Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases

Food Science and Human Wellness - Tập 12 - Trang 959-974 - 2023
Lei Tian1, Ruixiang Zhao2, Xinyi Xu1, Zhiwei Zhou1, Xiaofang Xu1, Dongmei Luo1, Zhiqiang Zhou3, Yu Liu4, Ariel Kushmaro5, Robert S. Marks5, András Dinnyés1,6,7,8, Qun Sun1,3
1Key Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China
2Institute for Marine and Antarctic Studies, University of Tasmania, Newnham 7248, Australia
3College of Biomass Science and Engineering, Sichuan University, Chengdu 610064, China
4Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China
5Avram and Stella Goldstein-Goren, Department of Biotechnology Engineering, Faculty of Engineering Sciences, Ben Gurion University of the Negev, Beer-Sheva 84105, Israel
6BioTalentum Ltd., Gödöllő, 2100, Hungary
7Department of Cell Biology and Molecular Medicine, University of Szeged, Szeged H-6270, Hungary
8Hungarian University of Agriculture and Life Sciences, Institute of Physiology and Animal Nutrition, Department of Physiology and Animal Health, Gödöllő 2100, Hungary

Tài liệu tham khảo

Abdelhamid, 2019, Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining, EPMA J, 10, 337, 10.1007/s13167-019-00184-z Garcia-Gonzalez, 2021, Health-promoting role of Lactiplantibacillus plantarum isolated from fermented foods, Microorganisms, 9, 10.3390/microorganisms9020349 Chong, 2019, Lactobacillus plantarum DR7 improved upper respiratory tract infections via enhancing immune and inflammatory parameters: a randomized, double-blind, placebo-controlled study, J. Dairy Sci, 102, 4783, 10.3168/jds.2018-16103 Wang, 2020, A recombinant Lactobacillus plantarum strain expressing the spike protein of SARS-CoV-2, Int. J. Biol. Macromol., 160, 736, 10.1016/j.ijbiomac.2020.05.239 Xu, 2021, Boosting vaccine-elicited respiratory mucosal and systemic COVID-19 immunity in mice with the oral Lactobacillus plantarum, Front. Nutr., 8, 10.3389/fnut.2021.789242 Song, 2021, Lactobacillus plantarum DP189 prevents cognitive dysfunction in D-galactose/AlCl3 induced mouse model of Alzheimer's disease via modulating gut microbiota and PI3K/Akt/GSK-3β signaling pathway, Nutr. Neurosci., 1 Mensi, 2021, Lactobacillus plantarum PS128 and other probiotics in children and adolescents with autism spectrum disorder: a real-world experience, Nutrients, 13, 10.3390/nu13062036 Liu, 2018, New perspectives of Lactobacillus plantarum as a probiotic: the gut-heart-brain axis, J. Microbiol, 56, 601, 10.1007/s12275-018-8079-2 Cai, 2021, Reducing the reproductive toxicity activity of Lactiplantibacillus plantarum: a review of mechanisms and prospects, Environ. Sci. Pollut. Res., 28, 36927, 10.1007/s11356-021-14403-6 Fidanza, 2021, Lactiplantibacillus plantarum-nomad and ideal probiotic, Front. Microbiol., 12, 10.3389/fmicb.2021.712236 GBD 2019 Risk Factors Collaborators, 2020, Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019, Lancet, 396, 1223, 10.1016/S0140-6736(20)30752-2 Abdul-Ghani, 2006, Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study, Diabetes, 55, 1430, 10.2337/db05-1200 Wang, 2018, 2020 vision - an overview of prospects for diabetes management and prevention in the next decade, Diabetes Res. Clin. Pract, 143, 101, 10.1016/j.diabres.2018.06.007 Yang, 2021, Hypoglycemic effects of space-induced Lactobacillus plantarum SS18-5 on type 2 diabetes in a rat model, J. Food Biochem, 45, 10.1111/jfbc.13899 Li, 2016, Effects of Lactobacillus plantarum CCFM0236 on hyperglycaemia and insulin resistance in high-fat and streptozotocin-induced type 2 diabetic mice, J. Appl. Microbiol, 121, 1727, 10.1111/jam.13276 Gulnaz, 2021, Lactobacillus sps in reducing the risk of diabetes in high-fat diet-Induced diabetic mice by modulating the gut microbiome and inhibiting key digestive enzymes associated with diabetes, Biology, 10, 10.3390/biology10040348 Wu, 2021, Exploring the