Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke

Neural Plasticity - Tập 2017 - Trang 1-12 - 2017
Ming Xiao1, Qiang Li2, Hua Feng2, Le Zhang3, Yujie Chen2
1College of Computer and Information Science, Southwest University, Chongqing, China
2Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China
3College of Computer Science, Sichuan University, Chengdu, China

Tóm tắt

During the initial stages of hemorrhagic stroke, including intracerebral hemorrhage and subarachnoid hemorrhage, the reflex mechanisms are activated to protect cerebral perfusion, but secondary dysfunction of cerebral flow autoregulation will eventually reduce global cerebral blood flow and the delivery of metabolic substrates, leading to generalized cerebral ischemia, hypoxia, and ultimately, neuronal cell death. Cerebral blood flow is controlled by various regulatory mechanisms, including prevailing arterial pressure, intracranial pressure, arterial blood gases, neural activity, and metabolic demand. Evoked by the concept of vascular neural network, the unveiled neural vascular mechanism gains more and more attentions. Astrocyte, neuron, pericyte, endothelium, and so forth are formed as a communicate network to regulate with each other as well as the cerebral blood flow. However, the signaling molecules responsible for this communication between these new players and blood vessels are yet to be definitively confirmed. Recent evidence suggested the pivotal role of transcriptional mechanism, including but not limited to miRNA, lncRNA, exosome, and so forth, for the cerebral blood flow autoregulation. In the present review, we sought to summarize the hemodynamic changes and underline neural vascular mechanism for cerebral blood flow autoregulation in stroke-prone state and after hemorrhagic stroke and hopefully provide more systematic and innovative research interests for the pathophysiology and therapeutic strategies of hemorrhagic stroke.

