Nanoengineered silica: Properties, applications and toxicity

Abbaszad Rafi, 2016, Eur. J. Pharm. Sci., 93, 64, 10.1016/j.ejps.2016.08.005 Ahmad Nor, 2015, Shaping nanoparticles with hydrophilic compositions and hydrophobic properties as nanocarriers for antibiotic delivery, ACS Cent. Sci., 1, 328, 10.1021/acscentsci.5b00199 Alvarez, 2014, Antibiotic-loaded silica nanoparticle-collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention, J. Mater. Chem. B, 2, 4660, 10.1039/c4tb00327f Alvarez Echazu, 2016, Advances in collagen, chitosan and silica biomaterials for oral tissue regeneration: from basics to clinical trials, J. Mater. Chem. B, 4, 6913, 10.1039/C6TB02108E An, 2015, Silica nanoparticle-based dual imaging colloidal hybrids: cancer cell imaging and biodistribution, Int. J. Nanomedicine, 215 Auger, 2011, A comparative study of non-covalent encapsulation methods for organic dyes into silica nanoparticles, Nanoscale Res. Lett., 6, 10.1186/1556-276X-6-328 Baek, 2016, Triple hit with drug carriers: pH- and temperature-responsive theranostics for multimodal chemo- and photothermal therapy and diagnostic applications, ACS Appl. Mater. Interfaces, 8, 8967, 10.1021/acsami.6b00963 Baeza, 2015, Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery, Expert Opin. Drug Deliv., 12, 319, 10.1517/17425247.2014.953051 Barahona, 2016, Multimethod approach for the detection and characterisation of food-grade synthetic amorphous silica nanoparticles, J. Chromatogr. A, 1432, 92, 10.1016/j.chroma.2015.12.058 Bertucci, 2015, Combined delivery of temozolomide and anti-miR221 PNA using mesoporous silica nanoparticles induces apoptosis in resistant glioma cells, Small, 11, 5687, 10.1002/smll.201500540 Bhattacharjee, S., Mahon, E., Harrison, S.M., McGetrick, J., Muniyappa, M., Carrington, S.D., Brayden, D.J., n.d. Nanoparticle passage through porcine jejunal mucus: Microfluidics and rheology. Nanomedicine Nanotechnol. Biol. Med. http://dx.doi.org/10.1016/j.nano.2016.11.017. Castillo, 2017, Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer, Expert Opin. Drug Deliv., 14, 229, 10.1080/17425247.2016.1211637 Ceresa, 2013, Functionalized mesoporous silica nanoparticles: a possible strategy to target cancer cells reducing peripheral nervous system uptake, Curr. Med. Chem., 20, 2589, 10.2174/0929867311320200007 Chen, 2014, Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy, Sci. Rep., 4, 5080, 10.1038/srep05080 Cheng, 2016, 5-Azacytidine delivered by mesoporous silica nanoparticles regulates the differentiation of P19 cells into cardiomyocytes, Nanoscale, 8, 2011, 10.1039/C5NR08560H Cheng, 2016, Dynamic in vivo SPECT imaging of neural stem cells functionalized with radiolabeled nanoparticles for tracking of glioblastoma, J. Nucl. Med., 57, 279, 10.2967/jnumed.115.163006 Cheng, 2015, Enzyme-induced and tumor-targeted drug delivery system based on multifunctional mesoporous silica nanoparticles, ACS Appl. Mater. Interfaces, 7, 9078, 10.1021/acsami.5b00752 Chen, 2013, Label-free luminescent mesoporous silica nanoparticles for imaging and drug delivery, Theranostics, 3, 650, 10.7150/thno.6668 Chen, 2015, Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles, Nanoscale, 7, 14080, 10.1039/C5NR03527A Chen, 2016, Multifunctional redox-responsive mesoporous silica nanoparticles for efficient targeting drug delivery and magnetic resonance imaging, ACS Appl. Mater. Interfaces, 8, 33829, 10.1021/acsami.6b11802 Chen, 2014, Enhanced plasmonic resonance energy transfer in mesoporous silica-encased gold nanorod for two-photon-activated photodynamic therapy, Theranostics, 4, 798, 10.7150/thno.8934 Chen, 2008, Age-related differences in pulmonary and cardiovascular responses to SiO 2 nanoparticle inhalation: nanotoxicity has susceptible population, Environ. Sci. Technol., 42, 8985, 10.1021/es800975u Choi, 2016, PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and celastrol in multi-targeted cancer therapy, Acta Biomater., 39, 94, 10.1016/j.actbio.2016.05.012 Cozzolino, 2016, Influence of colloidal silica nanoparticles on pullulan-coated BOPP film, Food Packag. Shelf Life, 8, 50, 10.1016/j.fpsl.2016.03.003 Croissant, 2016, Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging, J. Control. Release, 229, 183, 10.1016/j.jconrel.2016.03.030 Cui, 2013, Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment, Biomaterials, 34, 8511, 10.1016/j.biomaterials.2013.07.075 Dai, 2014, Redox-responsive nanocarrier based on heparin end-capped mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo, Langmuir, 30, 7867, 10.1021/la501924p Dekkers, 2011, Presence and risks of nanosilica in food products, Nanotoxicology, 5, 393, 10.3109/17435390.2010.519836 Delaval, 2015, Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia, Part. Fibre Toxicol., 12, 10.1186/s12989-014-0078-9 de Oliveira, 2016, Functionalized silica nanoparticles as an alternative platform for targeted drug-delivery of water insoluble drugs, Langmuir, 32, 3217, 10.1021/acs.langmuir.6b00214 de Souza Oliveira, 2016, Silica nanoparticles doped with anthraquinone for lung cancer phototherapy, J. Photochem. Photobiol. B, 165, 1, 10.1016/j.jphotobiol.2016.10.008 Durfee, 2016, Mesoporous silica nanoparticle-supported lipid bilayers (protocells) for active targeting and delivery