Mitogen-Activated Protein (MAP) Kinases in Plant Metal Stress: Regulation and Responses in Comparison to Other Biotic and Abiotic Stresses
Tóm tắt
Từ khóa
Tài liệu tham khảo
Nriagu, 1988, Quantitative assessment of worldwide contamination of air, water and soils by trace metals, Nature, 333, 134, 10.1038/333134a0
Ruttens, 2011, Short rotation coppice culture of willow and poplar as energy crops on metal contaminated agricultural soils, Int. J. Phytoremediat, 13, 194, 10.1080/15226514.2011.568543
Kirkham, 2006, Cadmium in plants on polluted soils: Effects of soil factors, hyperaccumulation, and amendments, Geoderma, 137, 19, 10.1016/j.geoderma.2006.08.024
Chary, 2008, Assessing risk of heavy metals from consuming food grown on sewage irrigated soils and food chain transfer, Ecotoxicol. Environ. Saf, 69, 513, 10.1016/j.ecoenv.2007.04.013
Marschner, H. (1995). Mineral Nutrition of Higher Plants, Academic Press. [2nd ed].
Hirt, H. (2009). Plant Stress Biology: From Genomics to Systems Biology, Wiley-VCH Verlag. [1st ed].
Leonard, 2004, Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses, Mol. Cell. Biochem, 255, 3, 10.1023/B:MCBI.0000007255.72746.a6
Hogervorst, 2007, House dust as possible route of environmental exposure to cadmium and lead in the adult general population, Environ. Res, 103, 30, 10.1016/j.envres.2006.05.009
Nawrot, 2006, Environmental exposure to cadmium and risk of cancer: A prospective population-based study, Lancet Oncol, 7, 119, 10.1016/S1470-2045(06)70545-9
Nawrot, 2010, Cadmium exposure in the population: from risks to measures of prevention, Biometals, 23, 769, 10.1007/s10534-010-9343-z
Thijssen, 2007, Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys, Toxicology, 236, 29, 10.1016/j.tox.2007.03.022
DalCorso, 2008, How plants cope with cadmium: Staking all on metabolism and gene expression, J. Integr. Plant Biol, 50, 1268, 10.1111/j.1744-7909.2008.00737.x
Yruela, 2009, Copper in plants: Acquisition, transport and interactions, Funct. Plant Biol, 36, 409, 10.1071/FP08288
Smeets, 2009, Oxidative stress-related responses at transcriptional and enzymatic levels after exposure to Cd or Cu in a multipollution context, J. Plant Physiol, 166, 1982, 10.1016/j.jplph.2009.06.014
Cuypers, 2011, The cellular redox state as a modulator in cadmium and copper responses in Arabidopsis thaliana seedlings, J. Plant Physiol, 168, 309, 10.1016/j.jplph.2010.07.010
Gupta, D.K.G., and Sandalio, L.M. (2011). Metal Toxicity in Plants: Perception, Signalling and Remediation, Springer-Verlag GmbH. [1st ed].
