Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

American Association for the Advancement of Science (AAAS) - Tập 298 Số 5600 - Trang 1911-1912 - 2002
Gary L. Johnson1, Razvan Lapadat1
1Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA

Tóm tắt

Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another. The extracellular signal–regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents. The c-Jun amino-terminal kinases (JNKs) are critical regulators of transcription, and JNK inhibitors may be effective in control of rheumatoid arthritis. The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity.

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Tài liệu tham khảo

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G. L. Johnson R. Lapadat ERK Pathway Science's STKE (Connections Map as seen November 2002) ;CMP_10705.

___ JNK Pathway Science's STKE (Connections Map as seen November 2002) ;CMP_10827.

___ p38 Pathway Science's STKE (Connections Map as seen November 2002) ;CMP_10958.

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10.1038/372739a0

10.1126/science.1067289

10.1016/S0165-6147(00)01865-4

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American Association for the Advancement of Science (AAAS)

Tập 298 Số 5600

1911-1912

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