Modulation of tumor necrosis factor receptors 1 and 2 in chronic hepatitis B and C: The differences and implications in pathogenesis

Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J Exp Med 175:323–329;1992.

Aiyama T, Yoshioka K, Okumura A, Takayanagi M, Iwata K, Ishikawa T, Kakumu S. Hypervariable region sequence in cryoglobulin-associated hepatitis C virus in sera of patients with chronic hepatitis C: Relationship to antibody response against hypervariable region genome. Hepatology 24:1346–1350;1996.

Baeuerle PA, Baltimore D. NF-κB: Ten years after. Cell 87:13–20;1996.

Barnes PJ, Karin M. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066–1071;1997.

Bazzoni E, Beutter B. The tumor necrosis factor ligand and receptor families. N Engl J Med 334:1717–1725;1996.

Beg AA, Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274:782–784;1996.

Chen CM, You LR, Hwang LH, Lee YH. Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-β receptor modulates the signal pathway of the lymphotoxin-β receptor. J Virol 71:9417–9426;1997.

Chisari F. Cytotoxic T cell and viral hepatitis. J Clin Invest 99:1472–1477;1997.

Chu CM, Sheen IS, Yeh CT, Hsieh SY, Tsai SL, Liaw YF. Serum levels of interferon-α and -γ in acute and chronic hepatitis B virus infection. Dig Dis Sci 40:2107–2112;1995.

Czaja MJ, Xu J, Alt E. Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor. Gastroenterology 108:1849–1854;1995.

Fang JW, Shen WW, Meager A, Lau JY. Activation of the tumor necrosis factor-alpha system in the liver in chronic hepatitis B virus infection. Am J Gastroenterol 91:748–753;1996.

Fukuda R, Satoh S, Nguyen XT, Uchida Y, Kohge N, Akagi S, Ikeda S, Watanabe M, Fukumoto S. Expression rate of cytokine mRNA in the liver of chronic hepatitis C: Comparison with chronic hepatitis B. J Gastroenterol 30:41–47;1995.

Haridas V, Darnay BG, Natarajan K, Heller R, Aggarwal BB. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation. J Immunol 160:3152–3162;1998.

Higuchi M, Aggarwal BB. Differential roles of two types of TNF receptor in TNF-induced cytotoxicity, DNA fragmentation, and differentiation. J Immunol 152:4017–4025;1994.

Horn TL, O'Brien TD, Schook LB, Rutherford MS. Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression. Toxicol Sci 54:262–273;2000.

Itoh Y, Okanoue T, Ohnishi N, Sakamoto M, Nishioji K, Nakagawa Y, Minami M, Murakami Y, Kashima K. Serum levels of soluble tumor necrosis factor receptors and effects of interferon therapy in patients with chronic hepatitis C virus infection. Am J Gastroenterol 94:1332–1340;1999.

Kallinowski B, Haseroth K, Marinos G, Hanck C, Stremmel W, Theilmann L, Singer MV, Rossol S. Induction of tumour necrosis factor (TNF) receptor type p55 and p75 in patients with chronic hepatitis C virus (HCV) infection. Clin Exp Immunol 111:269–277;1998.

Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J. Formulation and application of numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431–435;1981.

Lau JY, Davis GL, Kniffen J, Qian KP, Urdea MS, Chan CS, Mizokami M, Neuwald PD, Wilber JC. Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 341:1501–1504;1993.

Löhr HF, Elste C, Dienes HP, Michel G, Braun HB, Meyer zum Buschenfelde KH, Gerken G. The quantitative humoral immune response to the hepatitis C virus is correlated with disease activity and response to interferon-alpha. J Hepatol 25:292–300;1996.

Marinos G, Naoumov NV, Rossol S, Torre F, Wong PY, Gallati H, Portmann B, Williams R. Tumor necrosis factor receptors in patients with chronic hepatitis B virus infection. Gastroenterology 108:1453–1463;1995.

Matsumoto M, Hsieh TY, Zhu N, VanArsdale T, Hwang SB, Jeng KS, Gorbalenya AE, Lo SY, Ou JH, Ware CF, Lai MM. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol 71:1301–1309;1997.

Milich DR, Jones JE, Hughes JL, Price J, Raney AK, McLachlan A. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci USA 87:6599–6603;1990.

Minutello MA, Pileri P, Unutmaz D, Censini S, Kuo G, Houghton M, Brunetto MR, Bonino F, Abrignani S. Compartmentalization of T lymphocytes to the site of disease: Intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C. J Exp Med 178:17–25;1993.

Nelson DR, Lim HL, Marousis CG, Fang JW, Davis GL, Shen L, Urdea MS, Kolberg JA, Lau JY. Activation of tumor necrosis factor-alpha system in chronic hepatitis C virus infection. Dig Dis Sci 42:2487–2494;1997.

Rosenfeld ME, Prichard L, Shiojiri N, Fausto N. Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice. Am J Pathol 156:997–1007;2000.

Shirai M, Arichi T, Nishioka M, Nomura T, Ikeda K, Kawanishi K, Engelhard VH, Feinstone SM, Berzofsky JA. CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1. J Immunol 154:2733–2742;1995.

Stevens CE, Beasley RP, Tsui J, Lee W. Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med 292;771–774;1975.

Tai DI, Tsai SL, Chen YM, Chuang YL, Peng CY, Sheen IS, Yeh CT, Chang KS, Huang SN, Kuo GC, Liaw YF. Activation of nuclear factor kappaB in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis. Hepatology 31:656–664;2000.

Tartaglia LA, Goeddel DV. Two TNF receptors. Immunol Today 13:151–153;1992.

Tartaglia LA, Rothe M, Hu YF, Goeddel DV. Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor. Cell 73:213–216;1993.

Tsai SL, Liaw YF, Chen MH, Huang CY, Kuo GC. Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity. Hepatology 25:449–458;1997.

Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787–789;1996.

VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF. Lymphotoxin-β receptor signaling complex: Role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor κB. Proc Natl Acad Sci USA 94:2460–2465;1997.

Walker CM. Cytotoxic T-lymphocyte response to the hepatitis C virus in humans and chimpanzees. Semin Virol 7:13–21;1996.

Weiss G, Umlauft F, Urbanek M, Herold M, Lovevsky M, Offner F, Gordeuk VR. Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infection. J Infect Dis 180:1452–1458;1999.

Weiss T, Grell M, Hessabi B, Bourteel S, Müller G, Scheurich P, Wajant H. Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80. J Immunol 158:2389–2404;1997.

Wong GH, Tartaglia LA, Lee MS, Goeddel DV. Antiviral activity of tumor necrosis factor is signaled through the 55-kDa type I TNF receptor. J Immunol 149:3350–3353;1992.

Yeh CT, Chen TC, Shyu WC, Chien RN, Chu CM, Liaw YF. Quantitative assessment of serum hepatitis B virus DNA: Comparison between two different methods. Hepatol Res 7:159–167;1997.

You LR, Chen CM, Lee YHW. Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha. J Virol 73:1672–1681;1999.

Zhu N, Khoshnan A, Schneider R, Matsumoto M, Dennert G, Ware C, Lai MM. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol 72:3691–3697;1998.