Kháng đa thuốc trong tế bào ung thư: Tập trung vào một kế hoạch chiến lược khả thi để giải quyết tế bào carcinôm đại tràng
Tóm tắt
Dù có nhiều phương pháp điều trị cho ung thư, tỷ lệ tử vong vẫn không giảm. Việc chẩn đoán ung thư ở giai đoạn thứ tư và kháng thuốc là những lý do chính dẫn đến thất bại trong điều trị và tỷ lệ sống sót thấp hơn. Trong bài báo tổng quan này, chúng tôi tóm tắt những cạm bẫy có thể gặp phải trong quá trình điều trị ung thư nói chung, chủ yếu bao gồm kháng đa thuốc, và đề xuất một giả thuyết đặc biệt cho ung thư đại tràng. Chúng tôi cũng đánh giá kháng đa thuốc trong ung thư nói chung và ung thư đại tràng nói riêng và giả thuyết một khái niệm dựa trên trị liệu kết hợp với 5-fluorouracil, curcumin và lipid để quản lý ung thư đại tràng có thể. Thêm vào đó, một cách tiếp cận giả thuyết, kết hợp một tác nhân tổng hợp và một tác nhân hóa trị liệu tự nhiên, để điều trị ung thư đại tràng cũng được thảo luận. Giả thuyết này có thể cải thiện việc quản lý ung thư đại tràng.
Từ khóa
#kháng đa thuốc #ung thư #ung thư đại tràng #phương pháp điều trị #kết hợp liệu phápTài liệu tham khảo
Kim, 2019, Deep Learning-Based Survival Prediction of Oral Cancer Patients, Sci. Rep., 9, 6994, 10.1038/s41598-019-43372-7
García-Alfonso, P., Muñoz Martín, A.J., Ortega Morán, L., Soto Alsar, J., Torres Perez-Solero, G., Blanco Codesido, M., Calvo Ferrandiz, P.A., and Grasso Cicala, S. (2021). Oral Drugs in the Treatment of Metastatic Colorectal Cancer. Ther. Adv. Med. Oncol., 13.
Williamson, 2021, Metabolism and Pharmacokinetic Optimization Strategies in Drug Discovery, Drug Discovery and Development E-Book: Technology in Transition, Volume 134, 134
Jelski, 2020, Biochemical Markers of Colorectal Cancer–Present and Future, Cancer Manag. Res., 12, 4789, 10.2147/CMAR.S253369
Pilleron, 2019, Global Cancer Incidence in Older Adults, 2012 and 2035: A Population-based Study, Int. J. Cancer, 144, 49, 10.1002/ijc.31664
Sawicki, T., Ruszkowska, M., Danielewicz, A., Niedźwiedzka, E., Arłukowicz, T., and Przybyłowicz, K.E. (2021). A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis. Cancers, 13.
Asano, H., Fukano, H., Takagi, M., and Takayama, T. (Asian J. Surg., 2022). Risk Factors for the Recurrence of Stage II Perforated Colorectal Cancer: A Retrospective Observational Study, Asian J. Surg., in press.
Dong, 2020, Regulation of Cancer Cell Metabolism: Oncogenic MYC in the Driver’s Seat, Signal Transduct. Target. Ther., 5, 124, 10.1038/s41392-020-00235-2
Simon, 2021, Surface Properties of Collagen-Functionalized Aluminosilicate Particles Embedding Iron and Dysprosium Designed for Cancer Therapy, J. Mol. Struct., 1236, 130341, 10.1016/j.molstruc.2021.130341
Michaelis, 2019, Drug-Adapted Cancer Cell Lines as Preclinical Models of Acquired Resistance, Cancer Drug Resist., 2, 447
Aniogo, 2019, The Role of Photodynamic Therapy on Multidrug Resistant Breast Cancer, Cancer Cell Int., 19, 91, 10.1186/s12935-019-0815-0
Ishida, 2021, Targeted Therapy for Drug-Tolerant Persister Cells after Imatinib Treatment for Gastrointestinal Stromal Tumours, Br. J. Cancer, 125, 1511, 10.1038/s41416-021-01566-9
McMahon, 2019, Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia, Cancer Discov., 9, 1050, 10.1158/2159-8290.CD-18-1453
Sindhu, R.K., Najda, A., Kaur, P., Shah, M., Singh, H., Kaur, P., Cavalu, S., Jaroszuk-Sierocińska, M., and Rahman, M.H. (2021). Potentiality of Nanoenzymes for Cancer Treatment and Other Diseases: Current Status and Future Challenges. Materials, 14.
