Kháng đa thuốc trong tế bào ung thư: Tập trung vào một kế hoạch chiến lược khả thi để giải quyết tế bào carcinôm đại tràng

Life - Tập 12 Số 6 - Trang 811
Chenmala Karthika1, R. Sureshkumar1, Mehrukh Zehravi2, Rokeya Akter3, Faraat Ali4, Sarker Ramproshad5, Banani Mondal5, Milton Kumar Kundu6, Abhijit Dey7, Md. Habibur Rahman3, Angela Antonescu8, Simona Cavalu8
1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty 643001, India
2Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University, Alkharj 11942, Saudi Arabia
3Department of Global Medical Science, Wonju College of Medicine, Yonsei University, 24, Wonju 26426, Korea
4Department of Licensing and Enforcement, Laboratory Services, Botswana Medicines Regulatory Authority (BoMRA), Gaborone 999106, Botswana
5Department of Pharmacy, Ranada Prasad Shaha University, Narayanganj 1400, Bangladesh
6Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh
7Department of Life Sciences, Presidency University, Kolkata, 700073, India
8Faculty of Medicine and Pharmacy, University of Oradea, Pta 1 Decembrie 10, 410087 Oradea, Romania

Tóm tắt

Dù có nhiều phương pháp điều trị cho ung thư, tỷ lệ tử vong vẫn không giảm. Việc chẩn đoán ung thư ở giai đoạn thứ tư và kháng thuốc là những lý do chính dẫn đến thất bại trong điều trị và tỷ lệ sống sót thấp hơn. Trong bài báo tổng quan này, chúng tôi tóm tắt những cạm bẫy có thể gặp phải trong quá trình điều trị ung thư nói chung, chủ yếu bao gồm kháng đa thuốc, và đề xuất một giả thuyết đặc biệt cho ung thư đại tràng. Chúng tôi cũng đánh giá kháng đa thuốc trong ung thư nói chung và ung thư đại tràng nói riêng và giả thuyết một khái niệm dựa trên trị liệu kết hợp với 5-fluorouracil, curcumin và lipid để quản lý ung thư đại tràng có thể. Thêm vào đó, một cách tiếp cận giả thuyết, kết hợp một tác nhân tổng hợp và một tác nhân hóa trị liệu tự nhiên, để điều trị ung thư đại tràng cũng được thảo luận. Giả thuyết này có thể cải thiện việc quản lý ung thư đại tràng.

Từ khóa

#kháng đa thuốc #ung thư #ung thư đại tràng #phương pháp điều trị #kết hợp liệu pháp

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