Molecular Biology and Pathogenesis of Viral Myocarditis

Annual Review of Pathology: Mechanisms of Disease - Tập 3 Số 1 - Trang 127-155 - 2008
Mitra Esfandiarei1,2, Bruce M. McManus2
1Child & Family Research Institute, Department of Cardiovascular Sciences, and Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver V5Z 4H4, Canada;
2The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Providence Health Care Research Institute, Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver V6Z 1Y6, Canada;

Tóm tắt

Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. Several viruses have been associated with myocarditis in humans. However, coxsackievirus B3 is still considered the dominant etiological agent. The observed pathology in viral myocarditis is a result of cooperation or teamwork between viral processes and host immune responses at various stages of disease. Both innate and adaptive immune responses are crucial determinants of the severity of myocardial damage, and contribute to the development of chronic myocarditis and dilated cardiomyopathy following acute viral myocarditis. Advances in genomics and proteomics, and in the use of informatics and biostatistics, are allowing unbiased initial evaluations that can be the basis for testable hypotheses about virus pathogenesis and new therapies.

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Annual Review of Pathology: Mechanisms of Disease

Tập 3 Số 1

127-155

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