Islam, M.R., Islam, F., Nafady, M.H., Akter, M., Mitra, S., Das, R., Urmee, H., Shohag, S., Akter, A., and Chidambaram, K. (2022). Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint. Molecules, 27.
Parish, 2019, Steps to Address Anti-Microbial Drug Resistance in Today’s Drug Discovery, Expert Opin. Drug Discov., 14, 91, 10.1080/17460441.2019.1550481
Merz, 2021, Targeting KRAS: The Elephant in the Room of Epithelial Cancers, Front. Oncol., 11, 361, 10.3389/fonc.2021.638360
Patton, 2021, Zebrafish Disease Models in Drug Discovery: From Preclinical Modelling to Clinical Trials, Nat. Rev. Drug Discov., 20, 611, 10.1038/s41573-021-00210-8
Das, 2021, Pectin Based Multi-Particulate Carriers for Colon-Specific Delivery of Therapeutic Agents, Int. J. Pharm., 605, 120814, 10.1016/j.ijpharm.2021.120814
Cavalu, 2013, Microscopic and spectroscopic investigation of bioactive glasses for antibiotic controlled release, J. Mol. Struct., 1040, 47, 10.1016/j.molstruc.2013.02.016
Eliaa, 2020, Empagliflozin and Doxorubicin Synergistically Inhibit the Survival of Triple-Negative Breast Cancer Cells via Interfering with the MTOR Pathway and Inhibition of Calmodulin: In Vitro and Molecular Docking Studies, ACS Pharmacol. Transl. Sci., 3, 1330, 10.1021/acsptsci.0c00144
Pizzagalli, 2021, A Guide to Plasma Membrane Solute Carrier Proteins, FEBS J., 288, 2784, 10.1111/febs.15531
Rommasi, 2021, Liposomal Nanomedicine: Applications for Drug Delivery in Cancer Therapy, Nanoscale Res. Lett., 16, 95, 10.1186/s11671-021-03553-8
Kisiel, 2022, Multicancer Early Detection Test: Preclinical, Translational, and Clinical Evidence–Generation Plan and Provocative Questions, Cancer, 128, 861, 10.1002/cncr.33912
Baillie, 2019, Therapeutic Targeting of 3′, 5′-Cyclic Nucleotide Phosphodiesterases: Inhibition and Beyond, Nat. Rev. Drug Discov., 18, 770, 10.1038/s41573-019-0033-4
Fan, 2018, Updated Progress of Nanocarrier-Based Intranasal Drug Delivery Systems for Treatment of Brain Diseases, Crit. Rev. Ther. Drug Carr. Syst., 35, 433, 10.1615/CritRevTherDrugCarrierSyst.2018024697
Lu, 2019, Developmental Origins and Oncogenic Pathways in Malignant Brain Tumors, Wiley Interdiscip. Rev. Dev. Biol., 8, e342, 10.1002/wdev.342
Assaraf, 2019, The Multi-Factorial Nature of Clinical Multidrug Resistance in Cancer, Drug Resist. Updat., 46, 100645, 10.1016/j.drup.2019.100645
Pasello, 2020, The ABC Subfamily A Transporters: Multifaceted Players with Incipient Potentialities in Cancer, Semin. Cancer Biol., 60, 57, 10.1016/j.semcancer.2019.10.004
Wang, 2018, Curcumin Ameliorated Ventilator-Induced Lung Injury in Rats, Biomed. Pharmacother., 98, 754, 10.1016/j.biopha.2017.12.100
Abdelfatah, 2021, Isopetasin and S-Isopetasin as Novel P-Glycoprotein Inhibitors against Multidrug-Resistant Cancer Cells, Phytomedicine, 86, 153196, 10.1016/j.phymed.2020.153196
Tantawy, 2020, Thymoquinone-Chemotherapeutic Combinations: New Regimen to Combat Cancer and Cancer Stem Cells, Naunyn Schmiedeberg’s Arch. Pharmacol., 393, 1581, 10.1007/s00210-020-01898-y
Eid, 2020, The Carotenoid Fucoxanthin Can Sensitize Multidrug Resistant Cancer Cells to Doxorubicin via Induction of Apoptosis, Inhibition of Multidrug Resistance Proteins and Metabolic Enzymes, Phytomedicine, 77, 153280, 10.1016/j.phymed.2020.153280
Majidinia, 2020, Overcoming Multidrug Resistance in Cancer: Recent Progress in Nanotechnology and New Horizons, IUBMB Life, 72, 855, 10.1002/iub.2215
Hussain, 2020, Research Progress in Flavonoids as Potential Anticancer Drug Including Synergy with Other Approaches, Curr. Top. Med. Chem., 20, 1791, 10.2174/1568026620666200502005411
Figueira-Mansur, J., Schrago, C.G., Salles, T.S., Alvarenga, E.S.L., Vasconcellos, B.M., Melo, A.C.A., and Moreira, M.F. (2020). Phylogenetic Analysis of the ATP-Binding Cassette Proteins Suggests a New ABC Protein Subfamily J in Aedes Aegypti (Diptera: Culicidae). BMC Genom., 21.