Gratao, 2005, Making the life of heavy metal-stressed plants a little easier, Funct. Plant Biol, 32, 481, 10.1071/FP05016
Mittler, 2004, Reactive oxygen gene network of plants, Trends Plant Sci, 9, 490, 10.1016/j.tplants.2004.08.009
Pitzschke, 2006, Reactive oxygen species signaling in plants, Antioxid. Redox Sign, 8, 1757, 10.1089/ars.2006.8.1757
Opdenakker, 2012, Exposure of Arabidopsis thaliana to Cd or Cu excess leads to oxidative stress mediated alterations in MAPKinase transcript levels, Environ. Exp. Bot, 83, 53, 10.1016/j.envexpbot.2012.04.003
Kalbina, 2006, The role of NADPH oxidase and MAP kinase phosphatase in UV-B-dependent gene expression in Arabidopsis, Plant Cell Environ, 29, 1783, 10.1111/j.1365-3040.2006.01555.x
Miller, 2010, Reactive oxygen species homeostasis and signalling during drought and salinity stresses, Plant Cell Environ, 33, 453, 10.1111/j.1365-3040.2009.02041.x
Vandenabeele, 2004, Catalase deficiency drastically affects gene expression induced by high light in Arabidopsis thaliana, Plant J, 39, 45, 10.1111/j.1365-313X.2004.02105.x
Suzuki, 2006, Reactive oxygen species and temperature stresses: A delicate balance between signaling and destruction, Physiol. Plant, 126, 45, 10.1111/j.0031-9317.2005.00582.x
Torres, 2006, Reactive oxygen species signaling in response to pathogens, Plant Physiol, 141, 373, 10.1104/pp.106.079467
Rogers, 2012, Is there an important role for reactive oxygen species and redox regulation during floral senescence?, Plant Cell Environ, 35, 217, 10.1111/j.1365-3040.2011.02373.x
Bright, 2006, ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis, Plant J, 45, 113, 10.1111/j.1365-313X.2005.02615.x
Locato, 2012, Redox regulation in plant programmed cell death, Plant Cell Environ, 35, 234, 10.1111/j.1365-3040.2011.02387.x
Foreman, 2003, Reactive oxygen species produced by NADPH oxidase regulate plant cell growth, Nature, 422, 442, 10.1038/nature01485
Apel, 2004, Reactive oxygen species: Metabolism, oxidative stress, and signal transduction, Annu. Rev. Plant Biol, 55, 373, 10.1146/annurev.arplant.55.031903.141701
Miller, 2008, Reactive oxygen signaling and abiotic stress, Physiol. Plant, 133, 481, 10.1111/j.1399-3054.2008.01090.x
Quan, 2008, Hydrogen peroxide in plants: A versatile molecule of the reactive oxygen species network, J. Integr. Plant Biol, 50, 2, 10.1111/j.1744-7909.2007.00599.x
Mishra, 2006, Signaling through MAP kinase networks in plants, Arch. Biochem. Biophys, 452, 55, 10.1016/j.abb.2006.05.001
Ichimura, 2002, Mitogen-activated protein kinase cascades in plants: a new nomenclature, Trends Plant Sci, 7, 301, 10.1016/S1360-1385(02)02302-6
Jonak, 2002, Complexity, cross talk and integration of plant MAP kinase signalling, Curr. Opin. Plant Biol, 5, 415, 10.1016/S1369-5266(02)00285-6
Morrison, 2003, Regulation of map kinase signaling modules by scaffold proteins in mammals, Annu. Rev. Cell Dev. Biol, 19, 91, 10.1146/annurev.cellbio.19.111401.091942
Nakagami, 2004, OMTK1, a novel MAPKKK, channels oxidative stress signaling through direct MAPK interaction, J. Biol. Chem, 279, 26959, 10.1074/jbc.M312662200
Bartels, 2010, Emerging functions for plant MAP kinase phosphatases, Trends Plant Sci, 15, 322, 10.1016/j.tplants.2010.04.003
Ulm, 2001, Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis, Gene Dev, 15, 699, 10.1101/gad.192601
Ulm, 2002, Distinct regulation of salinity and genotoxic stress responses by Arabidopsis MAP kinase phosphatase 1, EMBO J, 21, 6483, 10.1093/emboj/cdf646
Anderson, 2011, Arabidopsis MAP kinase phosphatase 1 (AtMKP1) negatively regulates MPK6-mediated PAMP responses and resistance against bacteria, Plant J, 67, 258, 10.1111/j.1365-313X.2011.04588.x
