Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects

Antioxidants - Tập 8 Số 12 - Trang 588
Bernardino Clavo1,2,3,4,5, Francisco Rodríguez‐Esparragón3, Delvys Rodríguez‐Abreu6, Gregorio Martı́nez-Sánchez7, Pedro Llontop8, David Aguiar9, Leandro Fernández‐Pérez5, Norberto Santana-Rodríguez10,11,5
1Chronic Pain Unit, Dr. Negrín University Hospital, 35019 Las Palmas de Gran Canaria, Spain
2Radiation Oncology Department, Dr. Negrín University Hospital, 35019 Las Palmas de Gran Canaria, Spain
3Research Unit, Dr. Negrín University Hospital, 35019 Las Palmas de Gran Canaria, Spain
4Spanish Group of Clinical Research in Radiation Oncology (GICOR), 28290 Madrid, Spain
5Universitary Institute for Research in Biomedicine and Health (IUIBS), Molecular and Translational Pharmacology Group, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain
6Medical Oncology Department, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain
7Scientific Advisor, Freelance, 60126 Ancona, Italy
8Experimental Medicine and Surgery Unit of Hospital Gregorio Marañon and the Health Research Institute of Hospital Gregorio Marañon (IiSGM), 28007 Madrid, Spain
9Medical Oncology Department, Dr. Negrín University Hospital, 35019 Las Palmas de Gran Canaria, Spain
10College of Medicine, Department of Surgery, Alfaisal University, 11533 Riyadh, Saudi Arabia
11Thoracic Surgery, Department of Surgery, King Faisal Specialist Hospital and Research Center, 12713 Riyadh, Saudi Arabia

Tóm tắt

(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an intracellular increase of free radicals. However, free radicals can also increase in healthy cells and lead to oxidative stress, resulting in further damage to healthy tissues. Approaches to prevent or treat many of these side effects are limited. Ozone therapy can induce a controlled oxidative stress able to stimulate an adaptive antioxidant response in healthy tissue. This review describes the studies using ozone therapy to prevent and/or treat chemotherapy-induced toxicity, and how its effect is linked to a modification of free radicals and antioxidants. (2) Methods: This review encompasses a total of 13 peer-reviewed original articles (most of them with assessment of oxidative stress parameters) and some related works. It is mainly focused on four drugs: Cisplatin, Methotrexate, Doxorubicin, and Bleomycin. (3) Results: In experimental models and the few existing clinical studies, modulation of free radicals and antioxidants by ozone therapy was associated with decreased chemotherapy-induced toxicity. (4) Conclusions: The potential role of ozone therapy in the management of chemotherapy-induced toxicity merits further research. Randomized controlled trials are ongoing.

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