Từ khóa


Tài liệu tham khảo

10.1016/S1474-4422(05)70283-0

10.1097/00003246-199310000-00032

10.1161/STROKEAHA.112.655910

10.1161/str.0b013e3181ec611b

10.1212/WNL.0b013e3182648a79

10.1093/brain/awr172

10.1002/ana.22668

10.1161/STROKEAHA.109.566257

10.1212/01.wnl.0000345666.83318.03

10.1161/STROKEAHA.111.000662

10.1016/j.pneurobio.2010.08.001

10.1161/01.STR.0000247868.97078.10

10.1016/j.jocn.2005.06.005

10.1038/ncpneuro0490

10.1161/STROKEAHA.108.519942

10.1016/S1474-4422(11)70108-9

10.1161/STROKEAHA.108.533315

10.1007/s12035-010-8155-z

10.1161/STROKEAHA.108.534404

10.1038/nrneurol.2012.210

10.1016/j.pneurobio.2013.09.002

10.1159/000158774

10.1016/j.brainres.2011.03.068

2012, Chinese Journal of Clinical Anatomy, 30, 176

2012, Chinese Journal of Clinical Anatomy, 35, 137

10.1007/s10571-008-9316-8

10.1227/01.neu.0000065154.04824.9e

10.3171/jns.2002.97.4.0896

10.1038/jcbfm.2011.154

10.1227/01.neu.0000337579.05110.f4

10.1590/s0004-282x2009000600029

10.1016/j.pneurobio.2012.02.003

10.1038/sj.jcbfm.9600283

10.1016/j.wneu.2013.01.110

10.1161/STROKEAHA.112.662312

10.1179/016164102101199701

10.1016/j.jmv.2012.08.004

10.2169/internalmedicine.49.2789

10.1016/j.ajem.2008.01.021

2006, The Journal of the Association of Physicians of India, 54, 42

10.1016/j.jocn.2007.03.024

10.1017/s0317167100008167

10.1227/http://01.NEU.0000334426.87024.DD

10.1212/01.wnl.0000314688.26295.03

10.1007/s11011-012-9369-8

10.2176/nmc.51.97

10.1016/j.clineuro.2008.03.001

10.1227/01.NEU.0000335777.14055.71

10.1161/01.STR.0000131657.08655.ce

10.2176/nmc.47.70

10.2176/nmc.46.277

10.1161/hypertensionaha.113.01063

10.1161/01.hyp.8.6_pt_2.ii36

10.1161/01.hyp.8.2.142

10.1159/000158163

10.1111/j.1750-3639.2010.00467.x

1992, Journal of Hypertension Supplement, 10, S71

10.1016/s0006-8993(03)02632-5

10.1016/s0006-8993(96)01000-1

10.1016/0006-8993(90)90601-7

10.1161/01.res.64.4.658

10.1038/jcbfm.2012.194

10.1152/ajpheart.00630.2009

2005, Terapevticheskiĭ Arkhiv, 77, 22

10.1097/00006123-199803000-00008

10.1097/00000539-199603000-00028

10.1016/S0140-6736(11)60614-4

10.1016/j.ccl.2004.07.001

10.1161/01.CIR.0000091257.27563.32

2010, Giornale Italiano di Cardiologia (Rome), 11, 467

10.4158/EP.13.6.687

10.1016/j.pediatrneurol.2006.01.010

10.1111/j.1399-5448.2009.00529.x

10.1007/s12975-016-0469-3

10.1002/jcp.21508

10.1002/jnr.23475

10.1161/STROKEAHA.113.678474

10.1161/STROKEAHA.112.661728

10.1161/STROKEAHA.110.586537

10.1161/STROKEAHA.114.007265

10.1038/nrcardio.2014.58

10.1038/nature13217

10.1097/00006123-199707000-00036

10.3171/jns.1990.73.3.0410

10.1038/srep22070

10.1016/j.jstrokecerebrovasdis.2013.04.023

10.1038/nm.3407

10.1002/dvdy.20020

10.1152/ajpcell.00221.2004

10.1161/ATVBAHA.107.161521

10.1007/s12975-016-0504-4

10.1097/TP.0000000000000648

10.1007/s11892-014-0573-2

10.1371/journal.pone.0082900

10.1161/01.hyp.22.5.665

10.1161/STROKEAHA.115.011552

10.1155/2014/572430

10.1002/jcp.20362

10.1093/brain/aws172

10.1016/j.jtbi.2011.05.003

10.1016/s0014-5793(00)01220-5

10.1007/s12975-015-0444-4

10.4103/2045-9912.184713

10.1212/01.wnl.0000264931.34941.f0

10.1152/ajpheart.00451.2015

10.1161/CIRCRESAHA.109.197145

10.1007/s00701-002-1035-1

10.1227/00006123-200203000-00030

10.1161/01.STR.0000152271.21943.a2

10.1016/j.expneurol.2012.09.003

10.1016/j.tips.2007.05.006

10.3389/fnins.2014.00103

10.1097/00004647-200003000-00017

10.1038/jcbfm.2014.15

10.1161/STROKEAHA.107.500736

10.1038/jcbfm.2015.156

10.2741/330

10.1016/j.nbd.2009.12.021

10.4238/2012.January.27.1

10.1371/journal.pone.0139470

2004

10.1152/japplphysiol.00783.2012

10.1016/s0010-4825(01)00015-4

2011, Computing in Cardiology, 37, 605

10.1109/69.553163

2003

10.1007/s11517-007-0243-5

10.1016/j.physa.2004.12.040

2012, Harvard Business Review, 90, 60

10.1586/14737175.2015.1018893

10.7887/jcns.24.676

10.2176/nmc.ra.2016-0174

2012, International Journal of Stroke, 7, 61, 10.1111/j.1747-4949.2011.00731.x

10.1016/j.cmpb.2009.09.002

10.1007/978-3-540-89740-8_1

10.1016/j.matcom.2014.07.003

10.1002/cnm.1444

10.1093/bioinformatics/btu133

10.1186/1742-4682-8-46

10.1039/c6nr01637e

10.1504/ijdmb.2014.060050

10.1016/j.plrev.2017.01.007

10.1007/s00701-004-0408-z

10.1097/00006123-199505000-00009

10.1089/neu.1995.12.891

10.3171/jns.1992.76.2.0212

10.1007/s12028-012-9810-1

10.1016/s0301-0082(99)00057-x

10.1161/STROKEAHA.113.001231

10.1161/STR.0b013e3182587839

10.1038/ncpneuro0372

10.1161/01.str.0000015555.21285.db

10.3171/2009.8.FOCUS09154

10.3171/2013.8.JNS1337

10.1186/1745-6215-13-183

10.1007/978-3-211-85578-2_19

Thông tin
Thông tin xuất bản

Neural Plasticity

Tập 2017

1-12

Thông tin tác giả