Erin M. Gibson1, David Purger1,2, Christopher W. Mount1,3, Andrea Goldstein1, Grant L. Lin1,3, Lauren Wood1, Ingrid Inema1, Sarah E. Miller1, Gregor Bieri3, J. Bradley Zuchero4, Ben A. Barres4, Pamelyn J. Woo1, Hannes Vogel5, Michelle Monje1
1Departments of Neurology, Neurosurgery, and Pediatrics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
2Graduate Program in Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
3Graduate Program in Neuroscience, Stanford University School of Medicine, Stanford, CA 94305, USA.
4Departments of Neurobiology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
5Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Tóm tắt
On-Demand Activity
Oligodendroglia ensheath axons in the brain with myelin, which provides the insulation that speeds up transmission of neuronal electrical impulses. The process of myelination in the human brain goes on for decades, concurrent with all manner of brain development and cognitive activity.
Gibson
et al.
(p.
10.1126/science.1252304
, published online 10 April; see the Perspective by
Bechler and ffrench-Constant
) used optogenetics to study myelination in response to neural activity. Electrical activity in the motor cortex of the brain of awake mice led to proliferation and differentiation of oligodendrocytes and consequently increased myelination and alterations in motor response.
