NMR relaxation of water in hydrogel polymers: A model for tissue

Magnetic Resonance in Medicine - Tập 9 Số 3 - Trang 325-332 - 1989
John C. Gore1, Mark S. Brown2, Jianhui Zhong2, Karl F. Mueller3, William R. Good3
1Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, 06510
2Department of Diagnostic Radiology, Yale University School ofkledicine, New Haven, Connecticut 06510
3Ciba Geigy Corporation, Saw Mill River Road, Ardsley, New York 10502

Tóm tắt

AbstractThe NMR relaxation rates ofa class of hydrated polymers (hydrogels) have been investigated over a wide range of frequencies (0.01 to 60 MHz) and compositions. The gels comprise long chains of polytetramethylene oxide diol crosslinked by copolymers of dimethylacrylamide and methylmethacrylate. The longitudinal relaxation rate dispersion curves of these materials are very similar to those shown by human tissues and they can be altered in flexible fashion by changing the polymer content. By substitution of the water by deuterium oxide, the contribution of intermolecular cross‐relaxation effects has been shown to account for two‐thirds the total water relaxation rate. With their close similarity to tissue relaxation behavior, hydrogels of differing compositions are particularly well‐suited to MRI phantoms and test objects. © 1989 Academic press, Inc.

Từ khóa


Tài liệu tham khảo

H.Lee Ph. D. thesis University of Utah 1974.

Koenig S. H., 1987, NMR Spectroscopy of Cells and Organisms

J.Zhong J. C.Gore andI. M.Armitage Magn. Reson. Med. (in press).

Thông tin
Thông tin xuất bản

Magnetic Resonance in Medicine

Tập 9 Số 3

325-332

Thông tin tác giả