NCCN Guidelines® Insights: Uterine Neoplasms, Version 3.2021

Journal of the National Comprehensive Cancer Network : JNCCN - Tập 19 Số 8 - Trang 888-895 - 2021

Nadeem R. Abu‐Rustum¹, Catheryn M. Yashar², Kristin Bradley³, Susana M. Campos⁴, Junzo Chino⁵, Hye Sook Chon⁶, Christina Chu⁷, David E. Cohn⁸, Marta A. Crispens⁹, Shari Damast¹⁰, Elisabeth Diver¹¹, Christine M. Fisher¹², Peter J. Frederick¹³, David K. Gaffney¹⁴, Suzanne George⁴, Robert L. Giuntoli¹⁵, Ernest Han¹⁶, Brooke E. Howitt¹¹, Warner K. Huh¹⁷, Jayanthi Lea¹⁸, Andrea Mariani¹⁹, David G. Mutch²⁰, Larissa Nekhlyudov⁴, Mirna Podoll⁹, Steven W. Remmenga²¹, R. Kevin Reynolds²², Ritu Salani²³, Rachel Sisodia²⁴, Pamela T. Soliman²⁵, Edward J. Tanner²⁶, Stefanie Ueda²⁷, Renata R. Urban²⁸, Stephanie L. Wethington²⁹, Emily Wyse³⁰, Kristine Zanotti³¹, Nicole R. McMillian³², Angela D. Motter³²

¹1Memorial Sloan Kettering Cancer Center;

²2UC San Diego Moores Cancer Center;

³3University of Wisconsin Carbone Cancer Center;

⁴4Dana-Farber/Brigham and Women’s Cancer Center;

⁵5Duke Cancer Institute;

⁶6Moffitt Cancer Center;

⁷7Fox Chase Cancer Center;

⁸8The Ohio State University Comprehensive Cancer Center-James Cancer Hospital and Solove Research Institute;

⁹9Vanderbilt-Ingram Cancer Center;

¹⁰10Yale Cancer Center/Smilow Cancer Hospital;

¹¹11Stanford Cancer Institute;

¹²12University of Colorado Cancer Center;

¹³13Roswell Park Comprehensive Cancer Center;

¹⁴14Huntsman Cancer Institute at the University of Utah;

¹⁵15Abramson Cancer Center at the University of Pennsylvania;

¹⁶16City of Hope National Medical Center;

¹⁷17O'Neal Comprehensive Cancer Center at UAB;

¹⁸18UT Southwestern Simmons Comprehensive Cancer Center;

¹⁹19Mayo Clinic Cancer Center;

²⁰20Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

²¹21Fred & Pamela Buffett Cancer Center;

²²22University of Michigan Rogel Cancer Center;

²³23UCLA Jonsson Comprehensive Cancer Center;

²⁴24Massachusetts General Hospital Cancer Center;

²⁵25The University of Texas MD Anderson Cancer Center;

²⁶26Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

²⁷27UCSF Helen Diller Family Comprehensive Cancer Center;

²⁸28Fred Hutchinson Cancer Research CenterSeattle Cancer Care Alliance;

²⁹29The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

³⁰30Patient Advocate;

³¹31Case Comprehensive Cancer CenterUniversity Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; and

³²32National Comprehensive Cancer Network.

Tóm tắt

The NCCN Guidelines for Uterine Neoplasms provide recommendations for diagnostic workup, clinical staging, and treatment options for patients with endometrial cancer or uterine sarcoma. These NCCN Guidelines Insights focus on the recent addition of molecular profiling information to aid in accurate diagnosis, classification, and treatment of uterine sarcomas.

