Natural history of thyroid function in adults with Down syndrome – 10‐year follow‐up study

Journal of Intellectual Disability Research - Tập 51 Số 4 - Trang 312-317 - 2007
V. P. Prasher1, Gustavo A. Gomez1
1Greenfields, Kings Norton, Birmingham, UK

Tóm tắt

AbstractBackground  The natural history of thyroid function in adults with Down syndrome (DS) is unknown.Method  This study investigated annual thyroid function tests in 200 adults with DS over a 10‐year period.Results  Transient and persistent thyroid dysfunction was common. The 5‐ and 10‐year incidence of definite hypothyroidism was 0.9%−1.64% and 13.6%, respectively. Subclinical hypothyroidism was not found to be an early sign for definite hypothyroidism.Conclusions  Routine screening for adults with DS who are euthyroid can be reduced to every 5 years rather than the present policy of every 1–2 years.

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Tài liệu tham khảo

Cutler A. T., 1986, Thyroid function in young children with Down syndrome, American Journal of Diseases of Children, 140, 479

10.1136/adc.2004.049536

10.3104/reviews.95

10.1352/0895-8017(2005)110<23:MOTDID>2.0.CO;2

10.1016/0891-4222(91)90013-I

10.1007/BF02944192

10.1111/j.1469-8749.1993.tb11660.x

World Health Organization (WHO, 1992, The ICD‐10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Diagnostic Guidelines

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Journal of Intellectual Disability Research

Tập 51 Số 4

312-317

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