Besteiro, 2011, Arabidopsis MAP kinase phosphatase 1 and its target MAP kinases 3 and 6 antagonistically determine UV-B stress tolerance, independent of the UVR8 photoreceptor pathway, Plant J, 68, 727, 10.1111/j.1365-313X.2011.04725.x
Lee, 2008, Regulation of MAPK phosphatase 1 (AtMKP1) by calmodulin in Arabidopsis, J. Biol. Chem, 283, 23581, 10.1074/jbc.M801549200
Bartels, 2009, MAP kinase phosphatase1 and protein tyrosine phosphatase1 are repressors of salicylic acid synthesis and SNC1-mediated responses in Arabidopsis, Plant Cell, 21, 2884, 10.1105/tpc.109.067678
Lee, 2007, Arabidopsis MAPK phosphatase 2 (MKP2) positively regulates oxidative stress tolerance and inactivates the MPK3 and MPK6 MAPKs, J. Biol. Chem, 282, 25020, 10.1074/jbc.M701888200
Lumbreras, 2010, MAPK phosphatase MKP2 mediates disease responses in Arabidopsis and functionally interacts with MPK3 and MPK6, Plant J, 63, 1017, 10.1111/j.1365-313X.2010.04297.x
Bargmann, 2006, The role of phospholipase D in plant stress responses, Curr. Opin. Plant Biol, 9, 515, 10.1016/j.pbi.2006.07.011
Yu, 2010, Phosphatidic acid mediates salt stress response by regulation of MPK6 in Arabidopsis thaliana, New Phytol, 188, 762, 10.1111/j.1469-8137.2010.03422.x
Anthony, 2004, A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis, EMBO J, 23, 572, 10.1038/sj.emboj.7600068
Rentel, 2004, OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis, Nature, 427, 858, 10.1038/nature02353
Camehl, I., Drzewiecki, C., Vadassery, J., Shahollari, B., Sherameti, I., Forzani, C., Munnik, T., Hirt, H., and Oelmuller, R (2011). The OXI1 kinase pathway mediates Piriformospora indica-induced growth promotion in Arabidopsis. PLoS Pathog, 7.
Anthony, 2006, The Arabidopsis protein kinase PTI1–2 is activated by convergent phosphatidic acid and oxidative stress signaling pathways downstream of PDK1 and OXI1, J. Biol. Chem, 281, 37536, 10.1074/jbc.M607341200
Forzani, 2011, The Arabidopsis protein kinase Pto-interacting 1–4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases, Febs J, 278, 1126, 10.1111/j.1742-4658.2011.08033.x
Moon, 2003, NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants, Proc. Natl. Acad. Sci. USA, 100, 358, 10.1073/pnas.252641899
Zhang, 2006, Diverse signals converge at MAPK cascades in plant, Plant Physiol. Biochem, 44, 274, 10.1016/j.plaphy.2006.06.004
Pitzschke, 2009, Disentangling the Complexity of Mitogen-activated protein kinases and reactive oxygen species signaling, Plant Physiol, 149, 606, 10.1104/pp.108.131557
Zhang, 2001, MAPK cascades in plant defense signaling, Trends Plant Sci, 6, 520, 10.1016/S1360-1385(01)02103-3
Colcombet, 2008, Arabidopsis MAPKs: A complex signalling network involved in multiple biological processes, Biochem. J, 413, 217, 10.1042/BJ20080625
Liu, 2010, Cadmium activates Arabidopsis MPK3 and MPK6 via accumulation of reactive oxygen species, Phytochemistry, 71, 614, 10.1016/j.phytochem.2010.01.005
Rao, 2011, Arsenic stress activates MAP kinase in rice roots and leaves, Arch. Biochem. Biophys, 506, 73, 10.1016/j.abb.2010.11.006
Jonak, 2004, Heavy metal stress. Activation of distinct mitogen-activated protein kinase pathways by copper and cadmium, Plant Physiol, 136, 3276, 10.1104/pp.104.045724
Kovtun, 2000, Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants, Proc. Natl. Acad. Sci. USA, 97, 2940, 10.1073/pnas.97.6.2940
Opdenakker, K (2012). Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium. Arabidopsis thaliana oxi1 and mpk6 knockout seedlings are less sensitive to Cu exposure. Unpublished work.
