Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro

Food Science and Human Wellness - Tập 12 - Trang 1174-1183 - 2023
Xiaoyu Cai1, Songxue Wang1, Huali Wang2, Suwen Liu3, Guishan Liu4, Huibin Chen5, Ji Kang1, Hao Wang1
1State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China
2China National Center for Food Safety Risk Assessment, Beijing, 100022, China
3College of Food Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China
4School of Food and Wine, Ningxia University, Yinchuan 750021, China
5College of Life Sciences, Fujian Normal University, Fuzhou 350117, China

Tài liệu tham khảo

Dogra, 2021, Delivering a childhood obesity prevention intervention using Islamic religious settings in the UK: what is most important to the stakeholders?, Prev. Med. Rep., 22 Di Bonito, 2020, Elevated blood pressure, cardiometabolic risk and target organ damage in youth with overweight and obesity, Nutr. Metab. Cardiovasc. Dis., 30, 1840, 10.1016/j.numecd.2020.05.024 Yang, 2015, Prevalence of overweight and obesity in the United States, 2007-2012, JAMA Intern. Med., 175, 1412, 10.1001/jamainternmed.2015.2405 Yen, 2012, Toxicity of weight loss agents, J. Med. Toxicol., 8, 145, 10.1007/s13181-012-0213-7 Caroline, 2021, Effect of Allium sativum extract in combination-with orlistat on insulin resistance and disrupted metabolic hormones in high fat diet induced obese rats, Sci. African., 14 Shin, 2013, Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts, J. Agric. Food Chem, 61, 11532, 10.1021/jf403332e Feng, 2018, Citrus phytochemicals and their potential effects on the prevention and treatment of obesity: review and progress of the past 10 years, J. Food Bioact., 4, 99, 10.31665/JFB.2018.4165 Lin, 2017, Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae, Oncol. Rep., 38, 2877, 10.3892/or.2017.5965 Ren, 2016, Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats, Eur. J. Pharmacol., 773, 13, 10.1016/j.ejphar.2016.01.002 Yoshida, 2014, Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity, Biochem. Biophys. Res. Commun., 454, 95, 10.1016/j.bbrc.2014.10.038 Li, 2013, Traditional Chinese medicine network pharmacology: theory, methodology and application, Chin. J. Nat. Med., 11, 110, 10.3724/SP.J.1009.2013.00110 Ge, 2021, Naringenin prolongs lifespan and delays aging mediated by IIS and MAPK in Caenorhabditis elegans, Food Funct, 12, 12127, 10.1039/D1FO02472H Cells, 2020, Anti-obesity effect of ginkgo vinegar, a fermented product of ginkgo seed coat, in mice fed a high-fat diet and 3T3-L1 preadipocyte cells, Nutrients, 12, 1 Liu, 2021, Dietary supplementation of apple phlorizin attenuates the redox state related to gut microbiota homeostasis in C57BL/6J mice fed with a high-fat diet, J. Agric. Food Chem., 69, 198, 10.1021/acs.jafc.0c06426 Cheng, 2019, Lutein attenuates oxidative stress and inhibits lipid accumulation in free fatty acids-induced HepG2 cells by activating the AMPK pathway, J. Funct. Foods, 60, 10.1016/j.jff.2019.103445 Cheng, 2020, Ursolic acid alleviates lipid accumulation by activating the AMPK signaling pathway in vivo and in vitro, J. Food Sci, 85, 3998 Liu, 2020, Black rice (Oryza sativa L.) reduces obesity and improves lipid metabolism in C57BL/6J mice fed a high-fat diet, J. Funct. Foods, 64, 10.1016/j.jff.2019.103605 Pang, 2008, Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells, J. Biol. Chem., 283, 16051, 10.1074/jbc.M710114200 Huang, 2013, P53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells, Toxicol. Appl. Pharmacol., 267, 113, 10.1016/j.taap.2012.12.016 Wang, 2019, Apple phlorizin attenuates oxidative stress in Drosophila melanogaster, J. Food Biochem, 43, 1 Namkhah, 2021, Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight/obese patients with NAFLD? A randomised, double-blind, placebo-controlled, clinical trial, Int. J. Clin. Pract., 75, 1, 10.1111/ijcp.14852 Burke, 2018, Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr/mice, J. Lipid Res., 59, 1714, 10.1194/jlr.M087387 Zhang, 2019, Network pharmacology databases for traditional Chinese medicine: review and assessment, Front. Pharmacol., 10, 1 Assini, 2015, Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21, Endocrinology, 156, 2087, 10.1210/en.2014-2003 Hansi, 2015, Flavanone naringenin: an effective antihyperglycemic and antihyperlipidemic nutraceutical agent on high fat diet fed streptozotocin induced type 2 diabetic rats, J. Funct. Foods, 14, 363, 10.1016/j.jff.2015.02.005 Richard, 2013, Naringenin inhibits adipogenesis and reduces insulin sensitivity and adiponectin expression in adipocytes, Evid. Based Complementary Altern. Med., 2013, 1, 10.1155/2013/549750 Hardie, 2012, AMPK: a nutrient and energy sensor that maintains energy homeostasis, Nat. Rev. Mol. Cell Biol., 13, 251, 10.1038/nrm3311 Wu, 2012, Activation of the AMP-activated protein kinase (AMPK) by nitrated lipids in endothelial cells, PLoS One, 7, 1 Wan, 2014, Ethanol extract of cirsium japonicum attenuates hepatic lipid accumulation via AMPK activation in human HepG2 cells, Exp. Ther. Med., 8, 79, 10.3892/etm.2014.1698 M.I.N. Wang, Y. Chen, Z. Xiong, et al., Ginsenoside Rb1 inhibits free fatty acids‑induced oxidative stress and inflammation in 3T3-L1 adipocytes, 16 (2017) 9165-9172. https://doi.org/10.3892/mmr.2017.7710. Su, 2014, Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis, Am. J. Physiol.-Endocrinol. Metab., 306, 1264, 10.1152/ajpendo.00438.2013 Kalai, 2013, Antiobesity effects of an edible halophyte Nitraria retusa forssk in 3T3-L1 preadipocyte differentiation and in C57B6J/L mice fed a high fat diet-induced obesity, Evid. Based Complementary Altern. Med., 2013, 1, 10.1155/2013/368658 Ma, 2012, Effects of flavonoids in Morus indica on blood lipids and glucose in hyperlipidemia-diabetic rats, Chinese Herb. Med., 4, 314