Neuroleptic medication and reduced risk of prostate cancer in schizophrenic patients
Tóm tắt
A decreased incidence of cancer of the prostate has been demonstrated in a cohort of 6168 chronic schizophrenic patients followed up from 1957 to 1984. A case‐control study was performed based on this cohort to determine the possible influence of neuroleptic treatment and other factors on the risk of developing prostate cancer. Thirty‐eight male schizophrenic patients who had developed prostate cancer during the observation period were compared with 76 age‐ and sex‐matched controls from the same cohort. The only significant association was that of a reduced risk of prostate cancer among those who had been treated with a cumulative dose of high‐dose phenothiazines (primarily chlorpromazine) of 15 g or more. These patients had been treated with an average daily dose of 145 mg chlorpromazine for an average of 12.5 years. No other significant risk factors were identified.
Từ khóa
Tài liệu tham khảo
Rose DP., 1986, Dietary fat and cancer, 43
Rotkin JD., 1977, Studies on the epidemiology of prostatic cancer: expanded sampling, Cancer Treat Rep, 61, 173
Schuman LM, 1977, Epidemiologic study of prostatic cancer: preliminary report, Cancer Treat Rep, 61, 181
Hirayama T., 1979, Epidemiology of prostate cancer with special reference to the role of diet, Natl Cancer Inst Monogr, 53, 149
Graham S, 1983, Diet in the epidemiology of carcinoma of the prostate gland, J Natl Cancer Inst, 70, 687
Dupont A, 1986, Psychiatric case registers in public health. A worldwide inventory 1960–1985, 229
Mortensen PB., 1988, Ambidirectional studies – an extension of longitudinal studies in psychiatry, Psychiatr Dev, 2, 173
Breslow NE, 1980, Statistical methods in cancer research. The analysis of case‐control studies
Lührs W, 1962, Über die Kombinationsbehandlung mit entkoppelnden Substanzen bei malignen Tumoren, Krebsarzt, 17, 405
Eicke W‐J., 1975, Günstige Verläufe bei Karzinompatienten unter zusätzlicher Behandlung mit Phenothiazinderivaten, Med Klin, 70, 186
Hilf R, 1971, Effect of fluphenazine HC1 on R3230AC mammary carcinoma and mammary glands of the rat, Cancer Res, 31, 1111
Kanzawa F, 1970, Relationship between antitumor activity and chemical structure in psychotropic agents, Gann, 61, 529
Kanzawa F, 1972, Antitumor activity of haloacetylphenothiazines against ascites sarcoma‐180, Gann, 63, 225
Pamukcu AM, 1971, Phenothiazine inhibition of intestinal and urinary bladder tumors induced in rats by braken fern, J Natl Cancer Inst, 47, 155
Driscoll JS, 1978, Psychotropic drugs as potential antitumor agents: a selective screening study, Cancer Treat Rep, 62, 45
Akiyama S, 1986, Circumvention of multiple‐drug resistance in human cancer cells by thioridazine, trifluoperazine, and chlorpromazine, J Natl Cancer Inst, 76, 839
Miller RL, 1988, Clinical modulation of doxorubicin resistance by the calmodulininhibitor, trifluoperazine: a phase I/II trial, J Clin Oncol, 6, 880, 10.1200/JCO.1988.6.5.880
Griffiths K, 1987, Cancer of the prostate: endocrine factors, Oxf Rev Reprod Biol, 9, 192
Powchik P, 1987, Handbook of schizophrenia, Vol 2, Neurochemistry and neuropharmacology of schizophrenia, 337
Uhl E., 1967, Kostundersøgelser i institutioner, 241
Baldessarini RJ., 1985, The pharmacological basis of therapeutics, 387