Multiresistant Salmonella enterica serovar 4,[5],12:i:- in Europe: a new pandemic strain?

Eurosurveillance - Tập 15 Số 22 - 2010
Katie L. Hopkins1, Miranda Kirchner2, Beatriz Guerra3, Sophie A. Granier4, Claudio Lucarelli5, M. Concepción Porrero6, A. Jakubczak7, E J Threlfall1, Dik Mevius8,9
1Health Protection Agency, Centre for Infections, London, United Kingdom
2Veterinary Laboratories Agency, Weybridge, United Kingdom
3Federal Institute for Risk Assessment, Berlin, Germany
4Agence Française de Sécurité Sanitaire des Aliments, Maisons-Alfort, France
5Istituto Superiore di Sanitá, Rome Italy
6Health Surveillance Centre (VISAVET), University Complutense, Madrid, Spain
7National Institute of Public Health, Warsaw, Poland
8Central Veterinary Institute of Wageningen, Lelystad, The Netherlands
9Faculty of Veterinary Medicine, Utrecht University, The Netherlands

Tóm tắt

A marked increase in the prevalence of S. enterica serovar 4,[5],12:i:- with resistance to ampicillin, streptomycin, sulphonamides and tetracyclines (R-type ASSuT) has been noted in food-borne infections and in pigs/pig meat in several European countries in the last ten years. One hundred and sixteen strains of S. enterica serovar 4,[5],12:i:- from humans, pigs and pig meat isolated in England and Wales, France, Germany, Italy, Poland, Spain and the Netherlands were further subtyped by phage typing, pulsed-field gel electrophoresis and multilocus variable number tandem repeat analysis to investigate the genetic relationship among strains. PCR was performed to identify the fljB flagellar gene and the genes encoding resistance to ampicillin, streptomycin, sulphonamides and tetracyclines. Class 1 and 2 integrase genes were also sought. Results indicate that genetically related serovar 4,[5],12:i:- strains of definitive phage types DT193 and DT120 with ampicillin, streptomycin, sulphonamide and tetracycline resistance encoded by blaTEM, strA-strB, sul2 and tet(B) have emerged in several European countries, with pigs the likely reservoir of infection. Control measures are urgently needed to reduce spread of infection to humans via the food chain and thereby prevent the possible pandemic spread of serovar 4,[5],12:i:- of R-type ASSuT as occurred with S. Typhimurium DT104 during the 1990s.

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Eurosurveillance

Tập 15 Số 22

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