to individual leukemia cells, ACS Nano, 10, 8325, 10.1021/acsnano.6b02819 Du, 2015, γ-PGA-coated mesoporous silica nanoparticles with covalently attached prodrugs for enhanced cellular uptake and intracellular gsh-responsive release, Adv. Healthc. Mater, 4, 771, 10.1002/adhm.201400726 Ebabe Elle, 2016, Functionalized mesoporous silica nanoparticle with antioxidants as a new carrier that generates lower oxidative stress impact on cells, Mol. Pharm., 13, 2647, 10.1021/acs.molpharmaceut.6b00190 El-Dakdouki, 2013, Development of drug loaded nanoparticles for tumor targeting. Part 2: Enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models, Nanoscale, 5, 3904, 10.1039/c3nr90022c EUROPEAN COMMISSION, 2007, Reference Document on Best Available Techniques for the Manufacture of Large Volume Inorganic Chemicals–Solids and Others industry. Chapter 5: Synthetic Amorphous Silica, 255 Fan, 2011, Targeted anticancer prodrug with mesoporous silica nanoparticles as vehicles, Nanotechnology, 22, 455102, 10.1088/0957-4484/22/45/455102 Fang, 2012, Pd nanosheet-covered hollow mesoporous silica nanoparticles as a platform for the chemo-photothermal treatment of cancer cells, Small, 8, 3816, 10.1002/smll.201200962 Fanizza, 2016, Fabrication of photoactive heterostructures based on quantum dots decorated with Au nanoparticles, Sci. Technol. Adv. Mater, 17, 98, 10.1080/14686996.2016.1153939 Farjadian, 2016, Hydroxyl-modified magnetite nanoparticles as novel carrier for delivery of methotrexate, Int. J. Pharm., 504, 110, 10.1016/j.ijpharm.2016.03.022 Feng, 2014, Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers, ACS Appl. Mater. Interfaces, 6, 8447, 10.1021/am501337s Fernando, 2015, Esterase- and pH-responsive poly([small beta]-amino ester)-capped mesoporous silica nanoparticles for drug delivery, Nanoscale, 7, 7178, 10.1039/C4NR07443B Foglia, 2011, Recent patents on the synthesis and application of silica nanoparticles for drug delivery, Recent Pat. Biotechnol., 5, 54, 10.2174/187220811795655887 Frasconi, 2013, Photoexpulsion of surface-grafted ruthenium complexes and subsequent release of cytotoxic cargos to cancer cells from mesoporous silica nanoparticles, J. Am. Chem. Soc., 135, 11603, 10.1021/ja405058y Fruijtier-Pölloth, 2016, The safety of nanostructured synthetic amorphous silica (SAS) as a food additive (E 551), Arch. Toxicol., 90, 2885, 10.1007/s00204-016-1850-4 Fu, 2016, Improving paclitaxel pharmacokinetics by using tumor-specific mesoporous silica nanoparticles with intraperitoneal delivery, Nanomedicine Nanotechnol. Biol. Med., 12, 1951, 10.1016/j.nano.2016.04.013 Gamcsik, 2012, Glutathione levels in human tumors, Biomark. Biochem. Indic. Expo. Response Susceptibility Chem., 17, 671 Gao, 2011, Nanogated vessel based on polypseudorotaxane-capped mesoporous silica via a highly acid-labile benzoic-imine linker, Symp. Innov. Polym. Control. Deliv. Conf. Abstr. First Symp. Innov. Polym. Control. Deliv., 152, e81 Gao, 2016, Fe3O4@mSiO2-FA-CuS-PEG nanocomposites for magnetic resonance imaging and targeted chemo-photothermal synergistic therapy of cancer cells, Dalton Trans., 45, 13456, 10.1039/C6DT01714B Gary-Bobo, 2012, Hyaluronic acid-functionalized mesoporous silica nanoparticles for efficient photodynamic therapy of cancer cells, Photodiagnosis Photodyn. Ther., 9, 256, 10.1016/j.pdpdt.2011.12.010 Ghosh Chaudhuri, 2012, Core/shell nanoparticles: classes, properties, synthesis mechanisms, Charact. Appl. Chem. Rev., 112, 2373 Giljohann, 2009, Drivers of biodiagnostic development, Nature, 462, 461, 10.1038/nature08605 Giménez, 2015, Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells, Langmuir, 31, 3753, 10.1021/acs.langmuir.5b00139 Gong, 2012, Methylation of PARP-1 promoter involved in the regulation of nano-SiO2-induced decrease of PARP-1 mRNA expression, Toxicol. Lett., 209, 264, 10.1016/j.toxlet.2012.01.007 Gong, 2010, SiO2 nanoparticles induce global genomic hypomethylation in HaCaT cells, Biochem. Biophys. Res. Commun., 397, 397, 10.1016/j.bbrc.2010.05.076 Gonzalez, 2014, Preliminary evaluation of median lethal concentrations of stöber silica particles with various sizes and surface functionalities towards fibroblast cells, Silicon Guha, 2016, pH responsive cylindrical MSN for oral delivery of insulin- design, fabrication and evaluation, Drug Deliv., 1 Gu, 2013, One-pot synthesis of mesoporous silica nanocarriers with tunable particle sizes and pendent carboxylic groups for cisplatin delivery, Langmuir, 29, 403, 10.1021/la3036264 Guo, 2012, The intracellular controlled release from bioresponsive mesoporous silica with folate as both targeting and capping agent, Nanoscale, 4, 3577, 10.1039/c2nr30425b Guttenberg, 2016, Biodistribution of inhaled metal oxide nanoparticles mimicking occupational exposure: a preliminary investigation using enhanced darkfield microscopy, J. Biophot., 9, 987, 10.1002/jbio.201600125 Hakeem, 2016, Cellulose conjugated FITC-labelled mesoporous silica nanoparticles: intracellular accumulation and stimuli responsive doxorubicin release, Nanoscale, 8, 5089, 10.1039/C5NR08753H Hanafi-Bojd, 2015, Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells, Eur. J. Pharm. Biopharm., 89, 248, 10.1016/j.ejpb.2014.12.009 Han, 2016, pH-responsive core–shell structured nanoparticles