Molecular imaging promotes progress in orthopedic research

Weissleder, 2001, Molecular imaging, Radiology, 219, 316, 10.1148/radiology.219.2.r01ma19316

Rudin, 2003, Molecular imaging in drug discovery and development, Nat. Rev., Drug Discov., 2, 123, 10.1038/nrd1007

Jaffer, 2005, Molecular imaging in the clinical arena, JAMA, 293, 855, 10.1001/jama.293.7.855

Tai, 2005, Instrumentation aspects of animal PET, Annu. Rev. Biomed. Eng., 7, 255, 10.1146/annurev.bioeng.6.040803.140021

Gambhir, 2000, Imaging transgene expression with radionuclide imaging technologies, Neoplasia, 2, 118, 10.1038/sj.neo.7900083

Licha, 2005, Optical imaging in drug discovery and diagnostic applications, Adv. Drug Deliv. Rev., 57, 1087, 10.1016/j.addr.2005.01.021

Weissleder, 2003, Shedding light onto live molecular targets, Nat. Med., 9, 123, 10.1038/nm0103-123

Basilion, 2005, Magnetic resonance imaging: utility as a molecular imaging modality, Curr. Top Dev. Biol., 70, 1, 10.1016/S0070-2153(05)70001-6

Bulte, 2001, Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells, Nat. Biotechnol., 19, 1141, 10.1038/nbt1201-1141

Hinds, 2003, Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells, Blood, 102, 867, 10.1182/blood-2002-12-3669

Kostura, 2004, Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis, NMR Biomed., 17, 513, 10.1002/nbm.925

Arbab, 2005, Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells, NMR Biomed., 18, 553, 10.1002/nbm.991

Mayer-Kuckuk, 2004, Role of reporter gene imaging in molecular and cellular biology, Biol. Chem., 385, 353, 10.1515/BC.2004.039

Zhao, 2005, Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo, J. Biomed. Opt., 10, 41210, 10.1117/1.2032388

Weissleder, 1999, In vivo imaging of tumors with protease-activated near-infrared fluorescent probes, Nat. Biotechnol., 17, 375, 10.1038/7933

Bremer, 2001, In vivo molecular target assessment of matrix metalloproteinase inhibition, Nat. Med., 7, 743, 10.1038/89126

Caplan, 2005, Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics, Tissue Eng., 11, 1198, 10.1089/ten.2005.11.1198

Gao, 2001, The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion, Cells Tissues Organs, 169, 12, 10.1159/000047856

Allers, 2004, Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice, Transplantation, 78, 503, 10.1097/01.TP.0000128334.93343.B3

Chin, 2003, 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction, Nucl. Med. Commun., 24, 1149, 10.1097/00006231-200311000-00005

Barbash, 2003, Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution, Circulation, 108, 863, 10.1161/01.CIR.0000084828.50310.6A

Kraitchman, 2005, Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction, Circulation, 112, 1451, 10.1161/CIRCULATIONAHA.105.537480

Mayer-Kuckuk, 2005, High-resolution imaging of bone precursor cells within the intact bone marrow cavity of living mice, Mol. Ther., 12, 33, 10.1016/j.ymthe.2005.02.018

Leo, 2004, In vivo bioluminescent imaging of virus-mediated gene transfer and transduced cell transplantation in the intervertebral disc, Spine, 29, 838, 10.1097/00007632-200404150-00004

Ducy, 2000, The osteoblast: a sophisticated fibroblast under central surveillance, Science, 289, 1501, 10.1126/science.289.5484.1501

Kalajzic, 2002, Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters, Bone, 31, 654, 10.1016/S8756-3282(02)00912-2

Kalajzic, 2002, Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage, J. Bone Miner. Res., 17, 15, 10.1359/jbmr.2002.17.1.15

Honigman, 2001, Imaging transgene expression in live animals, Mol. Ther., 4, 239, 10.1006/mthe.2001.0437

Iris, 2003, Molecular imaging of the skeleton: quantitative real-time bioluminescence monitoring gene expression in bone repair and development, J. Bone Miner. Res., 18, 570, 10.1359/jbmr.2003.18.3.570

Hasharoni, 2005, Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2, J. Neurosurg. Spine, 3, 47, 10.3171/spi.2005.3.1.0047

Boskey, 2005, Infrared analysis of bone in health and disease, J. Biomed Opt., 10, 031102, 10.1117/1.1922927

