-18 functions through the G-protein-coupled receptors NPR-1 and NPR-4 to modulate reversal length in Caenorhabditis elegans, J. Neurosci., Vol.38, No.20, pp.4641–1654, 2018.

M F Beal and J B Martin, Neuropeptides in neurological disease, Ann Neurol., Vol.20, No.5, pp.547–565, 1986.

A A van der Klaauw, Neuropeptides in obesity and metabolic disease, Clinical Chemistry, Vol.64, No.1, pp.173–182, 2018.

N Shibata, T Ohnuma, B Kuerban, M Komatsu and H Arai, Genetic association between ghrelin polymorphisms and Alzheimer’s disease in a Japanese population, Dement Geriatr Cogn Disord., Vol.32, No.3, pp.178–181, 2011.

Thông tin
Thông tin xuất bản

Resonance

Tập 25

1741-1752

Thông tin tác giả