Modeling human colon cancer in rodents using a food‐borne carcinogen, PhIP

Cancer Science - Tập 96 Số 10 - Trang 627-636 - 2005
Hitoshi Nakagama1, Masako Nakanishi2, Masako Ochiai2
1Biochemistry Division, National Cancer Center Research Institute, 1-1 Tsukiji, 5-chome, Chuo-ku, Tokyo 104-0045, Japan. [email protected]
2Biochemistry Division, National Cancer Center Research Institute,1‐1 Tsukiji, 5‐chome, Chuo‐ku, Tokyo 104‐0045, Japan

Tóm tắt

Animal models provide researchers with powerful tools to elucidate multistage mechanisms for cancer development and to gain further insights into the biological roles of various cancer‐related genes in in vivo situations. As for colon cancer models in rodents, Apc‐disrupted mice, including ApcMin, have been one of the most widely utilized animal models to dissect the molecular events implicated in the development of intestinal tumors. In rats, several models have been established using chemical carcinogens, including azoxymethane and 2‐amino‐1‐methyl‐6‐phenylimidazo‐ [4,5‐b]pyridine (PhIP). The former is a representative colon carcinogenic alkylating agent, and the latter a heterocyclic amine produced while cooking meat and fish, which people are exposed to in ordinary life. It is of great importance to note that PhIP preferentially targets the colon and prostate gland in male rats, and the mammary glands in female rats. Cancers in these three organs are common in Western countries and are currently increasing in Japan, where modern dietary habits are rapidly becoming more like those of the West. In the present article, the history of PhIP‐induced colon cancer models in rodents, activation/detoxification mechanisms of PhIP with regard to the formation of PhIP‐DNA adducts, mechanistic approaches to dissect the molecular events involved in the development of colon cancer by PhIP, and epidemiological evidence of human exposure to PhIP are overviewed. The induction of Paneth cell maturation/differentiation in PhIP‐induced colon cancers, genetic traits affecting susceptibility to colon carcinogenesis, and the biological relevance of colon cancer models in rodents to studying human colon carcinogenesis are also discussed. (Cancer Sci 2005; 96: 627 – 633)

Từ khóa


Tài liệu tham khảo

10.1056/NEJM200007133430201

10.1093/jnci/66.6.1192

10.1038/nature01322

10.1021/jf048633a

10.1016/S0027-5107(99)00196-7

10.1093/carcin/21.3.387

10.1093/carcin/7.7.1081

10.1016/S0304-3835(77)80025-6

10.1111/j.1349-7006.2004.tb03205.x

10.1093/carcin/20.3.353

10.1002/em.10070

10.1093/carcin/18.10.1931

10.1016/j.jchromb.2003.12.029

10.1111/j.1349-7006.1989.tb01644.x

10.1021/tx00029a016

10.1016/S0378-4274(98)00366-X

10.1021/tx00042a004

Dingley KH, 1999, DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary‐relevant dose of 2‐amino‐1‐methyl‐6‐phenylimidazo‐[4,5‐b]pyridine, Cancer Epidemiol Biomarkers Prev, 8, 507

10.1093/carcin/17.4.617

10.1016/S1383-5718(97)00146-0

10.1016/S0027-5107(00)00058-0

10.1093/carcin/18.4.745

10.1093/carcin/21.11.2049

10.1093/mutage/13.6.601

10.1016/S1383-5718(03)00134-7

10.1093/carcin/12.8.1503

10.1093/carcin/bgh268

10.1093/carcin/14.12.2553

10.1093/carcin/23.1.197

10.2307/3432152

10.1111/j.1349-7006.1996.tb03105.x

10.1093/carcin/15.11.2429

10.1093/carcin/18.10.1937

10.1111/j.1349-7006.2000.tb01015.x

10.1016/S0027-5107(02)00160-4

10.1093/carcin/bgh292

10.1073/pnas.92.3.910

Dashwood RH, 1998, High frequency of beta‐catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat, Cancer Res, 58, 1127

10.1016/S0002-9440(10)63517-1

10.1126/science.275.5307.1787

10.1016/S0027-5107(99)00154-2

Toyota M, 1996, Genetic alterations in rat colon tumors induced by heterocyclic amines, Cancer, 77, 1593, 10.1002/(SICI)1097-0142(19960415)77:8+<1593::AID-CNCR2>3.0.CO;2-F

10.1111/j.1349-7006.1994.tb02388.x

10.1002/(SICI)1098-2744(199712)20:4<348::AID-MC4>3.0.CO;2-F

10.1016/S0027-5107(97)00039-0

10.1002/mc.2940090203

10.1073/pnas.081082898

10.1016/S0027-5107(02)00157-4

10.1093/carcin/bgh155

Notterman DA, 2001, Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays, Cancer Res, 61, 3124

Buckhaults P, 2001, Secreted and cell surface genes expressed in benign and malignant colorectal tumors, Cancer Res, 61, 6996

National Institutes of Health. SAGE [Internet document]. Available from URL:http://ncbi.nim.nih.gov/projects/geo/gds/gds_browse.cgi?gds=550

10.1038/ncb1240

10.1016/0304-3835(87)90157-1

Yamada Y, 2001, Sequential analysis of morphological and biological properties of beta‐catenin‐accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis, Cancer Res, 61, 1874

Caderni G, 2003, Identification of mucin‐depleted foci in the unsectioned colon of azoxymethane‐treated rats: correlation with carcinogenesis, Cancer Res, 63, 2388

10.1158/0008-5472.121.65.1

10.1016/j.canlet.2004.10.026

10.1093/carcin/17.1.95

10.1093/carcin/20.6.1063

Sinha R, 1999, Well‐done, grilled red meat increases the risk of colorectal adenomas, Cancer Res, 59, 4320

10.1016/S0304-3835(99)00123-8

10.1093/jnci/91.23.2038

10.1001/jama.293.2.172

Hasegawa R, 1995, Increased risk of mammary carcinoma development following transplacental and trans‐breast milk exposure to a food‐derived carcinogen, 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), in Sprague‐Dawley rats, Cancer Res, 55, 4333

10.1016/S0304-3835(99)00151-2

10.1093/toxsci/kfh104

Thông tin
Thông tin xuất bản

Cancer Science

Tập 96 Số 10

627-636

Thông tin tác giả