Carden, 2000, Application of vibrational spectroscopy to the study of mineralized tissues (review), J. Biomed Opt., 5, 259, 10.1117/1.429994

Draper, 2005, Novel assessment of bone using time-resolved transcutaneous Raman spectroscopy, J. Bone Miner. Res., 20, 1968, 10.1359/JBMR.050710

Zaheer, 2001, In vivo near-infrared fluorescence imaging of osteoblastic activity, Nat. Biotechnol., 19, 1148, 10.1038/nbt1201-1148

Fleisch, 1998, Bisphosphonates: mechanisms of action, Endocr. Rev., 19, 80, 10.1210/edrv.19.1.0325

Kalikin, 2003, In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised mice, Cancer Biol. Ther., 2, 656, 10.4161/cbt.2.6.531

Schneider, 2005, Bone turnover mediates preferential localization of prostate cancer in the skeleton, Endocrinology, 146, 1727, 10.1210/en.2004-1211

Wetterwald, 2002, Optical imaging of cancer metastasis to bone marrow: a mouse model of minimal residual disease, Am. J. Pathol., 160, 1143, 10.1016/S0002-9440(10)64934-6

Kang, 2005, Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway, Proc. Natl. Acad. Sci. U. S. A., 102, 13909, 10.1073/pnas.0506517102

Ciana, 2001, Engineering of a mouse for the in vivo profiling of estrogen receptor activity, Mol. Endocrinol., 15, 1104, 10.1210/mend.15.7.0658

Ciana, 2003, In vivo imaging of transcriptionally active estrogen receptors, Nat. Med., 9, 82, 10.1038/nm809

van den Berg, 2001, Lessons from animal models of osteoarthritis, Curr. Opin. Rheumatol., 13, 452, 10.1097/00002281-200109000-00019

Lee, 2001, Rheumatoid arthritis, Lancet, 358, 903, 10.1016/S0140-6736(01)06075-5

Creamer, 1997, Osteoarthritis, Lancet, 350, 503, 10.1016/S0140-6736(97)07226-7

Henrotin, 2003, The role of reactive oxygen species in homeostasis and degradation of cartilage, Osteoarthr. Cartil., 11, 747, 10.1016/S1063-4584(03)00150-X

Chen, 2004, Imaging reactive oxygen species in arthritis, Mol. Imaging, 3, 159, 10.1162/1535350042380290

Firestein, 2003, Evolving concepts of rheumatoid arthritis, Nature, 423, 356, 10.1038/nature01661

Carlsen, 2002, In vivo imaging of NF-kappa B activity, J. Immunol., 168, 1441, 10.4049/jimmunol.168.3.1441

Zhang, 2003, An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice, J. Immunol., 170, 6307, 10.4049/jimmunol.170.12.6307

Zhang, 2005, Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition, J. Immunol., 174, 8125, 10.4049/jimmunol.174.12.8125

Nakashima-Matsushita, 1999, Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis, Arthritis Rheum., 42, 1609, 10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L

Turk, 2002, Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis, Arthritis Rheum., 46, 1947, 10.1002/art.10405

Hansch, 2004, In vivo imaging of experimental arthritis with near-infrared fluorescence, Arthritis Rheum., 50, 961, 10.1002/art.20112

Kekow, 2000, Multifunctional role of proteases in rheumatic diseases, Adv. Exp. Med. Biol., 477, 467, 10.1007/0-306-46826-3_47

Wunder, 2004, In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response, Arthritis Rheum., 50, 2459, 10.1002/art.20379

Wipke, 2002, Dynamic visualization of a joint-specific autoimmune response through positron emission tomography, Nat. Immunol., 3, 366, 10.1038/ni775

Wipke, 2004, Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes, J. Immunol., 172, 7694, 10.4049/jimmunol.172.12.7694

Ji, 2002, Arthritis critically dependent on innate immune system players, Immunity, 16, 157, 10.1016/S1074-7613(02)00275-3

Nakajima, 2001, Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis, J. Clin. Invest., 107, 1293, 10.1172/JCI12037

Wunder, 2005, Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis, Mol. Imaging, 4, 1, 10.1162/15353500200504142

Massoud, 2003, Molecular imaging in living subjects: seeing fundamental biological processes in a new light, Genes Dev., 17, 545, 10.1101/gad.1047403

Ntziachristos, 2005, Looking and listening to light: the evolution of whole-body photonic imaging, Nat. Biotechnol., 23, 313, 10.1038/nbt1074