Roelofs, 2008, Functional ecological genomics to demonstrate general and specific responses to abiotic stress, Funct. Ecol, 22, 8, 10.1111/j.1365-2435.2007.01312.x
Suzuki, 2001, Screening of cadmium-responsive genes in Arabidopsis thaliana, Plant Cell Environ, 24, 1177, 10.1046/j.1365-3040.2001.00773.x
Gupta, 2009, Differential response of arsenic stress in two varieties of Brassica juncea L, Chemosphere, 74, 1201, 10.1016/j.chemosphere.2008.11.023
Agrawal, 2002, Isolation of novel rice (Oryza sativa L.) multiple stress responsive MAP kinase gene, OsMSRMK2, whose mRNA accumulates rapidly in response to environmental cues, Biochem. Bioph. Res. Commun, 294, 1009, 10.1016/S0006-291X(02)00571-5
Agrawal, 2003, Novel rice MAP kinases OsMSRMK3 and OsWJUMK1 involved in encountering diverse environmental stresses and developmental regulation, Biochem. Bioph. Res. Commun, 300, 775, 10.1016/S0006-291X(02)02868-1
Yeh, 2004, Cadmium activates a mitogen-activated protein kinase gene and MBP kinases in rice, Plant Cell Physiol, 45, 1306, 10.1093/pcp/pch135
Yeh, 2003, Copper treatment activates mitogen-activated protein kinase signalling in rice, Physiol. Plant, 119, 392, 10.1034/j.1399-3054.2003.00191.x
Hung, 2005, Reactive oxygen species, calcium and serine/threonine phosphatase are required for copper-induced MAP kinase gene OsMAPK2, expression in rice, Plant Growth Regul, 45, 233, 10.1007/s10725-005-1435-3
Yeh, 2007, Distinct signalling pathways for induction of MAP kinase activities by cadmium and copper in rice roots, J. Exp. Bot, 58, 659, 10.1093/jxb/erl240
Lin, 2005, Zinc induces mitogen-activated protein kinase activation mediated by reactive oxygen species in rice roots, Plant Physiol. Biochem, 43, 963, 10.1016/j.plaphy.2005.10.001
Huang, 2008, ROS and CDPK-like kinase-mediated activation of MAP kinase in rice roots exposed to lead, Chemosphere, 71, 1377, 10.1016/j.chemosphere.2007.11.031
Tsai, 2006, Effects of iron excess on cell viability and mitogen-activated protein kinase activation in rice roots, Physiol. Plant, 127, 583, 10.1111/j.1399-3054.2006.00696.x
Wang, 2010, A novel mitogen-activated protein kinase gene in maize (Zea mays), ZmMPK3, is involved in response to diverse environmental cues, J. Integr. Plant Biol, 52, 442, 10.1111/j.1744-7909.2010.00906.x
Ding, 2009, Hexavalent chromium (VI) stress induces mitogen-activated protein kinase activation mediated by distinct signal molecules in roots of Zea mays L, Environ. Exp. Bot, 67, 328, 10.1016/j.envexpbot.2009.08.007
Ren, 2002, Cell death mediated by MAPK is associated with hydrogen peroxide production in Arabidopsis, J. Biol. Chem, 277, 559, 10.1074/jbc.M109495200
Nakagami, 2006, A mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in Arabidopsis, J. Biol. Chem, 281, 38697, 10.1074/jbc.M605293200
Ichimura, 1998, Isolation of ATMEKK1 (a MAP kinase kinase kinase)—Interacting proteins and analysis of a MAP kinase cascade in Arabidopsis, Biochem. Bioph. Res. Commun, 253, 532, 10.1006/bbrc.1998.9796
Mizoguchi, 1998, Identification of a possible MAP kinase cascade in Arabidopsis thaliana based on pairwise yeast two-hybrid analysis and functional complementation tests of yeast mutants, FEBS Lett, 437, 56, 10.1016/S0014-5793(98)01197-1