Hanssen, 2021, Targeting Multidrug Resistance-Associated Protein 1 (MRP1)-Expressing Cancers: Beyond Pharmacological Inhibition, Drug Resist. Updat., 59, 100795, 10.1016/j.drup.2021.100795
Elfadadny, 2021, Role of Multidrug Resistance-Associated Proteins in Cancer Therapeutics: Past, Present, and Future Perspectives, Environ. Sci. Pollut. Res., 28, 49447, 10.1007/s11356-021-15759-5
Gao, 2021, Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment, ACS Nano, 15, 12567, 10.1021/acsnano.1c02103
Mohammad, 2018, Understanding of Human ATP Binding Cassette Superfamily and Novel Multidrug Resistance Modulators to Overcome MDR, Biomed. Pharmacother., 100, 335, 10.1016/j.biopha.2018.02.038
Sivák, L. (2019). Overcoming Cancer Resistance to Chemotherapy through HPMA Copolymer Conjugates. [Ph.D. Thesis, Univerzita Karlova-Přírodovědecká Fakulta].
Rather, 2020, Quercetin as an Innovative Therapeutic Tool for Cancer Chemoprevention: Molecular Mechanisms and Implications in Human Health, Cancer Med., 9, 9181, 10.1002/cam4.1411
Arvanitis, 2020, The Blood–Brain Barrier and Blood–Tumour Barrier in Brain Tumours and Metastases, Nat. Rev. Cancer, 20, 26, 10.1038/s41568-019-0205-x
Razzaq, S., Rauf, A., Raza, A., Akhtar, S., Tabish, T.A., Sandhu, M.A., Zaman, M., Ibrahim, I.M., Shahnaz, G., and Rahdar, A. (2021). A Multifunctional Polymeric Micelle for Targeted Delivery of Paclitaxel by the Inhibition of the P-Glycoprotein Transporters. Nanomaterials, 11.
Karthika, 2021, Incorporation of Natural Assumption to Deal with Cancer, Environ. Sci. Pollut. Res., 28, 4902, 10.1007/s11356-020-11479-4
Amawi, 2019, ABC Transporter-Mediated Multidrug-Resistant Cancer, Drug Transp. Drug Dispos. Eff. Toxic., 1141, 549
Wang, 2021, Multidrug Resistance Proteins (MRPs): Structure, Function and the Overcoming of Cancer Multidrug Resistance, Drug Resist. Updat., 54, 100743, 10.1016/j.drup.2021.100743
Sosnik, A., and Bendayan, R. (2019). Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Academic Press.
Goebel, 2021, The Roles of the Human ATP-Binding Cassette Transporters P-Glycoprotein and ABCG2 in Multidrug Resistance in Cancer and at Endogenous Sites: Future Opportunities for Structure-Based Drug Design of Inhibitors, Cancer Drug Resist., 4, 784
Power, J.F. (2018). The Role of Extracellular Vesicles in the Transfer of Multidrug Resistance in Human Ovarian Cancer Cells. [Master’s Thesis, Queen’s University].