for triple-stage targeted delivery of doxorubicin to tumors, ACS Appl. Mater. Interfaces, 8, 23498, 10.1021/acsami.6b07173 Han, 2015, Hybrid lipid-capped mesoporous silica for stimuli-responsive drug release and overcoming multidrug resistance, ACS Appl. Mater. Interfaces, 7, 3342, 10.1021/am5082793 Heinemann, 2013, Bio-inspired silica-collagen materials: Applications and perspectives in the medical field, Biomater. Sci., 1, 688, 10.1039/c3bm00014a Huang, 2016, Hybrid Antifouling and Antimicrobial Coatings Prepared by Electroless Co-Deposition of Fluoropolymer and Cationic Silica Nanoparticles on Stainless Steel: Efficacy against Listeria monocytogenes, ACS Appl. Mater. Interfaces, 8, 15926, 10.1021/acsami.6b04187 Huang, 2012, Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes, Biomaterials, 33, 4370, 10.1016/j.biomaterials.2012.02.060 Huang, 2016, Fabrication of silica-coated hollow carbon nanospheres encapsulating Fe3O4 cluster for magnetical and MR imaging guided NIR light triggering hyperthermia and ultrasound imaging, ACS Appl. Mater. Interfaces, 8, 14470, 10.1021/acsami.6b04759 Hu, 2016, Asn-Gly-Arg-modified polydopamine-coated nanoparticles for dual-targeting therapy of brain glioma in rats, Oncotarget Adv., 7, 73681, 10.18632/oncotarget.12047 Huo, 2015, Au@SiO2 core–shell structure involved with methotrexate: Fabrication, biodegradation process and bioassay explore, Int. J. Pharm., 496, 965, 10.1016/j.ijpharm.2015.10.052 Hu, 2013, Multifunctional hybrid silica nanoparticles for controlled doxorubicin loading and release with thermal and pH dual response, J. Mater. Chem. B, 1, 1109, 10.1039/c2tb00223j Hu, 2017, Aptamer combined with fluorescent silica nanoparticles for detection of hepatoma cells, Nanoscale Res. Lett., 12, 10.1186/s11671-017-1890-6 Hwang, 2015, pH-Responsive isoniazid-loaded nanoparticles markedly improve tuberculosis treatment in mice, Small, 11, 5066, 10.1002/smll.201500937 Hwang, 2016, Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles, Colloids Surf. B Biointerfaces, 142, 290, 10.1016/j.colsurfb.2016.01.040 Iliopoulos, 2009, An epigenetic switch involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation, Cell, 139, 693, 10.1016/j.cell.2009.10.014 Jia, 2015, Multifunctional mesoporous silica nanoparticles mediated co-delivery of paclitaxel and tetrandrine for overcoming multidrug resistance, Int. J. Pharm., 489, 318, 10.1016/j.ijpharm.2015.05.010 Jia, 2012, Successfully tailoring the pore size of mesoporous silica nanoparticles: Exploitation of delivery systems for poorly water-soluble drugs, Int. J. Pharm., 439, 81, 10.1016/j.ijpharm.2012.10.011 Jiao, 2016, Fluorescent carbon dot modified mesoporous silica nanocarriers for redox-responsive controlled drug delivery and bioimaging, J. Colloid Interface Sci., 483, 343, 10.1016/j.jcis.2016.08.033 Jiao, 2016, Redox and pH dual-responsive PEG and chitosan-conjugated hollow mesoporous silica for controlled drug release, Mater. Sci. Eng. C, 67, 26, 10.1016/j.msec.2016.04.091 Jiao, 2013, Redox- and temperature-controlled drug release from hollow mesoporous silica nanoparticles, Chem. – Eur. J., 19, 15410, 10.1002/chem.201301060 Jiao, 2015, Tumor-targeting multifunctional rattle-type theranostic nanoparticles for MRI/NIRF bimodal imaging and delivery of hydrophobic drugs, Small, 11, 1962, 10.1002/smll.201402297 Jin, 2017, Superhydrophobic silica nanoparticles as ultrasound contrast agents, Ultrason. Sonochem, 36, 262, 10.1016/j.ultsonch.2016.12.001 Jin, 2017, Nanosystem composed with MSNs, gadolinium, liposome and cytotoxic peptides for tumor theranostics, Colloids Surf. B Biointerfaces, 151, 240, 10.1016/j.colsurfb.2016.12.024 Jokerst, 2012, Photoacoustic imaging of mesenchymal stem cells in living mice via silica-coated gold nanorods, ACS Nano, 6, 5920, 10.1021/nn302042y Kamkaew, 2016, Cerenkov radiation induced photodynamic therapy using chlorin e6-loaded hollow mesoporous silica nanoparticles, ACS Appl. Mater. Interfaces, 8, 26630, 10.1021/acsami.6b10255 Keene, 2007, RNA regulons: coordination of post-transcriptional events, Nat. Rev. Genet., 8, 533, 10.1038/nrg2111 Khatoon, 2016, Zwitterionic mesoporous nanoparticles with a bioresponsive gatekeeper for cancer therapy, Zwitterionic Mater, 40, 282 Kim, 2016, Nanotherapeutics of PTEN inhibitor with mesoporous silica nanocarrier effective for axonal outgrowth of adult neurons, ACS Appl. Mater. Interfaces, 8, 18741, 10.1021/acsami.6b06889 Koneru, 2015, Tetracycline-Containing MCM-41 Mesoporous Silica Nanoparticles for the Treatment of Escherichia coli, Molecules, 20, 10.3390/molecules201119650 Kuthati, 2015, pH-Triggered controllable release of silver–Indole-3 acetic acid complexes from mesoporous silica nanoparticles (IBN-4) for effectively killing malignant bacteria, Mol. Pharm., 12, 2289, 10.1021/mp500836w Kwon, 2016, Dual-color emissive upconversion nanocapsules for differential cancer bioimaging in vivo, ACS Nano, 10, 1512, 10.1021/acsnano.5b07075 Laranjeira, 2017, Enhanced biosafety of silica coated gadolinium based nanoparticles, J. Mater. Sci. Mater. Med., 28, 10.1007/s10856-017-5855-1 Laterza, 2013, Circulating miR-122 as a potential biomarker of liver disease, Biomark. Med., 7, 205, 10.2217/bmm.12.107 Lee, 2014, Ca2+-Dependent intracellular drug delivery