antioxidant effect of Lactobacillus plantarum SCS2 on mice with type 2 diabetes, J. Food Biochem, 10.1111/jfbc.13781 Youn, 2021, Lactobacillus plantarum reduces low-grade inflammation and glucose levels in a mouse model of chronic stress and diabetes, Infect. Immun., 89, 10.1128/IAI.00615-20 Cunningham, 2021, Gut microbiota influence in type 2 diabetes mellitus (T2DM, Gut Pathog, 13, 50, 10.1186/s13099-021-00446-0 Kocsis, 2020, Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: a meta-analysis of randomized clinical trials, Sci. Rep., 10, 11787, 10.1038/s41598-020-68440-1 Larsen, 2010, Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults, PLoS One, 5, 10.1371/journal.pone.0009085 Luo, 2021, Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e-GLP-1 in monkey model, Synth. Syst. Biotechnol., 6, 272, 10.1016/j.synbio.2021.09.009 Ríos-Covián, 2016, Intestinal short chain fatty acids and their link with diet and human health, Front. Microbiol., 7, 185, 10.3389/fmicb.2016.00185 Wang, 2022, Lactobacillus plantarum SHY130 isolated from yak yogurt attenuates hyperglycemia in C57BL/6J mice by regulating the enteroinsular axis, Food Funct, 13, 675, 10.1039/D1FO02387J Lee, 2021, Lactobacillus plantarum HAC01 ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced diabetic mice in association with modulating the gut microbiota, Food Funct, 12, 6363, 10.1039/D1FO00698C Oh, 2021, Lactobacillus plantarum HAC01 supplementation improves glycemic control in prediabetic subjects: a randomized, double-blind, placebo-controlled trial, Nutrients, 13, 10.3390/nu13072337 Rouxinol-Dias, 2016, Probiotics for the control of obesity - its effect on weight change, Porto. Biomed. J, 1, 12, 10.1016/j.pbj.2016.03.005 Nakamura, 2016, Fragmented lactic acid bacterial cells activate peroxisome proliferator-activated receptors and ameliorate dyslipidemia in obese mice, J. Agric. Food Chem., 64, 2549, 10.1021/acs.jafc.5b05827 Cai, 2020, Lactobacillus plantarum FRT10 alleviated high-fat diet-induced obesity in mice through regulating the PPARα signal pathway and gut microbiota, Appl. Microbiol. Biotechnol., 104, 5959, 10.1007/s00253-020-10620-0 Huang, 2021, Modulation of the gut microbiome and obesity biomarkers by Lactobacillus plantarum KC28 in a diet-Induced obesity murine model, Probiotics Antimicrob, Proteins, 13, 677 Gan, 2020, Anti-obesity effect of Lactobacillus plantarum CQPC01 by modulating lipid metabolism in high-fat diet-induced C57BL/6 mice, J. Food Biochem, 44, 10.1111/jfbc.13491 Choi, 2020, Lactobacillus plantarum LMT1-48 exerts anti-obesity effect in high-fat diet-induced obese mice by regulating expression of lipogenic genes, Sci. Rep., 10, 869, 10.1038/s41598-020-57615-5 Bäckhed, 2004, The gut microbiota as an environmental factor that regulates fat storage, Proc. Natl. Acad. Sci., 101, 15718, 10.1073/pnas.0407076101 Duranti, 2017, Obesity and microbiota: an example of an intricate relationship, Genes Nutr, 12, 18, 10.1186/s12263-017-0566-2 Eaimworawuthikul, 2017, Diet-induced obesity, gut microbiota and bone, including alveolar bone loss, Arch. Oral Biol., 78, 65, 10.1016/j.archoralbio.2017.02.009 Park, 2017, Lactobacillus plantarum HAC01 regulates gut microbiota and adipose tissue accumulation in a diet-induced obesity murine model, Appl. Microbiol. Biotechnol., 101, 1605, 10.1007/s00253-016-7953-2 Hussain, 2020, Anti-obesity effect of Lactobacillus plantarum LB8, 18 is associated with regulation of gut microbiota in high-fat diet-fed obese mice, J. Med. Food, 23, 750 In Kim, 2019, Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 simultaneously alleviate high-fat diet-induced colitis, endotoxemia, liver steatosis, and obesity in mice, Nutr. Res., 67, 78, 10.1016/j.nutres.2019.03.008 Liu, 2018, Epidemiology of urolithiasis in Asia, J. Urol., 5, 205 Thongprayoon, 2020, Determining the true burden of kidney stone