Nanocurcumin accords protection against acute hypobaric hypoxia induced lung injury in rats

Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP (2013) Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ 346:f1378 Akhtar F, Rizvi MMA, Kar SK (2012) Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice. Biotechnol Adv 30:310–320. doi:10.1016/j.biotechadv.2011.05.009 Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4:807–818. doi:10.1021/mp700113r Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB (2008) Biological activities of curcumin and its analogues (congeners) made by man and mother nature. Biochem Pharmacol 76:1590–1611. doi:10.1016/j.bcp.2008.08.008 Araneda OF, Tuesta M (2012) Lung oxidative damage by hypoxia. Oxidative Med Cell Longev 2012:1–18. doi:10.1155/2012/856918 Azzam ZS, Dumasius V, Saldias FJ, Adir Y, Sznajder JI, Factor P (2002) Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure. Circulation 105:497–501. doi:10.1161/hc0402.102848 Bärtsch P, Swenson ER (2013) Clinical practice: acute high-altitude illnesses. N Engl J Med 368:2294–2302. doi:10.1056/NEJMcp1214870 Berg JT (2004) Ginkgo biloba Extract prevents high altitude pulmonary edema in rats. High Alt Med Biol 5:429–434. doi:10.1089/ham.2004.5.429 Burtscher M, Pachinger O, Ehrenbourg I, Mitterbauer G, Faulhaber M, Pühringer R, Tkatchouk E (2004) Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease. Int J Cardiol 96:247–254. doi:10.1016/j.ijcard.2003.07.021 Cathcart R, Schwiers E, Ames BN (1983) Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal Biochem 134:111–116. doi:10.1016/0003-2697(83)90270-1 Chang M-Y, Parker E, El Nahas M, Haylor JL, Ong ACM (2007) Endothelin B receptor blockade accelerates disease progression in a murine model of autosomal dominant polycystic kidney disease. J Am Soc Nephrol 18:560–569. doi:10.1681/ASN.2006090994 Crosbie PAJ, Crosbie EJ, Dea MA, Walker M, Harrison R, Pernemalm M, Shah R, Joseph L, Booton R, Pierce A, Whetton AD (2016) ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing. BMJ Open Respir Res. doi:10.1136/bmjresp-2015-000114 Dumitrascu R, Weissmann N, Ghofrani HA, Dony E, Beuerlein K, Schmidt H, Stasch J, Gnoth MJ, Seeger W, Schermuly RT, Dumitrascu R, Weissmann N, Ghofrani HA (2006) Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling. Circulation. doi:10.1161/CIRCULATIONAHA.105.581405 Dumitrascu R, Weissmann N, Ghofrani HA, Dony E, Beuerlein K, Schmidt H, Stasch J-P, Gnoth MJ, Seeger W, Grimminger F, Schermuly RT (2006) Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling. Circulation 113:286–295. doi:10.1161/CIRCULATIONAHA.105.581405 Fagan KA, Mcmurtry IF, Rodman DM (2001) Role of endothelin-1 in lung disease. Respir Res 2:90–101 Flora G, Gupta D, Tiwari A (2013) Nanocurcumin: a promising therapeutic advancement over native curcumin. Crit Rev Ther Drug Carrier Syst 30:331–368. doi:10.1615/CritRevTherDrugCarrierSyst.2013007236 Fraccarollo D, Hu K, Galuppo P, Gaudron P, Ertl G (1997) Chronic endothelin receptor blockade attenuates progressive ventricular dilation and improves cardiac function in rats with myocardial infarction: possible involvement of myocardial endothelin system in ventricular remodeling. Circulation 96:3963–3973. doi:10.1161/01.CIR.96.11.3963 Giordano FJ (2005) Oxygen , oxidative stress , hypoxia , and heart failure. J clinincal Investig 115:500–5008. doi:10.1172/JCI200524408.500 Goerre S, Wenk M, Bärtsch P, Lüscher TF, Niroomand F, Hohenhaus E, Oelz O, Reinhart WH (1995) Endothelin-1 in pulmonary hypertension associated with high-altitude exposure. Circulation. doi:10.1161/01.CIR.91.2.359 Gonçalves-De-Albuquerque CF, Silva AR, Burth P, De Moraes IMM, Oliveira FMDJ, Younes-Ibrahim M, Dos Santos MDCB, D’Ávila H, Bozza PT, Faria Neto HCDC, De Castro Faria MV (2012) Oleic acid induces lung injury in mice through activation of the ERK pathway. Mediat Inflamm. doi:10.1155/2012/956509 