Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
Tóm tắt
Cell death is a fundamental biological phenomenon that is essential for the survival and development of an organism. Emerging evidence also indicates that cell death contributes to immune defense against infectious diseases. Pyroptosis is a form of inflammatory programmed cell death pathway activated by human and mouse caspase‐1, human caspase‐4 and caspase‐5, or mouse caspase‐11. These inflammatory caspases are used by the host to control bacterial, viral, fungal, or protozoan pathogens. Pyroptosis requires cleavage and activation of the pore‐forming effector protein gasdermin D by inflammatory caspases. Physical rupture of the cell causes release of the pro‐inflammatory cytokines
Từ khóa
Tài liệu tham khảo
Man SM, 2017, Generation of a caspase‐1‐deficient mouse line to study the differential roles of caspase‐1 and caspase‐11 inflammasomes, Sci Rep
Ushio S, 1996, Cloning of the cDNA for human IFN‐gamma‐inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein, J Immunol, 156, 4274, 10.4049/jimmunol.156.11.4274
Ryu JC, 2016, Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2, Mucosal Immunol
Pallett MA, 2016, Bacterial virulence factor inhibits caspase‐4/11 activation in intestinal epithelial cells, Mucosal Immunol
Caution K, 2015, Caspase‐11 and caspase‐1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance, Sci Rep‐UK