disease, Nat. Rev. Nephrol., 16, 736, 10.1038/s41581-020-0320-7 Singh, 2021, The genetics of kidney stone disease and nephrocalcinosis, Nat. Rev. Nephrol Tundo, 2018, Gender equivalence in the prevalence of nephrolithiasis among adults younger than 50 years in the United States, J. Urol., 200, 1273, 10.1016/j.juro.2018.07.048 Vaughan, 2019, Predictors of symptomatic kidney stone recurrence after the first and subsequent episodes, Mayo Clin. Proc., 94, 202, 10.1016/j.mayocp.2018.09.016 Garbens, 2021, Causes and prevention of kidney stones: separating myth from fact, BJU Int, 128, 661, 10.1111/bju.15532 Alelign, 2018, Kidney stone disease: an update on current concepts, Adv. Meteorol., 2018, 3068365 Liu, 2017, The association of nephrolithiasis with metabolic syndrome and its components: a cross-sectional analysis, Ther. Clin. Risk Manage, 13, 41, 10.2147/TCRM.S125480 Rodríguez, 2015, Minimally invasive surgical treatment for kidney stone disease, Adv. Chronic Kidney Dis, 22, 266, 10.1053/j.ackd.2015.03.005 Lieske, 2017, Probiotics for prevention of urinary stones, Ann. Transl. Med., 5, 29, 10.21037/atm.2016.11.86 Paul, 2018, Designer probiotic Lactobacillus plantarum expressing oxalate decarboxylase developed using group II intron degrades intestinal oxalate in hyperoxaluric rats, Microbiol. Res., 215, 65, 10.1016/j.micres.2018.06.009 Sasikumar, 2014, Recombinant Lactobacillus plantarum expressing and secreting heterologous oxalate decarboxylase prevents renal calcium oxalate stone deposition in experimental rats, J. Biomed. Sci, 21, 86, 10.1186/s12929-014-0086-y Liu, 2021, Lactiplantibacillus plantarum reduced renal calcium oxalate stones by regulating arginine metabolism in gut microbiota, Front. Microbiol., 12 Wei, 2021, Probiotic Lactiplantibacillus plantarum N-1 could prevent ethylene glycol-induced kidney stones by regulating gut microbiota and enhancing intestinal barrier function, FASEB J, 35, 10.1096/fj.202100887RR Tian, 2022, Lactiplantibacillus plantarum J-15 reduced calcium oxalate kidney stones by regulating intestinal microbiota, metabolism and inflammation in rats, FASEB J, 10.1096/fj.202101972RR Le, 2021, 2019 global NAFLD prevalence: a systematic review and meta-analysis, Clin. Gastroenterol. Hepatol Zelber-Sagi, 2016, Lifestyle changes for the treatment of nonalcoholic fatty liver disease: a review of observational studies and intervention trials, Ther. Adv. Gastroenterol., 9, 392, 10.1177/1756283X16638830 Paul, 2018, Diagnosis and management of nonalcoholic fatty liver disease, JAMA, 320, 2474, 10.1001/jama.2018.17365 Kelishadi, 2013, Probiotics as a novel treatment for non-alcoholic fatty liver disease; a systematic review on the current evidence, Hepatitis Mon, 13 Younossi, 2016, Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes, Hepatology, 64, 73, 10.1002/hep.28431 Borrelli, 2018, Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: current and innovative therapeutic approaches, Redox Biol, 15, 467, 10.1016/j.redox.2018.01.009 Park, 2020, Beneficial effects of Lactobacillus plantarum strains on non-alcoholic fatty liver disease in high fat/high fructose diet-fed rats, Nutrients, 12, 10.3390/nu12020542 Chen, 2020, The protective mechanism of Lactobacillus plantarum FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet, Food Funct, 11, 3316, 10.1039/C9FO03003D Wang, 2021, Lactobacillus plantarum MA2 ameliorates methionine and choline-deficient diet induced non-alcoholic fatty liver disease in rats by improving the intestinal microecology and mucosal barrier, Foods, 10, 10.3390/foods10123126 Li, 2020, Probiotic mixture of Lactobacillus plantarum strains improves lipid metabolism and gut microbiota structure in high fat diet-fed mice, Front. Microbiol., 11, 512, 10.3389/fmicb.2020.00512 Zhao, 2019, Lactobacillus plantarum NA136 improves the non-alcoholic fatty liver disease by modulating the AMPK/Nrf2 