Gutteridge JMC (1995) Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 41:1819–1828 Hackett PH, Roach RC, Hartig GS, Greene ER, Levine BD (1992) The effect of vasodilators on pulmonary hemodynamics in high altitude pulmonary edema: a comparison. Int J Sports Med 13(Suppl 1):S68–S71. doi:10.1055/s-2007-1024599 Hissin PJ, Hilf R (1976) A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214–226. doi:10.1016/0003-2697(76)90326-2 Hultgren HN (1996) High-altitude pulmonary edema: current concepts. Annu Rev Med 47:267–284. doi:10.1146/annurev.med.47.1.267 Ivy D, McMurtry IF, Yanagisawa M, Gariepy CE, Le Cras TD, Gebb SA, Morris KG, Wiseman RC, Abman SH (2001) Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 280:L1040–L1048 Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG (2000) Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Am J Physiol Lung Cell Mol Physiol 22:657–664 Kar SK, Akhtar F, Ray G PA (2010) Curcumin nanoparticles and methods of producing the same. Pat WO 2010/01 224 A2 1–80 Lee J, Li Y, Chen H, Lin R, Huang S, Chen H, Kuan P, Liao M, Chen C, Kuan Y (2010) Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils. Acta Pharmacol Sin 31:831–838. doi:10.1038/aps.2010.62 Lee SY, Li MH, Shi LS, Chu H, Ho CW, Chang TC (2013) Rhodiola crenulata extract alleviates hypoxic pulmonary edema in rats. Evidence-based Complement Altern Med 2013:1–9. doi:10.1155/2013/718739 LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275. doi:10.1007/s10982-008-9035-9 Maggiorini M, Leon-Velarde F (2003) High-altitude pulmonary hypertension: a pathophysiological entity to different diseases. Eur Respir J 22:1019–1025. doi:10.1183/09031936.03.00052403 Markou T, Chambers DJ (2014) Lung injury after simulated cardiopulmonary bypass in an isolated perfused rat lung preparation: role of mitogen-activated protein kinase/Akt signaling and the effects of theophylline. J Thorac Cardiovasc Surg 148:2335–2344. doi:10.1016/j.jtcvs.2014.04.037 Modesti PA, Vanni S, Morabito M, Modesti A, Gamberi T, Sofi F, Savia G, Mancia G, Franco G (2006) Role of endothelin-1 in exposure to high altitude. Circulation 114:1410–1416. doi:10.1161/CIRCULATIONAHA.105.605527 Modesti PA, Vanni S, Morabito M, Modesti A, Marchetta M, Gamberi T, Sofi F, Savia G, Mancia G, Gensini GF, Parati G (2006) Role of endothelin-1 in exposure to high altitude: acute mountain sickness and endothelin-1 (ACME-1) study. Circulation 114:1410–1416. doi:10.1161/CIRCULATIONAHA.105.605527 Nakanishi K, Tajima F, Nakata Y, Osada H, Tachibana S, Kawai T, Torikata C, Suga T, Takishima K, Aurues T, Ikeda T (1999) Expression of endothelin-1 in rats developing hypobaric hypoxia-induced pulmonary hypertension. Lab Investig 79:1347–1357 Nehra S, Bhardwaj V, Ganju L, Saraswat D (2015) Nanocurcumin prevents hypoxia induced stress in primary human ventricular cardiomyocytes by maintaining mitochondrial homeostasis. PLoS One 10:e0139121. doi:10.1371/journal.pone.0139121 Nehra S, Bhardwaj V, Kalra N, Ganju L, Bansal A, Saxena S, Saraswat D (2015) Nanocurcumin protects cardiomyoblasts H9c2 from hypoxia-induced hypertrophy and apoptosis by improving oxidative balance. J Physiol Biochem 71:239–251. doi:10.1007/s13105-015-0405-0 Nehra S, Bhardwaj V, Saraswat D (2014) Amlodipine protects rat ventricular cardiomyoblast H9c2 from hypoxia-induced apoptosis and restores oxidative balance by Akt-1–dependent manner. J Cardiovasc Pharmacol 64:375–384 Oelz O, Maggiorini M, Ritter M, Noti C, Waber U, Vock P, Bärtsch P (1992) Prevention and treatment of high altitude pulmonary edema by a calcium channel blocker. Int J Sports Med. doi:10.1055/s-2007-1024598 Physiol AJ, Cell L, Physiol M, Ali MH, Schlidt SA, Chandel NS, Hynes KL, Schumacker PT, Gewertz BL, Ali MIRH, Schlidt SA, Chandel NS, Hynes KL, Schumacker PT, Gewertz BL, Mir H, Schlidt SA, Chandel NS, Hynes KL, Schumacker PT, Bruce L (2013) Endothelial