Từ khóa

Tài liệu tham khảo

Parra-Herran, 2019, Uterine mesenchymal tumors: update on classification, staging, and molecular features, Surg Pathol Clin, 12, 363, 10.1016/j.path.2019.01.004

Kolin, 2020, SMARCA4-deficient uterine sarcoma and undifferentiated endometrial carcinoma are distinct clinicopathologic entities, Am J Surg Pathol, 44, 263, 10.1097/PAS.0000000000001375

de Kock, 2020, Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma, Mod Pathol, 33, 1207, 10.1038/s41379-019-0436-0

Huang, 2004, Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity, Am J Surg Pathol, 28, 224, 10.1097/00000478-200402000-00010

Yoon, 2019, Myxoid smooth muscle neoplasia of the uterus: comprehensive analysis by next-generation sequencing and nucleic acid hybridization, Mod Pathol, 32, 1688, 10.1038/s41379-019-0299-4

Hoang, 2017, Novel high-grade endometrial stromal sarcoma: a morphologic mimicker of myxoid leiomyosarcoma, Am J Surg Pathol, 41, 12, 10.1097/PAS.0000000000000721

Lewis, 2018, ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity, Mod Pathol, 31, 674, 10.1038/modpathol.2017.162

Lax, 2007, Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium, Pathology, 39, 46, 10.1080/00313020601146822

Chiang, 2019, PGR gene fusions identify a molecular subset of uterine epithelioid leiomyosarcoma with rhabdoid features, Am J Surg Pathol, 43, 810, 10.1097/PAS.0000000000001239

Lax, 2007, Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium, Pathology, 39, 46, 10.1080/00313020601146822

Goebel, 2020, Uterine tumor resembling ovarian sex cord tumor (UTROSCT): a morphologic and molecular study of 26 cases confirms recurrent NCOA1-3 rearrangement, Am J Surg Pathol, 44, 30, 10.1097/PAS.0000000000001348

Lee, 2012, The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor, Am J Surg Pathol, 36, 641, 10.1097/PAS.0b013e31824a7b1a

Binzer-Panchal, 2019, Integrated molecular analysis of undifferentiated uterine sarcomas reveals clinically relevant molecular subtypes, Clin Cancer Res, 25, 2155, 10.1158/1078-0432.CCR-18-2792

Tessier-Cloutier, 2021, SWI/SNF-deficiency defines highly aggressive undifferentiated endometrial carcinoma, J Pathol Clin Res, 7, 144, 10.1002/cjp2.188

Tropé, 2012, Diagnosis and treatment of sarcoma of the uterus. A review, Acta Oncol, 51, 694, 10.3109/0284186X.2012.689111

Dickson, 2019, Uterine tumor resembling ovarian sex cord tumor: a distinct entity characterized by recurrent NCOA2/3 gene fusions, Am J Surg Pathol, 43, 178, 10.1097/PAS.0000000000001153

Novetsky, 2013, Management of sarcomas of the uterus, Curr Opin Oncol, 25, 546, 10.1097/CCO.0b013e328363e0ef

Kolin, 2018, SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma, Mod Pathol, 31, 1442, 10.1038/s41379-018-0049-z

Yoon, 2019, Myxoid smooth muscle neoplasia of the uterus: comprehensive analysis by next-generation sequencing and nucleic acid hybridization, Mod Pathol, 32, 1688, 10.1038/s41379-019-0299-4

Lee, 2019, Clinicopathologic characterization of GREB1-rearranged uterine sarcomas with variable sex-cord differentiation, Am J Surg Pathol, 43, 928, 10.1097/PAS.0000000000001265

Moore, 2017, Uterine tumour resembling ovarian sex cord tumour: first report of a large series with follow-up, Histopathology, 71, 751, 10.1111/his.13296

Lee, 2019, Clinicopathologic characterization of GREB1-rearranged uterine sarcomas with variable sex-cord differentiation, Am J Surg Pathol, 43, 928, 10.1097/PAS.0000000000001265

Siegel, 2021, Cancer statistics, 2021, CA Cancer J Clin, 71, 7, 10.3322/caac.21654

D’Angelo, 2010, Uterine sarcomas: a review, Gynecol Oncol, 116, 131, 10.1016/j.ygyno.2009.09.023

Koontz, 2001, Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors, Proc Natl Acad Sci USA, 98, 6348, 10.1073/pnas.101132598

Pinto, 2018, Uterine rhabdomyosarcoma in adults, Hum Pathol, 74, 122, 10.1016/j.humpath.2018.01.007

Cotzia, 2019, Undifferentiated uterine sarcomas represent under-recognized high-grade endometrial stromal sarcomas, Am J Surg Pathol, 43, 662, 10.1097/PAS.0000000000001215

Li, 2013, Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature, Am J Surg Pathol, 37, 344, 10.1097/PAS.0b013e31826e0271

