Most gene fusions in cancer are stochastic events

Genes Chromosomes and Cancer - Tập 58 Số 9 - Trang 607-611 - 2019
Bertil Johansson1, Fredrik Mertens1, Tommy Schyman2, Jonas Björk2, Nils Mandahl1, Felix Mitelman1
1Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
2Occupational and Environmental Medicine, Lund University, Lund, Sweden

Tóm tắt

AbstractCancer‐associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have a biologic impact. By ascertaining the chromosomal locations of 8934 genes involved in 10 861 gene fusions reported in the literature, we here show that there is a highly significant association between gene content of chromosomes and chromosome bands and number of genes involved in fusions. This strongly suggests that a clear majority of gene fusions detected by MPS are stochastic events associated with the number of genes available to participate in fusions and that most reported gene fusions are passengers without any pathogenetic importance.

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Genes Chromosomes and Cancer

Tập 58 Số 9

607-611

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