Ichimura, 2000, Various abiotic stresses rapidly activate Arabidopsis MAP kinases ATMPK4 and ATMPK6, Plant J, 24, 655, 10.1046/j.1365-313x.2000.00913.x
Huang, 2000, ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation, Plant Physiol, 122, 1301, 10.1104/pp.122.4.1301
Matsuoka, 2002, Activation of AtMEK1, an Arabidopsis mitogen-activated protein kinase kinase, in vitro and in vivo: Analysis of active mutants expressed in E-coli and generation of the active form in stress response in seedlings, Plant J, 29, 637, 10.1046/j.0960-7412.2001.01246.x
Pitzschke, 2009, A major role of the MEKK1-MKK1/2-MPK4 pathway in ROS signalling, Mol. Plant, 2, 120, 10.1093/mp/ssn079
Asai, 2002, MAP kinase signalling cascade in Arabidopsis innate immunity, Nature, 415, 977, 10.1038/415977a
Ding, 2011, Microarray-based analysis of cadmium-responsive microRNAs in rice (Oryza sativa), J. Exp. Bot, 62, 3563, 10.1093/jxb/err046
Kim, 2011, Arabidopsis MKK4 mediates osmotic-stress response via its regulation of MPK3 activity, Biochem. Bioph. Res. Commun, 412, 150, 10.1016/j.bbrc.2011.07.064
Liu, 2007, MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants, Plant Physiol, 143, 661, 10.1104/pp.106.091389
Teige, 2004, The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis, Mol. Cell, 15, 141, 10.1016/j.molcel.2004.06.023
Doczi, 2007, The Arabidopsis mitogen-activated protein kinase kinase MKK3 is upstream of group C mitogen-activated protein kinases and participates in pathogen signaling, Plant Cell, 19, 3266, 10.1105/tpc.106.050039
Takahashi, 2007, The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis, Plant Cell, 19, 805, 10.1105/tpc.106.046581
Takahashi, 2011, Calmodulin-dependent activation of MAP kinase for ROS homeostasis in Arabidopsis, Mol. Cell, 41, 649, 10.1016/j.molcel.2011.02.029
Carbonell, 2007, Diverse stress signals activate the C1 subgroup MAP kinases of Arabidopsis, FEBS Lett, 581, 1834, 10.1016/j.febslet.2007.03.075
Popescu, 2009, MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays, Gene Dev, 23, 80, 10.1101/gad.1740009
Eulgem, 2000, The WRKY superfamily of plant transcription factors, Trends Plant Sci, 5, 199, 10.1016/S1360-1385(00)01600-9
Gadjev, 2006, Transcriptomic footprints disclose specificity of reactive oxygen species signaling in Arabidopsis, Plant Physiol, 141, 436, 10.1104/pp.106.078717
Zhou, 2011, WRKY22 transcription factor mediates dark-induced leaf senescence in Arabidopsis, Mol. Cells, 31, 303, 10.1007/s10059-011-0047-1
Andreasson, 2005, The MAP kinase substrate MKS1 is a regulator of plant defense responses, EMBO J, 24, 2579, 10.1038/sj.emboj.7600737
Zheng, 2006, Arabidopsis WRKY33 transcription factor is required for resistance to necrotrophic fungal pathogens, Plant J, 48, 592, 10.1111/j.1365-313X.2006.02901.x
Li, 2009, Functional analysis of an Arabidopsis transcription factor WRKY25 in heat stress, Plant Cell Rep, 28, 683, 10.1007/s00299-008-0666-y
Jiang, 2009, Functional characterization of Arabidopsis NaCl-inducible WRKY25 and WRKY33 transcription factors in abiotic stresses, Plant Mol. Biol, 69, 91, 10.1007/s11103-008-9408-3
Vanderauwera, 2005, Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis, Plant Physiol, 139, 806, 10.1104/pp.105.065896
Desikan, 2001, Regulation of the Arabidopsis transcriptome by oxidative stress, Plant Physiol, 127, 159, 10.1104/pp.127.1.159