system developed with “Raspberry-type” particles-on-a-particle comprising mesoporous silica core and α-synuclein-coated gold nanoparticles, ACS Nano, 8, 8887, 10.1021/nn5034955 Lee, 2016, Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles, Colloids Surf. B Biointerfaces, 143, 511, 10.1016/j.colsurfb.2016.03.060 Lee, 2017, Biokinetics of food additive silica nanoparticles and their interactions with food components, Colloids Surf. B Biointerfaces, 150, 384, 10.1016/j.colsurfb.2016.11.001 Leelahavanichkul, 2015, Serum miRNA-122 in acute liver injury induced by kidney injury and sepsis in CD-1 mouse models: miRNA-122 in ALF induced by AKI, Hepatol. Res., 45, 1341, 10.1111/hepr.12501 Lee, 2013, Rapamycin enhances TNF-α-induced secretion of IL-6 and IL-8 through suppressing PDCD4 degradation in orbital fibroblasts, Curr. Eye Res., 38, 699, 10.3109/02713683.2012.750368 2015 Li, 2014, Thermoresponsive copolymer/SiO2 nanoparticles with dual functions of thermally controlled drug release and simultaneous carrier decomposition, Chem. – Eur. J., 20, 12945, 10.1002/chem.201402836 Li, 2012, Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin, Int. J. Nanomedicine, 7, 5995, 10.2147/IJN.S38043 Li, 2013, Reduction-responsive drug delivery based on mesoporous silica nanoparticle core with crosslinked poly(acrylic acid) shell, Mater. Sci. Eng. C, 33, 3426, 10.1016/j.msec.2013.04.033 Li, 2013, A vitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting, Chem. Commun., 49, 5823, 10.1039/c3cc41072b Lima, 2015, Micro-/nano-structured superhydrophobic surfaces in the biomedical field: part I: basic concepts and biomimetic approaches, Nanomed, 10, 103, 10.2217/nnm.14.174 Lim, 2016, Recent advances in multifunctional silica-based hybrid nanocarriers for bioimaging and cancer therapy, Nanoscale, 8, 12510, 10.1039/C5NR07853A Lin, 2012, Mesoporous silica nanoparticles for the improved anticancer efficacy of cis-platin, Int. J. Pharm., 429, 138, 10.1016/j.ijpharm.2012.03.026 Li, 2014, Mesoporous silica nanoparticles coated by layer-by-layer self-assembly using cucurbit[7]uril for in vitro and in vivo anticancer drug release, Chem. Mater, 26, 6418, 10.1021/cm503304p Li, 2015, pH and glutathione dual-responsive dynamic cross-linked supramolecular network on mesoporous silica nanoparticles for controlled anticancer drug release, ACS Appl. Mater. Interfaces, 7, 28656, 10.1021/acsami.5b10534 Li, 2016, Folate-functionalized magnetic-mesoporous silica nanoparticles for drug/gene codelivery to potentiate the antitumor efficacy, ACS Appl. Mater. Interfaces, 8, 13748, 10.1021/acsami.6b02963 Liu, 2015, Multifunctional NaYF4:Yb, Er@mSiO2@Fe3O4-PEG nanoparticles for UCL/MR bioimaging and magnetically targeted drug delivery, Nanoscale, 7, 1839, 10.1039/C4NR05342G Liu, 2016, In vitro and in vivo evaluation of puerarin-loaded PEGylated mesoporous silica nanoparticles, Drug Dev. Ind. Pharm., 42, 2031, 10.1080/03639045.2016.1190742 Liu, 2014, Cu2-xSe@mSiO2-PEG core-shell nanoparticles: a low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density, Nanoscale, 6, 4361, 10.1039/C3NR06160D Liu, 2015, Fabrication of multifunctional SiO2@GN-serum composites for chemo-photothermal synergistic therapy, ACS Appl. Mater. Interfaces, 7, 112, 10.1021/am507658v Liu, 2015, Multicolor (Vis-NIR) mesoporous silica nanospheres linked with lanthanide complexes using 2-(5-bromothiophen)imidazo[4,5-f][1,10]phenanthroline for in vitro bioimaging, Dalton Trans., 44, 237, 10.1039/C4DT02444C Lokeshwar, 2014, Targeting hyaluronic acid family for cancer chemoprevention and therapy, Adv. Cancer Res., 123, 35, 10.1016/B978-0-12-800092-2.00002-2 Lungare, 2016, Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery, Int. J. Pharm., 513, 280, 10.1016/j.ijpharm.2016.09.042 Luo, 2014, Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity, Biomaterials, 35, 7951, 10.1016/j.biomaterials.2014.05.058 Lv, 2015, A yolk-like multifunctional platform for multimodal imaging and synergistic therapy triggered by a single near-infrared light, ACS Nano, 9, 1630, 10.1021/nn5063613 Lv, 2016, Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy, Drug Des. Devel. Ther., 10, 3933, 10.2147/DDDT.S116286 Maggini, 2016, Breakable mesoporous silica nanoparticles for targeted drug delivery, Nanoscale, 8, 7240, 10.1039/C5NR09112H Mamaeva, 2013, Mesoporous silica nanoparticles in medicine—Recent advances, Adv. Drug Deliv. Rev., 65, 689, 10.1016/j.addr.2012.07.018 Ma’mani, 2014, Curcumin-loaded guanidine functionalized PEGylated I3ad mesoporous silica nanoparticles KIT-6: Practical strategy for the breast cancer therapy, Eur. J. Med. Chem., 83, 646, 10.1016/j.ejmech.2014.06.069 Ma, 2015, Bi2S3-embedded mesoporous silica nanoparticles for efficient drug delivery and interstitial radiotherapy sensitization, Biomaterials, 37, 447, 10.1016/j.biomaterials.2014.10.001 Martínez-Carmona, 2015, Smart mesoporous nanomaterials for antitumor therapy, Nanomaterials, 5, 1906, 10.3390/nano5041906 Ma, 2013, Integrated hollow mesoporous silica nanoparticles for target drug/siRNA co-delivery, Chem. – Eur. J., 19, 15593, 10.1002/chem.201302736 Mebert, 2016, Silica core-shell particles for the dual delivery of gentamicin and rifamycin antibiotics, J. Mater. Chem. B, 4, 3135, 10.1039/C6TB00281A Mebert, 