Nanayakkara, 2018, Targeted Inhibitors of P-Glycoprotein Increase Chemotherapeutic-Induced Mortality of Multidrug Resistant Tumor Cells, Sci. Rep., 8, 967, 10.1038/s41598-018-19325-x
Cheng, 2019, Targeting Epigenetic Regulators for Cancer Therapy: Mechanisms and Advances in Clinical Trials, Signal Transduct. Target. Ther., 4, 62, 10.1038/s41392-019-0095-0
Richiardone, 2021, Impact of Cancer Metabolism on Therapy Resistance-Clinical Implications, Drug Resist. Updat., 59, 100797, 10.1016/j.drup.2021.100797
Kumar, 2020, Is Viral E6 Oncoprotein a Viable Target? A Critical Analysis in the Context of Cervical Cancer, Med. Res. Rev., 40, 2019, 10.1002/med.21697
Ross, 1999, Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitoxantrone-Selected Cell Lines, J. Natl. Cancer Inst., 91, 429, 10.1093/jnci/91.5.429
Nakanishi, 2012, Breast Cancer Resistance Protein (BCRP/ABCG2): Its Role in Multidrug Resistance and Regulation of Its Gene Expression, Chin. J. Cancer, 31, 73, 10.5732/cjc.011.10320
Folger, A., and Wang, Y. (2021). The Cytotoxicity and Clearance of Mutant Huntingtin and Other Misfolded Proteins. Cells, 10.
Brangi, 1999, Camptothecin Resistance: Role of the ATP-Binding Cassette (ABC), Mitoxantrone-Resistance Half-Transporter (MXR), and Potential for Glucuronidation in MXR-Expressing Cells, Cancer Res., 59, 5938
Lindner, 2013, Expression and Subcellular Localization of Efflux Transporter ABCG 2/BCRP in Important Tissue Barriers of Lactating Dairy Cows, Sheep and Goats, J. Vet. Pharmacol. Ther., 36, 562, 10.1111/jvp.12045
Abdallah, 2016, MRP1 Expression in CTCs Confers Resistance to Irinotecan-based Chemotherapy in Metastatic Colorectal Cancer, Int. J. Cancer, 139, 890, 10.1002/ijc.30082
Fu, 2013, Where Is It and How Does It Get There–Intracellular Localization and Traffic of P-Glycoprotein, Front. Oncol., 3, 321, 10.3389/fonc.2013.00321
Akter, R., Rahman, M., Kaushik, D., Mittal, V., Uivarosan, D., Nechifor, A.C., Behl, T., Karthika, C., Stoicescu, M., and Munteanu, M.A. (2021). Chemo-Preventive Action of Resveratrol: Suppression of P53—A Molecular Targeting Approach. Molecules, 26.
Waku, 2020, NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of P53 and Retinoblastoma Protein, Mol. Cell. Biol., 40, e00597, 10.1128/MCB.00597-19
Wang, 2020, β-Sitosterol Reverses Multidrug Resistance via BCRP Suppression by Inhibiting the P53–MDM2 Interaction in Colorectal Cancer, J. Agric. Food Chem., 68, 3850, 10.1021/acs.jafc.0c00107
Karthika, 2021, Multiple Strategies with the Synergistic Approach for Addressing Colorectal Cancer, Biomed. Pharmacother., 140, 111704, 10.1016/j.biopha.2021.111704
Eng, 2022, A Comprehensive Framework for Early-Onset Colorectal Cancer Research, Lancet Oncol., 23, e116, 10.1016/S1470-2045(21)00588-X
Mirmozaffari, 2020, Presenting an Expert System for Early Diagnosis of Gastrointestinal Diseases, Int. J. Gastroenterol. Sci., 1, 21, 10.33545/26649209.2019.v1.i1a.4
2019, Overcoming Transporter-Mediated Multidrug Resistance in Cancer: Failures and Achievements of the Last Decades, Drug Deliv. Transl. Res., 9, 379, 10.1007/s13346-018-0584-7
Recasens, 2019, Targeting Cancer Cell Dormancy, Trends Pharmacol. Sci., 40, 128, 10.1016/j.tips.2018.12.004
Karthika, 2019, Can Curcumin along with Chemotherapeutic Drug and Lipid Provide an Effective Treatment of Metastatic Colon Cancer and Alter Multidrug Resistance?, Med. Hypotheses, 132, 109325, 10.1016/j.mehy.2019.109325
Karthika, 2021, Curcumin as a Great Contributor for the Treatment and Mitigation of Colorectal Cancer, Exp. Gerontol., 152, 111438, 10.1016/j.exger.2021.111438
Herrera, 2018, Potential Use of Nanomedicine for the Anti-Inflammatory Treatment of Neurodegenerative Diseases, Curr. Pharm. Des., 24, 1589, 10.2174/1381612824666180403113015
Miere, F., Vicas, S.I., Timar, A.V., Ganea, M., Zdrinca, M., Cavalu, S., Fritea, L., Vicas, L., Muresan, M., and Pallag, A. (2021). Preparation and Characterization of Two Different Liposomal Formulations with Bioactive Natural Extract for Multiple Applications. Processes, 9.