pathway, Appl. Microbiol. Biotechnol., 103, 5843, 10.1007/s00253-019-09703-4 Zhao, 2020, Lactobacillus plantarum NA136 ameliorates nonalcoholic fatty liver disease by modulating gut microbiota, improving intestinal barrier integrity, and attenuating inflammation, Appl. Microbiol. Biotechnol., 104, 5273, 10.1007/s00253-020-10633-9 Shao, 2017, Lactobacillus plantarum HNU082-derived improvements in the intestinal microbiome prevent the development of hyperlipidaemia, Food Funct, 8, 4508, 10.1039/C7FO00902J Tian, 2022, Probiotic characteristics of Lactiplantibacillus plantarum N-1 and its cholesterol-lowering effect in hypercholesterolemic rats, Probiotics Antimicrob, Proteins Yang, 2021, Probiotic effects of Lactobacillus fermentum ZJUIDS06 and Lactobacillus plantarum ZY08 on hypercholesteremic golden hamsters, Front. Nutr., 8, 10.3389/fnut.2021.705763 Heo, 2018, Lactobacillus plantarum LRCC 5273 isolated from Kimchi ameliorates diet-induced hypercholesterolemia in C57BL/6 mice, Biosci. Biotechnol. Biochem, 82, 1964, 10.1080/09168451.2018.1497939 Qu, 2020, Reduction of serum cholesterol and its mechanism by Lactobacillus plantarum H6 screened from local fermented food products, Food Funct, 11, 1397, 10.1039/C9FO02478F Lew, 2020, Lactobacillus strains alleviated hyperlipidemia and liver steatosis in aging rats via activation of AMPK, Int. J. Mol. Sci, 21, 10.3390/ijms21165872 Song, 2017, Effects of microencapsulated Lactobacillus plantarum LIP-1 on the gut microbiota of hyperlipidaemic rats, Br. J. Nutr., 118, 481, 10.1017/S0007114517002380 Zheng, 2020, Probiotic characteristics of Lactobacillus plantarum E680 and its effect on hypercholesterolemic mice, BMC Microbiol, 20, 239, 10.1186/s12866-020-01922-4 Mills, 2020, The global epidemiology of hypertension, Nat. Rev. Nephrol., 16, 223, 10.1038/s41581-019-0244-2 Vaes, 2015, The correlation between blood pressure and kidney function decline in older people: a registry-based cohort study, BMJ Open, 5, 10.1136/bmjopen-2015-007571 Liu, 2017, The probiotic role of Lactobacillus plantarum in reducing risks associated with cardiovascular disease, Int. J. Food. Sci. Tech., 52, 127, 10.1111/ijfs.13234 Liu, 2016, Effects of Lactobacillus plantarum TWK10-fermented soymilk on deoxycorticosterone acetate-salt-induced hypertension and associated dementia in rats, Nutrients, 8, 10.3390/nu8050260 Costabile, 2017, An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults, PLoS One, 12, 10.1371/journal.pone.0187964 Keleszade, 2022, The cholesterol lowering efficacy of Lactobacillus plantarum ECGC 13110402 in hypercholesterolemic adults: a double-blind, randomized, placebo controlled, pilot human intervention study, J. Funct. Foods, 89, 10.1016/j.jff.2022.104939 Tong, 2021, In vitro and in vivo antihypertensive and antioxidant activities of fermented roots of Allium hookeri, Chin. Herb. Med., 13, 541, 10.1016/j.chmed.2021.08.003 Derosa, 2020, Evaluation in patients with high normal blood pressure of a supplement containing arginine, Lactobacillus Plantarum Lp-LDL, coenzime Q10 and vitamin B1: a pilot study, J. Food. Nutr. Res-Slov, 8, 273, 10.12691/jfnr-8-6-5 Chen, 2018, Production and fermentation characteristics of angiotensin-I-converting enzyme inhibitory peptides of goat milk fermented by a novel wild Lactobacillus plantarum 69, LWT-Food Sci. Technol, 91, 532, 10.1016/j.lwt.2018.02.002 Chundakkattumalayil, 2021, Biotechnology, Health endorsing potential of Lactobacillus plantarum MBTU-HK1 and MBTU-HT of Honeybee, gut origin, J. Appl. Biol. Biotech, 9, 6 Fujita, 2017, Improving anti-hyperglycemic and anti-hypertensive properties of camu-camu (Myriciaria dubia Mc. Vaugh) using lactic acid bacterial fermentation, Process Biochem, 59, 133, 10.1016/j.procbio.2017.05.017 Hussin, 2020, Potentiality of self-cloned Lactobacillus plantarum Taj-Apis362 for enhancing GABA production in yogurt