Model of mammalian cell reproductive death II. Comparison with experimental data and discussion

Biophysik - Tập 32 - Trang 295-310 - 1993
G. M. Obaturov1, A. S. Filimonov1, V. V. Moiseenko1
1Medical Radiological Research Centre, Russian Medical Science Academy, Obninsk, Russia

Tóm tắt

A general equation for mammalian cell survival has been derived in the previous paper. This paper presents the results of comparison of theoretical evaluations with survival data available from the literature, including different cell lines, variations in linear energy transfer, dose rate and dose fractionation effects and the effects of ultrasoft X-rays and superheavy ions. Merits and demerits of the model are considered in comparison with other models of radiation-induced killing of mammalian cells published in the literature.

Tài liệu tham khảo

Barsukov VS, Malinovsky OV (1973) Quantitative description of cell radiation inactivation process (in Russian). I. Major premises. Lethal lesion formation. Cytologiia 15:1152–1159

Blair H (1960) Theory of information in biology (in Russian). Izd Inostrannaya literatura, Moscow, pp 325–333

Cox R, Masson WK (1979) Mutation and inactivation of cultured mammalian cells exposed to beams of accelerated heavy ions. III. Human diploid fibroblasts. Int J Radiat Biol 36:149–160

Cox R, Thacker J, Goodhead DT (1977) Inactivation and mutation of cultured mammalian cells by aluminium characteristic ultrasoft X-rays. II. Dose-responses of Chinese hamster and human diploid cells to aluminium X-rays and radiations of different LET. Int J Radiat Biol 31:561–576

Curtis SB (1983) Ideas on the unification of radiobiological theories. Radiat Protect Rep EUR 8395:527–536

Davidson RO (1960) Biological investigations of gamma-irradiation in humans (in Russian). In: Popova MF (ed) Izd Atomizdat, Moscow, pp 283–284

Goodhead DT (1980) Models of radiation inactivation and mutagenesis. In: Meyn A, Withers R (eds) Radiation biology and cancer research. Raven, New York, pp 231–247

Goodhead DT, Cox R, Thacker J (1980) Do ultrasoft X-rays produce lesions characteristic of high LET or low LET, or neither? Proceedings of Seventh Symposium on Microdosimetry, 8–12 September, Oxford. Commission of the European Communities, Luxembourg, V. II pp 929–939

Hethcole HW, McLarty JW, Thames HD (1976) Radiat Res 67:387–407

Moiseenko VV, Obaturov GM (1989) Systemic model of mammalian cell reproductive death. Comparison with experimental data. Biological meaning of model parameters (in Russian). Radiobiologiia 29:305–309

Obaturov GM, Alexandrov ID, Alexandrova MV (1989) On the molecular-cytogenetic mechanism of lethal chromosome aberration formation (in Russian). Radiobiol Inf Bull AMS of USSR, Moscow, pp 27–28

Obaturov GM, Filimonov AS (1989) Systemic model of mammalian cell reproductive death: superheavy ion action. In: Neutron and heavy charged particles in biology and medicine. RIMR AMS of USSR, Obninsk, pp 41–44

Regel K (1984) Certain patterns of DNA double-strand breaks in membrane attached super-structure units seem to cause mammalian cell death. Stud Biophys 103:179–194

Regel K, Gunther K, Kampf G (1979) Some conclusions as to the in vivo organization of DNA in eukaryotic cells following from sedimentation studies after irradiation. Stud Biophys 76:11–12

Schäfer M, Facius R, Baltschukat U, Bücker H (1980) Contribution of ion kill and ofd-electrons to inactivation cross sections ofBacillus subtilis spores irradiated with very heavy ions. Proceedings of Seventh Symposium on Microdosimetry, 8–12 September, Oxford. Commission of the European Communities, Luxembourg, 1331–1340

Thacker J, Stretch A, Stephens MA (1979) Mutation and inactivation of cultured mammalian cells exposed to beams of accelerated ion. II. Chinese hamster V-79 cells. Int J Radiat Biol 36:2

Yang TC Graise LM, Mei MT, Tobias CA (1986) Adv Space Res 6:137–147