2013, Controlling the interaction between cells and silica nanoparticles, J. Biomater. Tissue Eng., 3, 108, 10.1166/jbt.2013.1069 Mekaru, 2015, Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy, Multifunct. Nanodevices Nanobots Bioimaging Cancer Diagn. Stem Cell Ther. Regen. Med., 95, 40 Meng, 2013, Codelivery of an Optimal drug/siRNA combination using mesoporous silica nanoparticles to overcome drug resistance in breast cancer in vitro and in vivo, ACS Nano, 7, 994, 10.1021/nn3044066 Meng, 2015, Use of a lipid-coated mesoporous silica nanoparticle platform for synergistic gemcitabine and paclitaxel delivery to human pancreatic cancer in mice, ACS Nano, 9, 3540, 10.1021/acsnano.5b00510 Merget, 2002, Health hazards due to the inhalation of amorphous silica, Arch. Toxicol., 75, 625, 10.1007/s002040100266 Mitra, 2015, Microwave synthesis of ZnO@mSiO2 for detailed antifungal mode of action study: Understanding the insights into oxidative stress, J. Colloid Interface Sci., 444, 97, 10.1016/j.jcis.2014.12.041 Mody, 2013, Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery, Nanoscale, 5, 5167, 10.1039/c3nr00357d Hanafi-Bojd, 2016, Co-delivery of epirubicin and siRNA using functionalized mesoporous silica nanoparticles enhances in vitro and in vivo drug efficacy, Curr. Drug Deliv., 13, 1 Muhammad, 2014, Responsive delivery of drug cocktail via mesoporous silica nanolamps, J. Colloid Interface Sci., 434, 1, 10.1016/j.jcis.2014.07.024 Muñoz-Gámez, 2015, Synergistic cytotoxicity of the poly (ADP-ribose) polymerase inhibitor ABT-888 and temozolomide in dual-drug targeted magnetic nanoparticles, Liver Int., 35, 1430, 10.1111/liv.12586 Murugan, 2016, Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in bresat cancer cells: an improved nanomedicine strategies, Sci. Rep., 6, 34053, 10.1038/srep34053 Nafisi, 2015, Perspectives on percutaneous penetration: Silica nanoparticles, Nanotoxicology, 9, 643, 10.3109/17435390.2014.958115 Nagano, 2013, Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage, Nanotechnology, 24, 405102, 10.1088/0957-4484/24/40/405102 Nagesetti, 2016, Multifunctional organically modified silica nanoparticles for chemotherapy, adjuvant hyperthermia and near infrared imaging, Colloids Surf. B Biointerfaces, 147, 492, 10.1016/j.colsurfb.2016.07.048 Nday, 2015, Quercetin encapsulation in modified silica nanoparticles: potential use against Cu(II)-induced oxidative stress in neurodegeneration, J. Inorg. Biochem., 145, 51, 10.1016/j.jinorgbio.2015.01.001 Nilsen-Nygaard, 2015, Chitosan: gels and interfacial properties, Polymers, 7, 10.3390/polym7030552 Oberdörster, 2005, Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles, Environ. Health Perspect., 113, 823, 10.1289/ehp.7339 Oberdörster, 2007, Toxicology of nanoparticles: A historical perspective, Nanotoxicology, 1, 2, 10.1080/17435390701314761 Pan, 2012, Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles, J. Am. Chem. Soc., 134, 5722, 10.1021/ja211035w Pan, 2013, Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles, Biomaterials, 34, 2719, 10.1016/j.biomaterials.2012.12.040 Paris, 2015, Polymer-grafted mesoporous silica nanoparticles as ultrasound-responsive drug carriers, ACS Nano, 9, 11023, 10.1021/acsnano.5b04378 Pina, 2015, Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review, Adv. Mater, 27, 1143, 10.1002/adma.201403354 Priebe, 2016, Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells, Nanomedicine Nanotechnol. Biol. Med. Prodi, 2016, Multimodal near-infrared-emitting PluS Silica nanoparticles with fluorescent, photoacoustic, and photothermal capabilities, Int. J. Nanomedicine, 11, 4865, 10.2147/IJN.S107479 Purbia, 2015, Yolk/shell nanoparticles: classifications, synthesis, properties, and applications, Nanoscale, 7, 19789, 10.1039/C5NR04729C Qu, 2015, Targeted delivery of doxorubicin to mitochondria using mesoporous silica nanoparticle nanocarriers, Nanoscale, 7, 16677, 10.1039/C5NR05139H Ravera, 2016, Functionalized nonporous silica nanoparticles as carriers for Pt(iv) anticancer prodrugs, Dalton Trans., 10.1039/C6DT03133A Reamonbuettner, 2008, The next innovation cycle in toxicogenomics: Environmental epigenetics, Mutat. Res. Mutat. Res., 659, 158, 10.1016/j.mrrev.2008.01.003 Roderburg, 2015, Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases, Liver Int., 35, 1172, 10.1111/liv.12627 Ryu, 2014, Evaluation of silica nanoparticle toxicity after topical exposure for 90 days, Int. J. Nanomedicine, 9, 127 Sahu, 2013, Multifunctional magnetic fluorescent hybrid nanoparticles as carriers for the hydrophobic anticancer drug 5-fluorouracil, Dalton Trans., 42, 2224, 10.1039/C2DT31812A Santo-Orihuela, 2016, Nanotoxicological Effects of SiO2 Nanoparticles on Spodoptera frugiperda Sf9 Cells, Curr. Pharm. Biotechnol., 17, 465, 10.2174/138920101705160303165604 Sapino, 2015, Mesoporous silica as topical nanocarriers for quercetin: characterization and in vitro studies, Eur. J. Pharm. Biopharm., 89, 116, 10.1016/j.ejpb.2014.11.022 Sarkar, 2016, Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells, Biochim. Biophys. Acta BBA - Gen. Subj., 1860, 2065, 10.1016/j.bbagen.2016.07.001 SCCS, 2016, Opinion of the Scientific Committee on Consumer Safety (SCCS) – Revision of the opinion on the safety of the use of Silica, Hydrated