under glucose induction: optimization and its cardiovascular effect on spontaneous hypertensive rats, Foods, 9, 10.3390/foods9121826 Saputri, 2018, Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model, J. Int. Med. Res, 46, 5004, 10.1177/0300060518788994 Toshimitsu, 2020, Effects of 12-week ingestion of yogurt containing Lactobacillus plantarum OLL2712 on glucose metabolism and chronic inflammation in prediabetic adults: a randomized placebo-controlled trial, Nutrients, 12, 10.3390/nu12020374 Uchinaka, 2018, Anti-inflammatory effects of heat-killed Lactobacillus plantarum L-137 on cardiac and adipose tissue in rats with metabolic syndrome, Sci. Rep., 8, 8156, 10.1038/s41598-018-26588-x Antza, 2018, Gut microbiota in kidney disease and hypertension, Pharmacol. Res., 130, 198, 10.1016/j.phrs.2018.02.028 Kang, 2018, Gut microbiota and hypertension: From pathogenesis to new therapeutic strategies, Clin. Res. Hepatol. Gastroenterol., 42, 110, 10.1016/j.clinre.2017.09.006 Martin, 2014, Dyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis, Circulation, 129, 77, 10.1161/CIRCULATIONAHA.113.003625 Hassan, 2019, Updates in understanding the hypocholesterolemia effect of probiotics on atherosclerosis, Appl. Microbiol. Biotechnol., 103, 5993, 10.1007/s00253-019-09927-4 Richardson, 2015, Technology, opportunities for product innovation using authorised European Union health claims, Int. J. Food Sci. Technol, 50, 3, 10.1111/ijfs.12574 Qu, 2020, Reduction of serum cholesterol and its mechanism by Lactobacillus plantarum H6 screened from local fermented food products, Food Funct, 11, 1397, 10.1039/C9FO02478F Hofeld, 2021, Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation, Sci. Rep., 11, 3972, 10.1038/s41598-021-83252-7 Malik, 2018, Lactobacillus plantarum 299v Supplementation improves vascular endothelial function and reduces inflammatory biomarkers in men with stable coronary artery disease, Circ. Res., 123, 1091, 10.1161/CIRCRESAHA.118.313565 Hijová, 2017, Ability of Lactobacillus plantarum LS/07 to modify intestinal enzymes activity in chronic diseases prevention, Acta Biochim. Pol., 64, 113, 10.18388/abp.2016_1308 Hassan, 2020, Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE-/- mice through modulation of proinflammatory cytokines and oxidative stress, Appl. Microbiol. Biotechnol., 104, 6337, 10.1007/s00253-020-10693-x Qiu, 2018, Lactobacillus plantarum ZDY04 exhibits a strain-specific property of lowering TMAO via the modulation of gut microbiota in mice, Food Funct, 9, 4299, 10.1039/C8FO00349A Adler-Nissen, 1994, Aeration-controlled formation of acetic acid in heterolactic fermentations, J. Ind. Microbiol., 13, 335, 10.1007/BF01577216 Chiş, 2020, Quinoa sourdough fermented with Lactobacillus plantarum ATCC 8014 designed for gluten-free muffins—a powerful tool to enhance bioactive compounds, Appl. Sci., 10, 7140, 10.3390/app10207140 Park, 2019, Suitability of Lactobacillus plantarum SPC-SNU 72-2 as a probiotic starter for sourdough fermentation, J. Microbiol. Biotechnol, 29, 1729, 10.4014/jmb.1907.07039 Wu, 2019, Research progress on physiological characteristics and probiotic functions of Lactobacillus plantarum, Food and Fermentation Industries, 45, 1 Hütt, 2015, Impact of probiotic Lactobacillus plantarum TENSIA in different dairy products on anthropometric and blood biochemical indices of healthy adults, Benefic. Microbes., 6, 233, 10.3920/BM2014.0035 Liu, 2015, Antihypertensive effect of a combination of uracil and glycerol derived from Lactobacillus plantarum strain TWK10-fermented soy milk, J. Agric. Food Chem, 63, 7333, 10.1021/acs.jafc.5b01649 Abdelazez, 2018, Potential benefits of Lactobacillus plantarum as probiotic and its advantages in human health and industrial applications: a review, Adv. Exp. Med. Biol Behera, 2018, Lactobacillus plantarum with functional properties: An approach to