Mitchell, 2021, Engineering Precision Nanoparticles for Drug Delivery, Nat. Rev. Drug Discov., 20, 101, 10.1038/s41573-020-0090-8
Cavalu, 2018, Novel Formulation Based on Chitosan-Arabic Gum Nanoparticles Entrapping Propolis Extract, Rev. Chim., 69, 3756, 10.37358/RC.18.12.6836
Bukowski, K., Kciuk, M., and Kontek, R. (2020). Mechanisms of Multidrug Resistance in Cancer Chemotherapy. Int. J. Mol. Sci., 21.
Chaudhary, M. (2022). Role of Plant Secondary Metabolites as Modulators of Multidrug Resistance in Cancer Therapy. Plant Secondary Metabolites, Springer.
Milewska, 2021, Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment, Int. J. Nanomed., 16, 6593, 10.2147/IJN.S323831
Maderuelo, 2019, Enteric Coating of Oral Solid Dosage Forms as a Tool to Improve Drug Bioavailability, Eur. J. Pharm. Sci., 138, 105019, 10.1016/j.ejps.2019.105019
Kodan, 2021, ABCB1/MDR1/P-gp Employs an ATP-dependent Twist-and-squeeze Mechanism to Export Hydrophobic Drugs, FEBS Lett., 595, 707, 10.1002/1873-3468.14018
Wang, 2018, Knockdown of the Wnt Receptor Frizzled-1 (FZD1) Reduces MDR1/P-Glycoprotein Expression in Multidrug Resistant Leukemic Cells and Inhibits Leukemic Cell Proliferation, Leuk. Res., 67, 99, 10.1016/j.leukres.2018.01.020
Ahmed, A.H. (2021). Identifying Anti-Cancer Drugs Targeting ALK Inhibitors with P-Glycoprotein and Studying It’s Molecular Mechanism of Transport. [Ph.D. Thesis, University of Georgia].
Duke, S.O., Owens, D.K., and Dayan, F.E. (2018). Natural Product-Based Chemical Herbicides. Weed Control, CRC Press.
Dallavalle, 2020, Improvement of Conventional Anti-Cancer Drugs as New Tools against Multidrug Resistant Tumors, Drug Resist. Updat., 50, 100682, 10.1016/j.drup.2020.100682
Ganesan, 2021, Phytochemicals Reverse P-Glycoprotein Mediated Multidrug Resistance via Signal Transduction Pathways, Biomed. Pharmacother., 139, 111632, 10.1016/j.biopha.2021.111632
Zargan, 2022, Evaluation of the Anti-Cancer Effect of Curcumin on MCF-7 Cells in 3D Culture Conditions to Increase the Efficacy of Breast Cancer Treatment, J. Appl. Biotechnol. Rep., 9, 547
Amodio, V., Mauri, G., Reilly, N.M., Sartore-Bianchi, A., Siena, S., Bardelli, A., and Germano, G. (2021). Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers. Cancers, 13.
Layos, 2021, Curcumin: A Therapeutic Strategy for Colorectal Cancer?, Semin. Cancer Biol., 73, 321, 10.1016/j.semcancer.2020.09.004
Markovic, 2019, Lipidic Prodrug Approach for Improved Oral Drug Delivery and Therapy, Med. Res. Rev., 39, 579, 10.1002/med.21533
Rajput, 2021, Lymphatic Transport System to Circumvent Hepatic Metabolism for Oral Delivery of Lipid-Based Nanocarriers, J. Drug Deliv. Sci. Technol., 66, 102934, 10.1016/j.jddst.2021.102934
Rawal, 2019, Threatening Cancer with Nanoparticle Aided Combination Oncotherapy, J. Control. Release, 301, 76, 10.1016/j.jconrel.2019.03.015
Degors, 2019, Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors, Acc. Chem. Res., 52, 1750, 10.1021/acs.accounts.9b00177
Liu, 2019, ABC Family Transporters, Drug Transporters in Drug Disposition, Effects and Toxicity, Volume 1141, 13, 10.1007/978-981-13-7647-4_2
Karthika, C., Sureshkumar, R., Sajini, D.V., Ashraf, G.M., and Rahman, M. (2022). 5-Fluorouracil and Curcumin with Pectin Coating as a Treatment Regimen for Titanium Dioxide with Dimethylhydrazine-Induced Colon Cancer Model. Environ. Sci. Pollut. Res., 1–14.
Salehi, 2020, Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health, ACS Omega, 5, 11849, 10.1021/acsomega.0c01818