Silica, and Silica Surface Modified with Alkyl Silylates (nano form) in cosmetic products, Regul. Toxicol. Pharmacol., 74, 79, 10.1016/j.yrtph.2015.11.005 Schick, 2014, Inorganic Janus particles for biomedical applications, Beilstein J. Nanotechnol., 5, 2346, 10.3762/bjnano.5.244 Schulz, 2012, Intracellular sensing and cell diagnostics using fluorescent silica nanoparticles, Soft Matter, 8, 2579, 10.1039/c2sm06862a Sepeur, 2008 Shahabi, 2015, Utilizing the protein corona around silica nanoparticles for dual drug loading and release, Nanoscale, 7, 16251, 10.1039/C5NR04726A She, 2015, Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery, J. Colloid Interface Sci., 445, 151, 10.1016/j.jcis.2014.12.053 Singh, 2014, Sol-Gel processing of silica nanoparticles and their applications, Adv. Colloid Interface Sci., 214, 17, 10.1016/j.cis.2014.10.007 Singh, 2015, Cytotoxicity of curcumin silica nanoparticle complexes conjugated with hyaluronic acid on colon cancer cells, Int. J. Biol. Macromol., 74, 162, 10.1016/j.ijbiomac.2014.11.037 Singh, 2014, Enhancement of phototoxicity of curcumin in human oral cancer cells using silica nanoparticles as delivery vehicle, Lasers Med. Sci., 29, 645, 10.1007/s10103-013-1357-7 Sinha, 2014, Dextran-gated, multifunctional mesoporous nanoparticle for glucose-responsive and targeted drug delivery, ACS Appl. Mater. Interfaces, 6, 22183, 10.1021/am505848p Smulders, 2016, Body distribution of SiO2–Fe3O4 core-shell nanoparticles after intravenous injection and intratracheal instillation, Nanotoxicology, 10, 567, 10.3109/17435390.2015.1100761 Song, 2015, Nanocomposite hydrogels and their applications in drug delivery and tissue engineering, J. Biomed. Nanotechnol., 11, 40, 10.1166/jbn.2015.1962 Song, 2016, Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT, Drug Des. Devel. Ther., 10, 2701, 10.2147/DDDT.S113804 Song, 2016, Synthesis of mesoporous-silica-coated Gd2O3:Eu@silica particles as cell imaging and drug delivery agents, Dalton Trans., 45, 7443, 10.1039/C5DT04908C Starsich, 2016, Silica-coated nonstoichiometric nano Zn-ferrites for magnetic resonance imaging and hyperthermia treatment, Adv. Healthc. Mater, 10.1002/adhm.201600725 Stöber, 1968, Controlled growth of monodisperse silica spheres in the micron size range, J. Colloid Interface Sci., 26, 62, 10.1016/0021-9797(68)90272-5 Stoccoro, 2013, Epigenetic effects of nano-sized materials, Toxicology, 313, 3, 10.1016/j.tox.2012.12.002 Summerlin, 2016, Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol, Colloids Surf. B Biointerfaces, 144, 1, 10.1016/j.colsurfb.2016.03.076 Sun, 2016, Bone-targeted mesoporous silica nanocarrier anchored by zoledronate for cancer bone metastasis, Langmuir, 32, 9237, 10.1021/acs.langmuir.6b02228 Tadayon, 2015, Delivery of tissue plasminogen activator and streptokinase magnetic nanoparticles to target vascular diseases, Int. J. Pharm., 495, 428, 10.1016/j.ijpharm.2015.09.008 Tamanna, 2015, Controlling antibiotic release from mesoporous silica nano drug carriers via self-assembled polyelectrolyte coating, J. Mater. Sci. Mater. Med., 26, 117, 10.1007/s10856-015-5444-0 Tang, 2011, Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery, Int. J. Pharm., 421, 388, 10.1016/j.ijpharm.2011.10.013 Tan, 2014, Drug encapsulation and release by mesoporous silica nanoparticles: the effect of surface functional groups, Chem. – Eur. J., 20, 11276, 10.1002/chem.201403551 Tan, 2011, 5.14-Microemulsion preparative methods (Overview) A2-Andrews, David L, 399 Tao, 2014, Magnetic mesoporous silica nanoparticles for potential delivery of chemotherapeutic drugs and hyperthermia, Dalton Trans., 43, 15482, 10.1039/C4DT01984A Tao, 2016, Anti-CD155 and anti-CD112 monoclonal antibodies conjugated to a fluorescent mesoporous silica nanosensor encapsulating rhodamine 6G and fluorescein for sensitive detection of liver cancer cells, Analyst, 141, 4933, 10.1039/C5AN01908G Tian, 2014, Fates of Fe3O4 and Fe3O4@SiO2 nanoparticles in human mesenchymal stem cells assessed by synchrotron radiation-based techniques, Biomaterials, 35, 6412, 10.1016/j.biomaterials.2014.04.052 Toda, 2016, Amorphous nanosilica particles block induction of oral tolerance in mice, J. Immunotoxicol., 13, 723, 10.3109/1547691X.2016.1171266 Tolbert, 2016, New hybrid organic/inorganic polysilsesquioxane–silica particles as sunscreens, ACS Appl. Mater. Interfaces, 8, 3160, 10.1021/acsami.5b10472 Tseng, 2016, A versatile theranostic delivery platform integrating magnetic resonance imaging/computed tomography, ph/cis-diol controlled release, and targeted therapy, ACS Nano, 10, 5809, 10.1021/acsnano.5b08130 Tukappa, 2016, Polyglutamic acid-gated mesoporous silica nanoparticles for enzyme-controlled drug delivery, Langmuir, 32, 8507, 10.1021/acs.langmuir.6b01715 Ugazio, 2016, Thermoresponsive mesoporous silica nanoparticles as a carrier for skin delivery of quercetin, Int. J. Pharm., 511, 446, 10.1016/j.ijpharm.2016.07.024 van der Zande, 2014, Sub-chronic toxicity study in rats orally exposed to nanostructured silica, Part. Fibre Toxicol., 11, 8, 10.1186/1743-8977-11-8 van Rijt, 2015, Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors, ACS Nano, 9, 2377, 10.1021/nn5070343 Veeranarayanan, 2012, Synthesis and application of luminescent single CdS