permeability and IL-6 production during hypoxia : role of ROS in signal transduction endothelial permeability and IL-6 production during hypoxia : role of ROS in signal transduction Rassler B, Marx G, Reissig C, Rohling MA, Tannapfel A, Wenger RH, Zimmer H (2007) Time course of hypoxia-induced lung injury in rats. Respir Physiol Neurobiol 159:45–54. doi:10.1016/j.resp.2007.05.008 Reddy NM, Potteti HR, Vegiraju S, Chen H-J, Tamatam CM, Reddy SP (2015) PI3K-AKT signaling via Nrf2 protects against hyperoxia-induced acute lung injury, but promotes inflammation post-injury independent of Nrf2 in mice. PLoS One 10:e0129676. doi:10.1371/journal.pone.0129676 Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL (2005) A potential role of the curry spice curcumin in Alzheimer’s disease. Curr Alzheimer Res 2:131–136. doi:10.2174/1567205053585882 Sartori C, Vollenweider L, Löffler BM, Delabays A, Nicod P, Bärtsch P, Scherrer U (1999) Exaggerated endothelin release in high-altitude pulmonary edema. Circulation 99:2665–2668. doi:10.1161/01.CIR.99.20.2665 Scherrer U, Rexhaj E, Jayet P, Allemann Y, Sartori C (2010) New insights in the pathogenesis of high-altitude pulmonary edema. Prog Cardiovasc Dis 52:485–492. doi:10.1016/j.pcad.2010.02.004 Semenza GL (1991) HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 4:1474–1480. doi:10.2528/pier13111003 Shehzad A, Ul-Islam M, Wahid F, Lee YS (2014) Multifunctional polymeric nanocurcumin for cancer therapy. J Nanosci Nanotechnol 14:803–814 Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PSSR (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64:353–356. doi:10.1055/s-2006-957450 Shukla D, Saxena S, Purushothaman J, Shrivastava K, Singh M, Shukla S, Malhotra VK, Mustoori S, Bansal A (2011) Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat. Eur J Pharmacol 656:101–109. doi:10.1016/j.ejphar.2011.01.038 Sieck GC (2002) Lung edema clearance: 20 years of progress invited review: lung edema clearance: role of Na+ -K+ -ATPase. J Appl Physiol 89:1253–1254. doi:10.1152/japplphysiol.00017.2004 Steizner TJ, O’Brien RF, Sato K, Weil JV (1988) Hypoxia-induced increases in pulmonary transvascular protein escape in rats. Modulation by glucocorticoids J Clin Invest 82:1840–1847. doi:10.1172/JCI113800 Stenmark KR, Fagan KA, Frid MG (2006) Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 99:675–691. doi:10.1161/01.RES.0000243584.45145.3f Stream JO, Grissom CK (2008) Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment. Wilderness Environ Med 19:293–303. doi:10.1580/07-WEME-REV-173.1 Swenson ER (2013) Hypoxic pulmonary vasoconstriction. High Alt Med Biol 14:101–110. doi:10.1089/ham.2013.1010 Sylvester JT, Shimoda LA, Aaronson PI, Ward JPT (2012) Hypoxic pulmonary vasoconstriction. Physiol Rev 92:367–520. doi:10.1152/physrev.00041.2010 Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA (1997) Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med 156:438–444. doi:10.1164/ajrccm.156.2.9609141 Tilton RG, Munsch CL, Sherwood SJ, Chen SJ, Chen YF, Wu C, Block N, Dixon RA, Brock TA (2000) Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(a) receptor antagonist. Pulm Pharmacol Ther 13:87–97. doi:10.1006/pupt.2000.0237 Utley HG, Bernheim F, Hochstein P (1967) Effect of sulfhydryl reagents on peroxidation in microsomes. Arch Biochem Biophys 118:29–32. doi:10.1016/0003-9861(67)90273-1 Wang J, Oldner A, Winskog C, Edston E, Walther SM (2006) Effects of endothelin receptor antagonism on acute lung injury induced by chlorine gas. Crit Care Med 34:1731–1737. doi:10.1097/01.CCM.0000218815.46611.63 Whayne TF (2013) Cardiovascular medicine at high altitude. Angiology. doi:10.1177/0003319713497086 Xi L, Serebrovskaya TV (2012) Intermittent hypoxia and human diseases. doi:10.1007/978-1-4471-2906-6 Xu X-Q, Jing Z-C (2009) High-altitude pulmonary hypertension. Eur Respir Rev 18:13–17. doi:10.1183/09059180.00011104