Molecular biology of testicular germ cell tumors

Clinical and Translational Oncology - Tập 18 - Trang 550-556 - 2015
R. Gonzalez-Exposito1, M. Merino2, C. Aguayo3
1Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
2Hospital Universitario Infanta Sofia, Madrid, Spain
3Hospital Universitario Fundacion, Alcorcon, Spain

Tóm tắt

Testicular germ cell tumors (TGCTs) are the most common solid tumors in young adult men. They constitute a unique pathology because of their embryonic and germ origin and their special behavior. Genetic predisposition, environmental factors involved in their development and genetic aberrations have been under study in many works throughout the last years trying to explain the susceptibility and the transformation mechanism of TGCTs. Despite the high rate of cure in this type of tumors because its particular sensitivity to cisplatin, there are tumors resistant to chemotherapy for which it is needed to find new therapies. In the present work, it has been carried out a literature review on the most important molecular aspects involved in the onset and development of such tumors, as well as a review of the major developments regarding prognostic factors, new prognostic biomarkers and the possibility of new targeted therapies.

Tài liệu tham khảo

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