Mitogen‐activated protein kinase/extracellular regulated kinase signalling and memory stabilization: a review

Genes, Brain and Behavior - Tập 5 Số s2 - Trang 61-72 - 2006
Sabrina Davis1, Serge Laroche1
1Laboratoire de Neurobiologie de l’Apprentissage, de la Mémoire et de la Communication CNRS, UMR 8620, Université Paris-Sud, Orsay, France

Tóm tắt

The function of mitogen‐activated protein kinase (MAPK) in neurons has been the subject of considerable scrunity of late, and recent studies have given new insights into how this signalling cascade can regulate gene expression following cell‐surface receptor activation. At the same time, a wealth of experimental data has demonstrated that the MAPK cascade is critically involved in the mechanisms underlying the type of enduring modification of neural networks required for the stability of memories, emphasizing the high level of interest in this signalling molecule. In this review, we briefly outline the main molecular events and mechanisms of the regulation of the MAPK cascade leading to transcriptional activation and summarize recent advances in our understanding of the functional role of this molecular signalling cascade in regulating brain plasticity, memory consolidation and memory reconsolidation.

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Tài liệu tham khảo

10.1146/annurev.pharmtox.42.082701.145401

10.1073/pnas.95.13.7475

10.1038/2836

10.1126/science.1715095

10.1523/JNEUROSCI.20-18-07017.2000

10.1016/S0092-8674(00)81816-4

10.1038/361031a0

10.1523/JNEUROSCI.19-09-03535.1999

10.1091/mbc.2.5.357

10.1098/rstb.2002.1224

10.1038/36849

10.1016/S0021-9258(17)42250-2

10.1126/science.281.5382.1505

10.1523/JNEUROSCI.19-18-07983.1999

10.1016/S0896-6273(00)80471-7

Chui V.K., 2002, Ras signalling on the endoplasmic reticulum and the Golgi, Nat Cell Biol, 4, 343, 10.1038/ncb783

10.1074/jbc.270.25.14843

10.1152/jn.1999.81.1.103

10.1083/jcb.94.2.287

10.1038/nature711

10.1038/86898

10.1037/0033-2909.96.3.518

10.1523/JNEUROSCI.20-12-04563.2000

10.1523/JNEUROSCI.23-03-00748.2003

10.1038/346719a0

10.1016/j.neuron.2004.09.003

10.1111/j.1460-9568.2004.03824.x

10.1074/jbc.271.40.24329

10.1074/jbc.272.31.19103

10.1016/S0021-9258(17)40710-1

10.1038/376524a0

10.1038/381706a0

10.1016/S0896-6273(00)80395-5

10.1111/j.1471-4159.1993.tb09796.x

10.1523/JNEUROSCI.5407-03.2004

10.1016/S0028-3908(01)00096-X

10.1046/j.1460-9568.2003.02694.x

10.1016/0092-8674(89)90013-5

10.1037/0735-7044.116.3.455

10.1038/85109

10.1016/S0896-6273(00)80737-0

10.1101/lm.48502

10.1210/me.13.12.2039

Huang Y.Y., 2000, Both protein kinase A and mitogen‐activated protein kinase are required in the amygdala for macromolecular synthesis‐dependent late phase of long‐term potentiation, J Neurosci, 20, 6317, 10.1523/JNEUROSCI.20-17-06317.2000

10.1016/S0896-6273(00)80120-8

10.1016/S0896-6273(00)80602-9

Jones M.W., 1999, Molecular mechanisms of long‐term potentiation in the insular cortex in vivo, J Neurosci, 19, RC36, 10.1523/JNEUROSCI.19-21-j0002.1999

Kang H., 1995, A requirement for local protein synthesis in neurotrophin‐induced hippocampal synaptic plasticity, Science, 267, 1402

10.1016/S0896-6273(00)80378-5

10.1523/JNEUROSCI.20-09-03057.2000

10.1074/jbc.274.19.13498

10.1016/S0092-8674(04)00115-1

10.1523/JNEUROSCI.23-12-05354.2003

10.1523/JNEUROSCI.23-04-01119.2003

10.1016/S0896-6273(00)81008-9

10.1128/MCB.10.6.2645

10.1038/364249a0

10.1523/JNEUROSCI.22-22-09721.2002

10.1016/S0896-6273(03)00645-7

10.1126/science.1095760

10.1016/S0065-230X(08)60765-4

10.1016/S0896-6273(00)80245-7

Lu K.‐T., 2001, Mitogen‐activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear‐potentiated startle, J Neurosci, 21, RC162, 10.1523/JNEUROSCI.21-16-j0005.2001

