Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth

Springer Science and Business Media LLC - Tập 14 - Trang 175-182 - 2000
Mark P. Mattson1,2, Robert C. Haddon3, Apparao M. Rao4
1Sanders-Brown Research Center on Aging and Department of Anatomy and Neurobiology, University of Kentucky, Lexington
2Laboratory of Neurosciences, National Institute on Aging, Baltimore
3Department of Chemistry and Physics, University of Kentucky, Lexington
4Center for Applied Energy Research and Department of Physics and Astronomy, University of Kentucky, Lexington

Tóm tắt

Carbon nanotubes are strong, flexible, conduct electrical current, and can be functionalized with different molecules, properties that may be useful in basic and applied neuroscience research. We report the first application of carbon nanotube technology to neuroscience research. Methods were developed for growing embryonic rat-brain neurons on multiwalled carbon nanotubes. On unmodified nanotubes, neurons extend only one or two neurites, which exhibit very few branches. In contrast, neurons grown on nanotubes coated with the bioactive molecule 4-hydroxynonenal elaborate multiple neurites, which exhibit extensive branching. These findings establish the feasability of using nanotubes as substrates for nerve cell growth and as probes of neuronal function at the nanometer scale.

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Springer Science and Business Media LLC

Tập 14

175-182

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