Molecular Prognostic and Predictive Markers in Colorectal Cancer: Current Status
Tóm tắt
Tài liệu tham khảo
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225–49.
•• Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008; 359:1757–1765. This article demonstrated KRAS’ predictive value in patients with mCRC receiving cetuximab, an EGFR inhibitor.
• Grady WM, Carethers JM. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology 2008; 135:1079–1099. This article is a comprehensive review of genetic and epigenetic changes that occur during CRC development and metastasis.
Bokemeyer C, Bondarenko I, Hartmann JT, et al. Biomarkers predictive for outcome on patients with metastatic colorectal cancer treated with first-line FOLFOX4 plus or minus cetuximab: updated data from the OPUS study [Abstract: 428]. Presented at the 2010 Gastrointestinal Cancers Symposium. Orlando, Florida; January 22–24, 2010
Soumaoro LT, Uetake H, Higuchi T, et al. Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. Clin Cancer Res. 2004;10:8465–71.
Ogino S, Kirkner GJ, Nosho K, et al. Cyclooxygenase-2 is an independent predictor of poor prognosis in colon cancer. Clin Cancer Res. 2008;14:8221–7.