Neurobiological research in psychiatry—classification of dimensions of learning mechanisms instead of reification of categories?

e-Neuroforum - Tập 17 Số 4 - Trang 88-94 - 2011
Andreas Heinz1, Anne Beck1
1Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Charité Campus Mitte Charitéplatz 1, 10117 Berlin, Germany

Tóm tắt

Abstract Neuroscientific research in mental disorders is plagued by unclear nosological boundaries, phenotypic diversity, and high intra- and interindividual variability of identified neurobi­ological correlates. Likewise, genotypes asso­ciated with an increased risk for, e.g., schizophrenia are regularly found to also increase the risk for uni- and/or bipolar affective dis­orders. Therefore, one major research strategy of the last decade was to avoid correlation of genetic variation with complex clinical dis­orders and instead to focus on so-called intermediate or endophenotypes, i.e., neurobiological variables such as in vivo receptor expression or neuronal activation patterns, which are hypothetically more closely related to direct gene effects. We describe one such attempt and show that intermediate phenotypes such as brain activation patterns elic­ited by more or less complex cognitive tasks underlie complex regulations and influences and may thus not be the best target for neurobiological research. We suggest that in­stead of reifying brain activation as correlates of mental disorders, such disorders may best be conceptualized as results of alterations/biases in basic learning mechanisms (e.g., Pav­lovian and operant conditioning) interacting with individual and social environments and that neuroscientific research can rely on animal models and computationalized modeling to reveal their neurobiological correlates.

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