quantum dot encapsulated silica nanoparticles directed for precision optical bioimaging, Int. J. Nanomedicine, 7, 3769 Velikova, 2016, Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of ε-poly-L-lysine capped mesoporous silica-based nanoparticles, Nanomedicine Nanotechnol. Biol. Med. Vogt, 2006, 40 nm, but not 750 or 1,500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin, J. Invest. Dermatol, 126, 1316, 10.1038/sj.jid.5700226 Wang, 2014, Fabrication of single-hole glutathione-responsive degradable hollow silica nanoparticles for drug delivery, ACS Appl. Mater. Interfaces, 6, 12600, 10.1021/am502585x Wang, 2016, Combined cancer therapy with hyaluronan-decorated fullerene-silica multifunctional nanoparticles to target cancer stem-like cells, Biomaterials, 97, 62, 10.1016/j.biomaterials.2016.04.030 Wang, 2016, High sensitivity of gold nanoparticles co-doped with Gd2O3 mesoporous silica nanocomposite to nasopharyngeal carcinoma cells, Sci. Rep., 6, 34367, 10.1038/srep34367 Wang, 2011, Two-phase synthesis of monodisperse silica nanospheres with amines or ammonia catalyst and their controlled self-assembly, ACS Appl. Mater. Interfaces, 3, 1538, 10.1021/am200104m Wang, 2016, Rational design of multifunctional dendritic mesoporous silica nanoparticles to load curcumin and enhance efficacy for breast cancer therapy, ACS Appl. Mater. Interfaces, 8, 26511, 10.1021/acsami.6b08400 Wang, 2015, Specific aptamer-conjugated mesoporous silica–carbon nanoparticles for HER2-targeted chemo-photothermal combined therapy, Acta Biomater., 16, 196, 10.1016/j.actbio.2015.01.002 Wang, 2016, Charge-Reversal aptes-modified mesoporous silica nanoparticles with high drug loading and release controllability, ACS Appl. Mater. Interfaces, 8, 17166, 10.1021/acsami.6b05370 Wang, 2014, Synthesis of core–shell graphitic carbon@silica nanospheres with dual-ordered mesopores for cancer-targeted photothermochemotherapy, ACS Nano, 8, 7870, 10.1021/nn5027214 Wang, 2017, Multiple imaging and excellent anticancer efficiency of an upconverting nanocarrier mediated by single near infrared light, Nanoscale, 9, 4759, 10.1039/C6NR09030C Wang, 2015, Mesoporous silica nanoparticles in drug delivery and biomedical applications, Nanomedicine Nanotechnol. Biol. Med., 11, 313, 10.1016/j.nano.2014.09.014 Wang, 2016, Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells, Int. J. Nanomedicine, 11, 6485, 10.2147/IJN.S117184 Wani, 2012, Surface functionalization of mesoporous silica nanoparticles controls loading and release behavior of mitoxantrone, Pharm. Res., 29, 2407, 10.1007/s11095-012-0766-9 Ward, 2016, Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model, Am. J. Surg., 212, 1140, 10.1016/j.amjsurg.2016.09.013 Wills, 2016, Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™), Part. Fibre Toxicol., 13, 50, 10.1186/s12989-016-0161-5 Winkler, 2016, Critical review of the safety assessment of nano-structured silica additives in food, J. Nanobiotechnology, 14, 44, 10.1186/s12951-016-0189-6 Wu, 2017, Synthesis and characterization of mesoporous magnetic nanocomposites wrapped with chitosan gatekeepers for pH-sensitive controlled release of doxorubicin, Mater. Sci. Eng. C, 70, 132 Wu, 2013, Synthesis of mesoporous silica nanoparticles, Chem. Soc. Rev., 42, 3862, 10.1039/c3cs35405a Wu, 2012, Nanotechnology in cosmetics: A review, Cosmet. Toilet, 6, 266 Wu, 2014, Visible-light-excited and europium-emissive nanoparticles for highly-luminescent bioimaging in vivo, Biomaterials, 35, 5830, 10.1016/j.biomaterials.2014.03.080 Wu, 2012, A new type of silica-coated Gd 2 (CO 3 ) 3:Tb nanoparticle as a bifunctional agent for magnetic resonance imaging and fluorescent imaging, Nanotechnology, 23, 205103, 10.1088/0957-4484/23/20/205103 Xie, 2010, Nanoparticle-based theranostic agents, Dev. Theranostic Agents Co-Deliv. Ther. Imaging Agents, 62, 1064 Xie, 2014, Negative-charge-functionalized mesoporous silica nanoparticles as drug vehicles targeting hepatocellular carcinoma, Int. J. Pharm., 474, 223 Xing, 2012, Coordination polymer coated mesoporous silica nanoparticles for ph-responsive drug release, Adv. Mater, 24, 6433, 10.1002/adma.201201742 Xiong, 2015, Cancer-cell-specific nuclear-targeted drug delivery by dual-ligand-modified mesoporous silica nanoparticles, Small, 11, 5919, 10.1002/smll.201501056 Xu, 2015, miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells, Sci. Rep., 5 Xu, 2015, Glutathione- and pH-responsive nonporous silica prodrug nanoparticles for controlled release and cancer therapy, Nanoscale, 7, 5859, 10.1039/C5NR00297D Yamaguchi, 2016, Dual-labeled near-infrared/99mTc imaging probes using PAMAM-coated silica nanoparticles for the imaging of HER2-expressing cancer cells, Int. J. Mol. Sci., 17, 10.3390/ijms17071086 Yamauchi, 1989, Surface characterization of ultramicro spherical particles of silica prepared by w/o microemulsion method, Int. Symp. Adsorpt., 37, 71 Yang, 2016, Reversing cancer multidrug resistance in xenograft models via orchestrating multiple actions of functional mesoporous silica nanoparticles, ACS Appl. Mater. Interfaces, 8, 22431, 10.1021/acsami.6b04885 Yang, 2017, Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayer-modified magnetic mesoporous silica nanocomposites, Biomater. Sci., 10.1039/C7BM00043J Yang, 