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We thank D. Fink J. Andres R. Deans F. Barry S Bruder M. Thiede A. Moseley and J. Burns for discussion and review of the manuscript; M. Black and M. Earlington for cell isolation from marrow; and D. Sterchi D. Brown and J. Skwarek for histology. This work was supported by Osiris Therapeutics (www.osiristx.com) and in part by a research contract from the Defense Advanced Research Projects Agency.