Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population

Wiley - Tập 3 Số 2 - Trang 132-142 - 2011
Mederic M. Mederic M., Jonathan T. Jonathan T., Jay Jay

Tóm tắt

Fluoroquinolone antibiotics are associated with a wide spectrum of musculoskeletal complications that involve not only tendon but also cartilage, bone, and muscle. Insights into the pathoetiology of fluoroquinolone toxicity on musculoskeletal tissues have been evolving over recent years. Although the pathoetiology is certainly multifactorial, alterations in cell signaling proteins and direct toxic effects on musculoskeletal tissues have been strongly implicated. Increasing age and concomitant systemic corticosteroid use appear to significantly increase the risk of adverse events. The purpose of this article is to review the musculoskeletal complications associated with use of fluoroquinolone antibiotics by adults; identify risk factors associated with fluoroquinolone toxicity; explore the possible pathoetiology of fluoroquinolone toxicity on tendon, cartilage, bone, and muscle; and offer recommendations regarding evaluation and treatment of fluoroquinolone‐associated musculoskeletal complications. In addition, this review will provide recommendations regarding fluoroquinolone use in athletes and return to play after fluoroquinolone exposure.

Tài liệu tham khảo

10.1191/0960327102ht305oa 10.1002/jor.1100180507 10.1016/j.cps.2005.05.004 10.1002/1529-0131(200106)45:3<235::AID-ART254>3.3.CO;2-Z 10.1345/aph.1K347 10.1016/j.amjmed.2004.09.015 Bailey R.R., 1983, Norfloxacin‐induced rheumatic disease, N Z Med J, 96, 590 10.1136/bmj.a816 Facts & Comparisons. Quinolones Facts & Comparisons. Fluoroquinolones 10.1177/107110079701800510 Corps AN Harrall RL Curry VA Fenwick SA Hazleman BL Riley GP. Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin‐1beta in human tendon‐derived cells. A potential mechanism of fluoroquinolone‐induced tendinopathy. Arthritis Rheum 200;46:3034‐3040. 10.1177/107110070302400204 10.1177/03635465000280031401 10.1152/ajpregu.00089.2008 10.1016/S0092-8674(02)00971-6 10.1007/s002040100243 10.1016/j.tox.2005.04.002 10.1016/S0945-053X(01)00128-7 10.1016/S0140-6736(02)11529-7 10.1124/jpet.103.057984 10.1080/10715760902736275 10.1081/DCT-120037504 10.1016/j.tox.2006.09.016 10.1128/AAC.01175-06 10.1023/A:1007435025616 10.1016/j.transproceed.2007.01.077 10.1016/j.amjopharm.2008.11.002 10.1179/joc.2007.19.6.688 10.1016/j.bjps.2006.08.005 10.3113/FAI.2007.1287 10.1053/j.jfas.2007.03.014 10.1056/NEJMicm061227 10.1007/s00228-007-0265-9 10.1111/j.1464-5491.2006.02003.x 10.1136/emj.2006.035832 10.2165/00002018-200629100-00006 Luthje P., 2005, Missed Achilles tendon rupture due to oral levofloxacin: surgical treatment and result, Arch Orthop Trauma Surg, 125, 124, 10.1007/s00402-004-0784-0 McKinley B.T., 2004, A 57‐year‐old male retired colonel with acute ankle swelling, Mil Med, 169, 254, 10.7205/MILMED.169.3.254 10.1080/00365540410019390 10.1016/j.jbspin.2003.10.016 10.1080/00365540310015863 Schindler C., 2003, Reoccurrence of levofloxacin‐induced tendinitis by phenoxymethylpenicillin therapy after 6 months: a rare complication of fluoroquinolone therapy?, Chemotherapy, 49, 90, 10.1159/000069776 Haddow L.J., 2003, Spontaneous Achilles tendon rupture in patients treated with levofloxacin, J Antimicrob Chemother, 51, 747, 10.1093/jac/dkg081 