Neurobiological and psychiatric consequences of child abuse and neglect
Tóm tắt
The effects of early‐life trauma and its consequences for the treatment of depression are reviewed. The prevalence and clinical sequelae of early sexual and physical abuse, neglect and parental loss are described. An overview of preclinical studies that help guide clinical research and practice is presented. Human clinical studies on the neurobiological consequences of early trauma are summarized. Moderating factors, such as genetic variation and sex differences, are discussed. The few current treatment outcome studies relevant to this research area are described. Guidance for the management of patients with depression and a history of child abuse and neglect are provided. Most patients who have experienced early traumatic experiences are likely best treated with a combination of psychotherapy and pharmacotherapy. This review is dedicated to the memory of Seymour Levine who pioneered the field of early experience research and to a considerable extent inspired the clinical studies described in this review. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 671–690, 2010.
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Tài liệu tham khảo
Briere J., 1996, Therapy for adults molested as children: Beyond survival
Briere J., 2002, The APSAC handbook of child maltreatment, 175
Briere J. &Woo R.(1991).Child abuse sequelae in adult psychiatric emergency room patients. Paper presented at the 99th Annual Convention of the American Psychological Association San Francisco CA.
Brown G. W., 1986, Depression in young people: Developmental and clinical perspective, 251
Caldji C., 2000, The effects of early rearing environment on the development of GABA‐A and central benzodiazepine receptor levels and novelty‐induced fearfulness in the rat, Neuropsychopharmacology, 22, 219, 10.1016/S0893-133X(99)00110-4
Carver C. M., 1989, The impact of group therapy for adult survivors of childhood sexual abuse, Canadian Journal of Psychiatry, 34, 753, 10.1177/070674378903400802
Caspi A., 2003, Influence of life stress on depression: Moderation by a polymorphism in the 5‐HTT gene, Science, 18, 291
Children's Bureau, Administration of Children, Youth, and Families. U.S. Department of Health and Human Services, 2006, Child Maltreatment 2004
Craighead W. E., 2003, Handbook of Psychology: vol. 8. Clinical Psychology, 279, 10.1002/0471264385.wei0811
Greenberg L. S., 1997, Working with the emotions in psychotherapy
Huot R. L., 2004, Foster litters prevent hypothalamic–pituitary–adrenal axis sensitization mediated by neonatal maternal separation, Psychoneuroendocrinology, 29, 279, 10.1016/S0306-4530(03)00028-3
Kaufman J., 2000, Handbook of Infant Mental Health, 195
Kendall‐Tacket K. A., 1993, Impact of sexual abuse on children: A review and synthesis of recent empirical studies, Psychological Bulletin, 113, 164, 10.1037/0033-2909.113.1.164
Ladd C. O., 2000, Progress in brain research: The biological basis for mind body interactions, 81, 10.1016/S0079-6123(08)62132-9
Linehan M. M., 1993, Cognitive‐behavioral treatment of borderline personality disorder
Lyons D. M., 2010, Animal models of early‐life stress: Implications for understanding resilience, Developmental Psychobiology
Nathan P. E., 2002, A guide to treatments that work, 164
National Child Abuse and Neglect Data System. (2007).Department of Health & Human Services. Child Maltreatment Report 2007 http://www.acf.hhs.gov/programs/cb/stats_research/index.htm#can.
Nemeroff C. B., 2004, Neurobiological consequences of childhood trauma, The Journal of Clinical Psychiatry, 65, 18
Nemeroff C. B., 2005, The neurobiology of depression: Inroads to treatment and new drug discovery, The Journal of Clinical Psychiatry, 66, 5
Schatzberg A. F., 2004, Textbook of Psychopharmacology
Segal Z. V., 2002, Mindfulness‐based cognitive therapy for depression—A new approach to preventing relapse
Wilsnak S. C., 1984, Alcohol problems in women
Young E. A., 1998, Sex differences and the HPA axis: Implications for psychiatric disease, Journal of Gender Specific Medicine, 1, 21
Young J. E., 1990, Schema questionnaire
Young J. E., 2003, Schema Therapy: A Practitioner's Guide