NVP-BEZ235, a dual PI3K/mTOR inhibitor, induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype

Seung Woo Hong1, Ji Sun Shin1, Jung Hwan Moon1, Ye Seul Kim1, Jooyoung Lee1, Eun Kyoung Choi1, Seung Hee Ha1, Dong Hoon Lee1, Ha Na Chung1, Jeong Eun Kim1, Kyu Pyo Kim2, Yong Sang Hong1, Jae‐Lyun Lee1, Wang Jae Lee3, Eun Kyung Choi1, Jung Shin Lee1, Dong Hoon Jin2, Tae Won Kim1
1Innovative Cancer Research, Asan Institute for Life Science, University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-gil, Songpa-gu, Seoul, 138-736, Republic of Korea
2Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-gil, Songpa-gu, Seoul, 138-736, Republic of Korea
3Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea

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