Cheong, 2002, Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormonal responses in Arabidopsis, Plant Physiol, 129, 661, 10.1104/pp.002857
Davletova, 2005, The zinc-finger protein Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis, Plant Physiol, 139, 847, 10.1104/pp.105.068254
Li, 2011, Arabidopsis thaliana WRKY25, WRKY26, and WRKY33 coordinate induction of plant thermotolerance, Planta, 233, 1237, 10.1007/s00425-011-1375-2
Rizhsky, 2004, The zinc finger protein Zat12 is required for cytosolic ascorbate peroxidase 1 expression during oxidative stress in Arabidopsis, J. Biol. Chem, 279, 11736, 10.1074/jbc.M313350200
Davletova, 2005, Cytosolic ascorbate peroxidase 1 is a central component of the reactive oxygen gene network of Arabidopsis, Plant Cell, 17, 268, 10.1105/tpc.104.026971
Vogel, 2005, Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis, Plant J, 41, 195, 10.1111/j.1365-313X.2004.02288.x
Xing, 2007, AtMEK1 mediates stress-induced gene expression of CAT1 catalase by triggering H2O2 production in Arabidopsis, J. Exp. Bot, 58, 2969, 10.1093/jxb/erm144
Xing, 2008, AtMKK1 mediates ABA-induced CAT1 expression and H2O2 production via AtMPK6-coupled signaling in Arabidopsis, Plant J, 54, 440, 10.1111/j.1365-313X.2008.03433.x
Kendrick, 2008, Ethylene signaling: New levels of complexity and regulation, Curr. Opin. Plant Biol, 11, 479, 10.1016/j.pbi.2008.06.011
Wasternack, 2010, Jasmonates: Structural requirements for lipid-derived signals active in plant stress responses and development, ACS Chem. Biol, 5, 63, 10.1021/cb900269u
Liu, 2004, Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis, Plant Cell, 16, 3386, 10.1105/tpc.104.026609
Xu, 2008, Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis, J. Biol. Chem, 283, 26996, 10.1074/jbc.M801392200
Shan, 2012, Comparison of phytohormone signaling mechanisms, Curr. Opin. Plant Biol, 15, 84, 10.1016/j.pbi.2011.09.006
Kieber, 1993, Ctr1, a negative regulator of the ethylene response pathway in Arabidopsis, Encodes a member of the raf family of protein-kinases, Cell, 72, 427, 10.1016/0092-8674(93)90119-B
Novikova, 2000, The effect of ethylene on MAPKinase-like activity in Arabidopsis thaliana, FEBS Lett, 474, 29, 10.1016/S0014-5793(00)01565-9
Ouaked, 2003, A MAPK pathway mediates ethylene signaling in plants, EMBO J, 22, 1282, 10.1093/emboj/cdg131
Yoo, 2008, Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling, Nature, 451, 789, 10.1038/nature06543
Bethke, 2009, Flg22 regulates the release of an ethylene response factor substrate from MAP kinase 6 in Arabidopsis thaliana via ethylene signaling, Proc. Natl. Acad. Sci. USA, 106, 8067, 10.1073/pnas.0810206106
Remans, 2010, Metal-specific and NADPH oxidase dependent changes in lipoxygenase and NADPH oxidase gene expression in Arabidopsis thaliana exposed to cadmium or excess copper, Funct. Plant Biol, 37, 532, 10.1071/FP09194
Opdenakker, K (2012). Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium. MPK6 regulates transcription of lipoxygenases in Arabidopsis thaliana. Unpublished work.
Bell, 1995, A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis, Proc. Natl. Acad. Sci. USA, 92, 8675, 10.1073/pnas.92.19.8675
Petersen, 2000, Arabidopsis MAP kinase 4 negatively regulates systemic acquired resistance, Cell, 103, 1111, 10.1016/S0092-8674(00)00213-0