Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination
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Inoue K, Ogawa H, Sonoda Y, Kimura T, Sakabe H, Oka Y, Miyake S, Tamaki H, Oji Y, Yamagami T: Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia. Blood. 1997, 89: 1405-1412.
Menssen HD, Renkl HJ, Rodeck U, Maurer J, Notter M, Schwartz S, Reinhardt R, Thiel E: Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia. 1995, 9: 1060-1067.
Miwa H, Beran M, Saunders GF: Expression of the Wilms' tumor gene (WT1) in human leukemias. Leukemia. 1992, 6: 405-409.
Nakatsuka S, Oji Y, Horiuchi T, Kanda T, Kitagawa M, Takeuchi T, Kawano K, Kuwae Y, Yamauchi A, Okumura M: Immunohistochemical detection of WT1 protein in a variety of cancer cells. Mod Pathol. 2006, 19: 804-814.
Sugiyama H: Cancer immunotherapy targeting WT1 protein. Int J Hematol. 2002, 76: 127-132. 10.1007/BF02982574.
Oka Y, Tsuboi A, Oji Y, Kawase I, Sugiyama H: WT1 peptide vaccine for the treatment of cancer. Curr Opin Immunol. 2008, 20: 211-220. 10.1016/j.coi.2008.04.009.
Rezvani K, Yong AS, Mielke S, Savani BN, Musse L, SUperata J, Jafapour B, Boss C, Barrett AJ: Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008, 111: 236-242. 10.1182/blood-2007-08-108241.
Keilholz U, Letsch A, Busse A, Asemissen AM, Bauer S, Blau IW, Hofmann WK, Uharek L, Thiel E, Scheibenbogen C: A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS. Blood. 2009, 113: 6541-6548. 10.1182/blood-2009-02-202598.
Gajewski TF, Meng Y, Harlin H: Immune suppression in the tumor microenvironment. J Immunother. 2006, 29: 233-240. 10.1097/01.cji.0000199193.29048.56.
Seliger B: Strategies of tumor immune evasion. BioDrugs. 2005, 19: 347-354. 10.2165/00063030-200519060-00002.
Kim R, Emi M, Tanabe K: Cancer immunoediting from immune surveillance to immune escape. Immunology. 2007, 121: 1-14. 10.1111/j.1365-2567.2007.02587.x.
Slingluff CL, Colella TA, Thompson L, Graham DD, Skipper JC, Caldwell J, Brinckerhoff L, Kittlesen DJ, Deacon DH, Oei C: Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens. Cancer Immunol Immunother. 2000, 48: 661-672. 10.1007/s002620050015.
Singh R, Paterson Y: Immunoediting sculpts tumor epitopes during immunotherapy. Cancer Res. 2007, 67: 1887-1892. 10.1158/0008-5472.CAN-06-3960.
Seifert U, Liermann H, Racanelli V, Halenius A, Wiese M, Wedemeyer H, Ruppert T, Rispeter K, Henklein P, Sijts A: Hepatitis C virus mutation affects proteasomal epitope processing. J Clin Invest. 2004, 114: 250-259.
Theobald M, Ruppert T, Kuckelkorn U, Hernandez J, Haussler A, Ferreira EA, Liewer U, Biggs J, Levine AJ, Huber C: The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope. J Exp Med. 1998, 188: 1017-1028. 10.1084/jem.188.6.1017.
Marincola FM, Jaffee EM, Hicklin DJ, Ferrone S: Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv Immunol. 2000, 74: 181-273. full_text.
Algarra I, Cabrera T, Garrido F: The HLA crossroad in tumor immunology. Hum Immunol. 2000, 61: 65-73. 10.1016/S0198-8859(99)00156-1.
Watson NF, Ramage JM, Madjd Z, Spendlove I, Ellis IO, Scholefield JH, Durrant LG: Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis. Int J Cancer. 2006, 118: 6-10. 10.1002/ijc.21303.
Seliger B, Atkins D, Bock M, Ritz U, Ferrone S, Huber C, Storkel S: Characterization of human lymphocyte antigen class I antigen-processing machinery defects in renal cell carcinoma lesions with special emphasis on transporter-associated with antigen-processing down-regulation. Clin Cancer Res. 2003, 9: 1721-1727.
Seliger B, Maeurer MJ, Ferrone S: Antigen-processing machinery breakdown and tumor growth. Immunol Today. 2000, 21: 455-464. 10.1016/S0167-5699(00)01692-3.
Garcia-Lora A, Martinez M, Algarra I, Gaforio JJ, Garrido F: MHC class I-deficient metastatic tumor variants immunoselected by T lymphocytes originate from the coordinated downregulation of APM components. Int J Cancer. 2003, 106: 521-527. 10.1002/ijc.11241.
Siehl JM, Thiel E, Heufelder K, Snarski E, Schwartz S, Mailander V, Keilholz U: Possible regulation of Wilms' tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias. Br J Haematol. 2003, 123: 235-242. 10.1046/j.1365-2141.2003.04622.x.
King-Underwood L, Pritchard-Jones K: Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood. 1998, 91: 2961-2968.
Summers K, Stevens J, Kakkas I, Smith M, Smith LL, Macdougall F, Cavenagh J, Bonnet D, Young BD, Lister TA, Fitzgibbon J: Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML. Leukemia. 2007, 21: 550-551. 10.1038/sj.leu.2404514. author reply 552