10.3122/jabfm.16.5.458 10.1086/375078 10.1007/s10067-003-0758-6 10.7547/87507315-93-4-333 10.1007/s00776-003-0761-4 10.1345/aph.1C505 La Red G., 2003, Bilateral Achilles tendinitis with spontaneous rupture induced by levofloxacin in a patient with systemic sclerosis, Clin Rheumatol, 22, 367, 10.1007/s10067-003-0732-3 Greene B.L., 2002, Physical therapist management of fluoroquinolone‐induced Achilles tendinopathy, Phys Ther, 82, 1224, 10.1093/ptj/82.12.1224 10.1136/bmj.324.7349.1306 10.1183/09031936.02.00257202 10.1097/00007611-200093050-00008 Schwald N., 1999, Suspected role of ofloxacin in a case of arthalgia, myalgia, and multiple tendinopathy, Rev Rheum Engl Ed, 66, 419 10.1097/00007611-199906000-00014 10.1016/S0140-6736(88)92489-0 Le Huec J.C., 1995, Epicondylitis after treatment with fluoroquinolone antibiotics, J Bone Joint Surg Br, 77, 293, 10.1302/0301-620X.77B2.7706350 Mouzopoulos G., 2005, Rupture of adductor longus tendon due to ciprofloxacin, Acta Orthop Belg, 71, 743 10.1111/j.1365-2125.2006.02631.x 10.1097/JSM.0b013e31814c3e69 10.1159/000149720 10.1016/j.ophtha.2009.06.027 10.1046/j.1365-2125.1999.00016.x Pierfitte C., 1996, Tendon disorders with fluoroquinolones, Therapie, 51, 419 10.1046/j.1365-2125.1996.03013.x 10.1001/archinte.163.15.1801 Belavic J.M., 2009, Fluoroquinolone‐induced tendinopathy, Nurse Pract, 34, 17, 10.1097/01.NPR.0000343751.83969.1b 10.1007/BF01713325 10.1128/AAC.41.11.2562 10.1097/BPO.0b013e3181982c4f Multhaupt H.A., 2001, Fluoroquinolone's effect on growth of human chondrocytes and chondrosarcomas. In vitro and in vivo correlation, J Bone Joint Surg Am, 83, 56, 10.2106/00004623-200100021-00012 10.1007/s002040050010 10.1354/vp.38-2-143 10.2106/00004623-200002000-00002 Perry A.C., 2003, Levofloxacin and trovafloxacin inhibition of experimental fracture‐healing, Clin Orthop Relat Res, 95, 10.1097/01.blo.0000087322.60612.14 10.1177/194589240501900413 Hernandez R., 2008, Clinical inquiries. Is there much risk in using fluoroquinolones in children?, J Fam Pract, 57, 539 Forsythe C.T., 2007, Do fluoroquinolones commonly cause arthropathy in children?, Can J Emerg Med, 9, 459, 10.1017/S1481803500015517 10.1097/00006454-199508000-00014 10.1542/peds.111.6.e714 10.1159/000239194 Chang H., 1996, Pefloxacin‐induced arthropathy in an adolescent with brain abscess, Scand J Infect Dis, 28, 641, 10.3109/00365549609037977 10.1086/313551 Guis S., 2001, Malignant hyperthermia susceptibility revealed by myalgia and rhabdomyolysis during fluoroquinolone treatment, J Rheumatol, 28, 1405 10.1002/art.10094 Kumar S., 2003, Steroid‐induced myopathy following a single oral dose of prednisolone, Neurol India, 51, 554 10.1002/mus.20915 10.1111/j.1365-2265.2009.03683.x Sawant R.D., 2009, Rhabdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin, Can J Clin Pharmacol, 16, e78 10.1093/ndt/gfl396 10.1007/s00228-003-0688-x 10.1345/aph.1E285 10.4103/0022-3859.41813 Roberts J.R., 2006, Serial sonographic evaluation of Achilles tendons in patients taking fluoroquinolone antibiotics, Hawaii Med J, 65, 112 Arnaud M.J., 2008, Update on the assessment of magnesium status, Br J Nutr, 99, S24, 10.1017/S000711450800682X Cohen J., A report of major improvement in a case of fluoroquinolone toxicity. MedicationSense E‐Newsletter Lavalle M., 2003, Medical committee report, USA Weightlifting Magazine, 22, 7