2017, Altered microRNA expression profiles in lung damage induced by nanosized SiO 2, Bioengineered, 8, 45, 10.1080/21655979.2016.1227578 Yang, 2010, SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells, Part. Fibre Toxicol., 7, 1, 10.1186/1743-8977-7-1 Yang, 2016, Advances in silica based nanoparticles for targeted cancer therapy, Nanomedicine Nanotechnol. Biol. Med., 12, 317, 10.1016/j.nano.2015.10.018 Yao, 2006, FloDots: luminescent nanoparticles, Anal. Bioanal. Chem., 385, 518, 10.1007/s00216-006-0452-z Yao, 2016 Yoshida, 2014, Intestinal absorption and biological effects of orally administered amorphous silica particles, Nanoscale Res. Lett., 9, 532, 10.1186/1556-276X-9-532 Yuan, 2013, Mechanistic study of the covalent loading of paclitaxel via disulfide linkers for controlled drug release, Langmuir, 29, 734, 10.1021/la304324r Yu, 2009, Toxicity of amorphous silica nanoparticles in mouse keratinocytes, J. Nanoparticle Res., 11, 15, 10.1007/s11051-008-9417-9 Yu, 2013, Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells, Nanoscale, 5, 178, 10.1039/C2NR32145A Yu, 2013, Magnetic and pH-sensitive nanoparticles for antitumor drug delivery, Colloids Surf. B Biointerfaces, 103, 15, 10.1016/j.colsurfb.2012.10.041 Zaccariello, 2017, Formation and controlled growth of bismuth titanate phases into mesoporous silica nanoparticles: an efficient self-sealing nanosystem for UV filtering in cosmetic formulation, ACS Appl. Mater. Interfaces, 9, 1913, 10.1021/acsami.6b13252 Zeng, 2016, Cancer diagnosis and imaging-guided photothermal therapy using a dual-modality nanoparticle, ACS Appl. Mater. Interfaces, 8, 29232, 10.1021/acsami.6b06883 Zhang, 2014, Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo, J. Control. Release, 192, 192, 10.1016/j.jconrel.2014.06.037 Zhang, 2015, An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates, Nanoscale, 7, 12614, 10.1039/C5NR02767E Zhang, 2016, A hyaluronidase responsive nanoparticle-based drug delivery system for targeting colon cancer cells, Cancer Res., 10.1158/0008-5472.CAN-16-1681 Zhang, 2016, Co-Delivery of Cisplatin prodrug and chlorin e6 by mesoporous silica nanoparticles for chemo-photodynamic combination therapy to combat drug resistance, ACS Appl. Mater. Interfaces, 8, 13332, 10.1021/acsami.6b03881 Zhang, 2016, The Serum-resistant transfection evaluation and long-term stability of gene delivery dry powder based on mesoporous silica nanoparticles and polyethyleneimine by freezing-drying, AAPS Pharm. Sci. Tech., 1, 10.1208/s12249-016-0486-2 Zhang, 2015, Polymer-coated hollow mesoporous silica nanoparticles for triple-responsive drug delivery, ACS Appl. Mater. Interfaces, 7, 18179, 10.1021/acsami.5b05893 Zhang, 2016, Polymeric prodrug grafted hollow mesoporous silica nanoparticles encapsulating near-infrared absorbing dye for potent combined photothermal-chemotherapy, ACS Appl. Mater. Interfaces, 8, 6869, 10.1021/acsami.6b00376 Zhang, 2015, DNA-hybrid-gated photothermal mesoporous silica nanoparticles for nir-responsive and aptamer-targeted drug delivery, ACS Appl. Mater. Interfaces, 7, 20696, 10.1021/acsami.5b05522 Zhao, 1998, Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores, Science, 279, 548, 10.1126/science.279.5350.548 Zhao, 2015, Dual-stimuli responsive hyaluronic acid-conjugated mesoporous silica for targeted delivery to CD44-overexpressing cancer cells, Acta Biomater., 23, 147, 10.1016/j.actbio.2015.05.010 Zhao, 2017, Fluorescence and drug loading properties of ZnSe:Mn/ZnS-Paclitaxel/SiO2 nanocapsules templated by F127 micelles, J. Colloid Interface Sci., 490, 436, 10.1016/j.jcis.2016.11.079 Zhao, 2013, Preparation, characterization, and evaluation in vivo of Ins-SiO2-HP55 (insulin-loaded silica coating HP55) for oral delivery of insulin, Position Pap. Comment. More Eff. Adv. Drug Deliv. Syst., 454, 278 Zhao, 2015, A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug, Angew. Chem. Int., 54, 919, 10.1002/anie.201408510 Zheng, 2015, Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs, Dalton Trans., 44, 20186, 10.1039/C5DT03700J Zheng, 2015, Organosilane and Polyethylene glycol functionalized magnetic mesoporous silica nanoparticles as carriers for cpg immunotherapy in vitro and in vivo, PLoS One, 10, e0140265, 10.1371/journal.pone.0140265 Zheng, 2013, pH-sensitive poly(glutamic acid) grafted mesoporous silica nanoparticles for drug delivery, Int. J. Pharm., 450, 296, 10.1016/j.ijpharm.2013.04.014 Zheng, 2014, Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release, Int. J. Pharm., 463, 22, 10.1016/j.ijpharm.2013.12.045 Zhu, 2016, pH and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres, J. Colloid Interface Sci., 480, 39, 10.1016/j.jcis.2016.06.043 Zou, 2016, DNA Hypermethylation of CREB3L1 and Bcl-2 associated with the mitochondrial-mediated apoptosis via PI3K/Akt pathway in human BEAS-2B cells exposure to silica nanoparticles, PLoS One, 11, e0158475, 10.1371/journal.pone.0158475 Zou, 2013, Natural gelatin capped mesoporous silica nanoparticles for intracellular acid-triggered drug delivery, Langmuir, 29, 12804, 10.1021/la4022646 Zou, 2015, Programmed packaging of mesoporous silica nanocarriers for matrix metalloprotease 2-triggered tumor targeting and release, Biomaterials, 58, 35, 10.1016/j.biomaterials.2015.04.034