increase safety and shelf-life of fermented foods, BioMed Res. Int., 2018, 9361614, 10.1155/2018/9361614 Nordström, 2021, Lactiplantibacillus plantarum 299v (LP299V(®)): three decades of research, Benef. Microbes., 12, 441, 10.3920/BM2020.0191 Krasaekoopt, 2014, Effect of addition of inulin and galactooligosaccharide on the survival of microencapsulated probiotics in alginate beads coated with chitosan in simulated digestive system, yogurt and fruit juice, LWT-Food Sci. Technol, 57, 761, 10.1016/j.lwt.2014.01.037 Rahayu, 2021, Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults, World J. Gastroenterol, 27, 107, 10.3748/wjg.v27.i1.107 Jiang, 2019 Ma, 2020 Xu, 2021, Preparation of Bifidobacterium lactis Probio-M8 microcapsules by spray freeze drying technology, Chinese Institute of Food Science and Technology, 21, 197 Liu, 2020, Preparation and characterization of Lactobacillus plantarum microcapsules by compounding and multi-layer encapsulation, Sci. Technol, Food Ind, 41, 12 Guo, 2021, Preparation of Bifidobacterium lactis Probio-M8 microcapsules by vacuum low-temperature spray drying, Chinese Institute of Food Science and Technology, 21, 164 Yoha, 2021, 3D printing of encapsulated probiotics: Effect of different post-processing methods on the stability of Lactiplantibacillus plantarum (NCIM 2083) under static in vitro digestion conditions and during storage, LWT-Food Sci. Technol, 146, 10.1016/j.lwt.2021.111461 O'Morain, 2021, The Lab4P consortium of probiotics attenuates atherosclerosis in LDL receptor deficient mice fed a high fat diet and causes plaque stabilization by inhibiting inflammation and several pro-atherogenic processes, Mol. Nutr. Food Res., 65, 10.1002/mnfr.202100214 Michael, 2020, A randomised controlled study shows supplementation of overweight and obese adults with Lactobacilli and Bifidobacteria reduces bodyweight and improves well-being, Sci. Rep., 10, 4183, 10.1038/s41598-020-60991-7 Long, 2020, Lactobacillus plantarum KFY04 prevents obesity in mice through the PPAR pathway and alleviates oxidative damage and inflammation, Food Funct, 11, 5460, 10.1039/D0FO00519C Gan, 2020, Regulating effect of Lactobacillus plantarum CQPC03 on lipid metabolism in high-fat diet-induced obesity in mice, J. Food Biochem, 44, 10.1111/jfbc.13495 Cao, 2019, Ameliorative effect of Lactobacillus plantarum WW-fermented soy extract on rat fatty liver via the PPAR signaling pathway, J. Funct. Foods, 60, 10.1016/j.jff.2019.103439 Nallala, 2019, Hypocholesterolaemic action of Lactobacillus plantarum VJC38 in rats fed a cholesterol-enriched diet, Ann. Microbiol., 69, 369, 10.1007/s13213-018-1427-y Xia, 2020, Purification and characterization of angiotensin-I-converting enzyme inhibitory peptides isolated from whey proteins of milk fermented with Lactobacillus plantarum QS670, J. Dairy Sci, 103, 4919, 10.3168/jds.2019-17594 Landry, 2021, Viability and in vivo hypocholesterolemic effect of Lactobacillus plantarum 29V in local honey, J. Adv. Biol. Biotechnol, 24 Miraghajani, 2019, Probiotic soymilk consumption and renal function among type 2 diabetic patients with nephropathy: a randomized controlled clinical trial, Probiotics Antimicrob, Proteins, 11, 124 Xu, 2021, Adjunctive treatment with probiotics partially alleviates symptoms and reduces inflammation in patients with irritable bowel syndrome, Eur. J. Nutr., 60, 2553, 10.1007/s00394-020-02437-4 Lew, 2019, Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: a randomized, double-blind, placebo-controlled study, Clin. Nutr., 38, 2053, 10.1016/j.clnu.2018.09.010 Sun, 2019, Research on the functionality and stability of Lactobacillus plantarum live bacteria tablet products, Sci. Technol. Food Ind, 40, 309 Jiang, 2021 Axling, 2021, The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: a randomized clinical trial, Acta Obstet. Gynecol. Scand., 100, 1602, 10.1111/aogs.14153