Selenica, 2021, Genomic profiling aids classification of diagnostically challenging uterine mesenchymal tumors with myomelanocytic differentiation, Am J Surg Pathol, 45, 77, 10.1097/PAS.0000000000001572

Leath, 2007, A multi-institutional review of outcomes of endometrial stromal sarcoma, Gynecol Oncol, 105, 630, 10.1016/j.ygyno.2007.01.031

Bennett, Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations, Mod Pathol

Zou, 2020, High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities, Mod Pathol, 33, 1861, 10.1038/s41379-020-0535-y

Köbel, 2018, Undifferentiated endometrial carcinomas show frequent loss of core switch/sucrose nonfermentable complex proteins, Am J Surg Pathol, 42, 76, 10.1097/PAS.0000000000000941

Parra-Herran, 2019, Uterine mesenchymal tumors: update on classification, staging, and molecular features, Surg Pathol Clin, 12, 363, 10.1016/j.path.2019.01.004

Cotzia, 2019, Undifferentiated uterine sarcomas represent under-recognized high-grade endometrial stromal sarcomas, Am J Surg Pathol, 43, 662, 10.1097/PAS.0000000000001215

Tropé, 2012, Diagnosis and treatment of sarcoma of the uterus. A review, Acta Oncol, 51, 694, 10.3109/0284186X.2012.689111

Leiner, 2020, The current landscape of rhabdomyosarcomas: an update, Virchows Arch, 476, 97, 10.1007/s00428-019-02676-9

de Kock, 2020, Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma, Mod Pathol, 33, 1207, 10.1038/s41379-019-0436-0

Leiner, 2020, The current landscape of rhabdomyosarcomas: an update, Virchows Arch, 476, 97, 10.1007/s00428-019-02676-9

Arias-Stella, 2019, Novel PLAG1 gene rearrangement distinguishes a subset of uterine myxoid leiomyosarcoma from other uterine myxoid mesenchymal tumors, Am J Surg Pathol, 43, 382, 10.1097/PAS.0000000000001196

Zou, 2020, High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities, Mod Pathol, 33, 1861, 10.1038/s41379-020-0535-y

Kurman, 2014, WHO Classification of Tumours of Female Reproductive Organs, Vol. 6

D’Angelo, 2010, Uterine sarcomas: a review, Gynecol Oncol, 116, 131, 10.1016/j.ygyno.2009.09.023

Pinto, 2018, Uterine rhabdomyosarcoma in adults, Hum Pathol, 74, 122, 10.1016/j.humpath.2018.01.007

Binzer-Panchal, 2019, Integrated molecular analysis of undifferentiated uterine sarcomas reveals clinically relevant molecular subtypes, Clin Cancer Res, 25, 2155, 10.1158/1078-0432.CCR-18-2792

Mariño-Enriquez, 2018, BCOR internal tandem duplication in high-grade uterine sarcomas, Am J Surg Pathol, 42, 335, 10.1097/PAS.0000000000000993

Koontz, 2001, Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors, Proc Natl Acad Sci USA, 98, 6348, 10.1073/pnas.101132598

Bennett, Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations, Mod Pathol

Moore, 2017, Uterine tumour resembling ovarian sex cord tumour: first report of a large series with follow-up, Histopathology, 71, 751, 10.1111/his.13296

Hoang, 2017, Novel high-grade endometrial stromal sarcoma: a morphologic mimicker of myxoid leiomyosarcoma, Am J Surg Pathol, 41, 12, 10.1097/PAS.0000000000000721

Lewis, 2018, ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity, Mod Pathol, 31, 674, 10.1038/modpathol.2017.162

Kolin, 2020, SMARCA4-deficient uterine sarcoma and undifferentiated endometrial carcinoma are distinct clinicopathologic entities, Am J Surg Pathol, 44, 263, 10.1097/PAS.0000000000001375

Köbel, 2018, Undifferentiated endometrial carcinomas show frequent loss of core switch/sucrose nonfermentable complex proteins, Am J Surg Pathol, 42, 76, 10.1097/PAS.0000000000000941

Amant, 2009, Clinical management of uterine sarcomas, Lancet Oncol, 10, 1188, 10.1016/S1470-2045(09)70226-8