Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood‐brain barrier development

Developmental Dynamics - Tập 202 Số 2 - Trang 172-180 - 1995
Ying� Qin1, Thomas N. Sato1
1Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110.

Tóm tắt

AbstractMolecular mechanisms of endothelial cell differentiation during blood‐brain barrier (BBB) development is not well understood due to the lack of specific molecular markers. Here we describe that expression of the mouse multidrug resistance la/3 (mdrla/3) gene can be detected specifically in subsets of vascular endothelial cells associated with neural tissues at as early as embryonic day 10.5 (E10.5). This onset of mdrla/3 gene expression coincides with the previously described first appearance of morphologically distinct endothelial cells in neural tissues during BBB development. To our knowledge, the mdrla/3 gene is the earliest endothelial cell differentiation marker gene during BBB development described thus far. In addition, we have found that neither the level nor pattern of mdrla/3 gene expression in BBB endothelial cells is affected by aberrant cortical neuronal layers in mutant mouse reeler. © 1995 Wiley‐Liss, Inc.

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Developmental Dynamics

Tập 202 Số 2

172-180

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