Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome

American Journal of Medical Genetics, Part C: Seminars in Medical Genetics - Tập 142C Số 3 - Trang 158-172 - 2006
George T. Capone1,2, Parag Goyal3,4, William J. Ares3,4, Emily Lannigan5
1George Capone, M.D. has been Director of the Down Syndrome Clinic (DSC) at Kennedy Krieger Institute since 1990. His primary interests include characterization of neurobehavioral phenotypes, diagnosis and management of complex neurodevelopmental and behavioral conditions, and pharmacologic interventions.
2Kennedy Krieger Institute, 707 N. Broadway, Baltimore MD 21205.
3Parag Goyal and William Ares worked as Research Associates with Dr. Capone in the DSC
4they have recently graduated from Johns Hopkins University.
5Emily Lannigan also worked as a Research Associate in the DSC and recently graduated from Loyola College in Maryland.

Tóm tắt

AbstractThe term dual‐diagnosis refers to a person with mental retardation and a psychiatric disorder. Most children with Down syndrome (DS) do not have a psychiatric or neurobehavioral disorder. Current prevalence estimates of neurobehavioral and psychiatric co‐morbidity in children with DS range from 18% to 38%. We have found it useful to distinguish conditions with a pre‐pubertal onset from those presenting in the post‐pubertal period, as these are biologically distinct periods each with a unique vulnerability to specific psychiatric disorders. Due to the increased recognition that psychiatric symptoms may co‐occur with mental retardation, and are not inextricably linked to cognitive impairment, these conditions are considered treatable, in part, under a medical model. Improvement in physiologic regulation, emotional stability, and neurocognitive processing is one of the most elusive but fundamental goals of pharmacologic intervention in these disorders. © 2006 Wiley‐Liss, Inc.

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American Journal of Medical Genetics, Part C: Seminars in Medical Genetics

Tập 142C Số 3

158-172

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