10.1152/physrev.00014.2003

10.1523/JNEUROSCI.20-07-02504.2000

10.1074/jbc.272.7.4378

10.1016/0092-8674(95)90401-8

10.1128/MCB.14.9.6107

10.1073/pnas.191152098

10.1016/S0896-6273(02)00716-X

10.1126/science.287.5451.248

10.1073/pnas.87.24.9595

Messaoudi E., 1998, Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus, J Physiol, 79, 496

10.1126/science.160.3827.554

10.1016/S0896-6273(03)00404-5

Murphy L.O., 2002, Molecular interpretation of ERK signal duration by immediate early gene products, Nat Cell Biol, 4, 983, 10.1038/ncb822

10.1046/j.1471-4159.2000.0740192.x

10.1038/sj.bjc.6601488

10.1038/nn771

10.1016/S0896-6273(01)00443-3

10.1242/jcs.107.6.1661

Resh M.D., 1996, Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins, Cell, 8, 403

Roberson E.D., 1999, The mitogen‐activated protein kinase cascade couples PKA and PKC to CREB phosphorylation in area CA1 of hippocampus, J Neurosci, 19, 4337, 10.1523/JNEUROSCI.19-11-04337.1999

10.1016/0896-6273(94)90438-3

Rosenblum K., 2000, ERKI/II regulation by the muscarinic acetylcholine receptor in neurons, J Neurosci, 20, 977, 10.1523/JNEUROSCI.20-03-00977.2000

Rosenblum K., 2002, The role of extracellular regulated kinases I/II in late‐phase long‐term potentiation, J Neurosci, 22, 5432, 10.1523/JNEUROSCI.22-13-05432.2002

10.1038/10067

10.1523/JNEUROSCI.4880-03.2004

10.1523/JNEUROSCI.20-21-08177.2000

Schultz S., 1999, Direct evidence for biphasic cAMP responsive element‐binding protein phosphorylation during long‐term potentiation in the rat dentate gyrus in vivo, J Neurosci, 19, 5683, 10.1523/JNEUROSCI.19-13-05683.1999

10.1101/lm.6.5.478

10.1101/lm.37001

10.1101/lm.51103

10.1002/jnr.20052

10.1126/science.1646483

10.1038/358351a0

10.1016/S0968-0004(99)01383-3

10.1016/S0962-8924(02)02294-8

10.1101/gad.8.21.2527

10.1074/jbc.271.6.3066

10.1016/S0031-9384(00)00225-0

Sweatt J.D., 2001, The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory, J Neurochem, 67, 1, 10.1046/j.1471-4159.2001.00054.x

10.1016/j.conb.2004.04.001

10.1073/pnas.012605299

10.1523/JNEUROSCI.22-06-02054.2002

10.1038/nrn1346

10.1038/384567a0

10.1016/S0896-6273(02)00717-1

10.1016/S0092-8674(00)80184-1

10.1016/S0166-4328(99)00077-7

10.1006/nlme.1999.3913

10.1128/MCB.22.3.916-926.2001

Watanabe A.M., 2000, Coactivation of beta adrenergic and cholinergic receptors enhances the introduction of long‐term potentiation and synergistically activates mitogen‐activated protein kinase in the hippocampal CA1 region, J Neurosci, 20, 5924, 10.1523/JNEUROSCI.20-16-05924.2000

10.1016/S0896-6273(02)00634-7

10.1038/nrn987

10.1038/346696a0

10.1016/S0896-6273(00)81124-1

10.1038/83976

10.1007/BF02253672

10.1074/jbc.273.37.24052

10.1523/JNEUROSCI.22-05-01532.2002

10.1038/33451

Zheng C.F., 1993, Properites of MEKs, the kinases that phosphorylate and activate the extracellular signal‐regulated kinases, J Biol Chem, 268, 933

10.1016/S0092-8674(02)00897-8

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Genes, Brain and Behavior

Tập 5 Số s2

61-72

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