Multicentric Castleman's disease treated with antivirals and immunosuppressants

Journal of Medical Virology - Tập 71 Số 3 - Trang 399-403 - 2003
Sanjaya Senanayake1, John V. Kelly1, Andrew R. Lloyd2, Zubair Waliuzzaman3, David Goldstein4, William D . Rawlinson5,6
1Department of Infectious Diseases, Prince of Wales Hospital, Randwick, New South Wales, Australia
2School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
3Department of Microbiology, Virology Division, Prince of Wales Hospital, Randwick, New South Wales, Australia
4Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales, Australia
5Department of Microbiology, Virology Division, SEALS Prince of Wales Hospital, Randwick, New South Wales, Australia
6School of Biochemistry and Biomedical Sciences and School of Medical Sciences University of New South Wales, New South Wales, Australia

Tóm tắt

AbstractA patient negative for human immunodeficiency virus (HIV) developed multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS) associated with active human herpesvirus 8 (HHV‐8) infection. He was treated with sequential antiviral therapy, chemotherapy, and corticosteroids. HHV‐8 levels were monitored throughout the course of the patient's illness, and were found to rise on relapse. No consistent change in HHV‐8 levels was found with antiviral therapy. We demonstrate that in this patient antiviral therapy was clinically ineffective, and did not alter HHV‐8 levels, but that corticosteroid and combination chemotherapy led to clinical improvement. Despite the implication of HHV‐8 as a cause of MCD, few studies have correlated HHV‐8 levels with clinical response. J. Med. Virol. 71:399–403, 2003. © 2003 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1128/AAC.43.2.377

10.1038/nrc797

10.1002/(SICI)1097-0142(19990201)85:3<706::AID-CNCR21>3.0.CO;2-7

10.1126/science.7997879

10.1002/1096-8652(200012)65:4<310::AID-AJH11>3.0.CO;2-G

10.1182/blood.V98.12.3473

10.1093/jnci/93.3.194

10.1073/pnas.96.8.4546

10.1182/blood.V95.4.1406.004k26_1406_1412

Grulich AE, 2001, Human herpesvirus 8: a new sexually transmissible infection, Venereology, 14, 174

10.7326/0003-4819-128-8-199804150-00010

10.1002/1097-0142(197203)29:3<670::AID-CNCR2820290321>3.0.CO;2-#

10.1016/S0166-0934(96)02139-8

Low P, 1998, Suppression of HHV‐8 viremia by foscarnet in an HIV‐infected patient with Kaposi's sarcoma and HHV‐8 associated hemophagocytic syndrome, Eur J Med Res, 3, 461

Murakami‐Mori K, 1997, Enhancement of gp130‐mediated tyrosine phosphorylation of STAT3 and its DNA‐binding activity in dexamethasone‐treated AIDS‐associated Kaposi's sarcoma cells: selective synergy between dexamethasone and gp130‐related growth factors in Kaposi's sarcoma cell proliferation, J Immunol, 158, 5518, 10.4049/jimmunol.158.11.5518

10.1128/AAC.41.12.2754

10.1182/blood.V95.1.56.001k13_56_61

Oksenhendler E, 2000, High levels of human herpesvirus 8 viral load, human interleukin‐6, interleukin‐10 and C‐reactive protein correlate with exacerbation of multicentric Castleman disease in HIV infected patients, Blood, 96, 2069, 10.1182/blood.V96.6.2069.h8002069_2069_2073

10.1002/mpo.2950180416

10.1093/jac/45.suppl_4.15

10.1182/blood.V86.4.1276.bloodjournal8641276

10.1128/JVI.73.5.4181-4187.1999

10.1046/j.1440-1827.2001.01266.x

10.1128/JCM.40.11.4346-4348.2002

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Journal of Medical Virology

Tập 71 Số 3

399-403

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