Mild cognitive impairment in Parkinson's disease is associated with a distributed pattern of brain white matter damage

Human Brain Mapping - Tập 35 Số 5 - Trang 1921-1929 - 2014
Federica Agosta1, Elisa Canu1, Elka Stefanova2, Lidia Sarro3,1, Aleksandra Tomić2, Vladana Marković2, Giancarlo Comi4, Vladimir Kostić2, Massimo Filippi3,1
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
2Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
3Department of Neurology Institute of Experimental Neurology Division of Neuroscience, San Raffaele Scientific Institute Vita‐Salute San Raffaele University Milan Italy
4Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

Tóm tắt

AbstractThis study assesses the patterns of gray matter (GM) and white matter (WM) damage in patients with Parkinson's disease and mild cognitive impairment (PD‐MCI) compared with healthy controls and cognitively unimpaired PD patients (PD‐Cu). Three‐dimensional T1‐weighted and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were obtained from 43 PD patients and 33 healthy controls. Cognition was assessed using a neuropsychological battery. Tract‐based spatial statistics was applied to compare DT MRI indices between groups on a voxel‐by‐voxel basis. Voxel‐based morphometry was performed to assess GM atrophy. Thirty PD patients were classified as MCI. Compared with healthy controls, PD‐Cu and PD‐MCI patients did not have GM atrophy. No region of WM damage was found in PD‐Cu patients when compared with healthy controls. Relative to healthy controls and PD‐Cu patients, PD‐MCI patients showed a distributed pattern of WM abnormalities in the anterior and superior corona radiata, genu, and body of the corpus callosum, and anterior inferior fronto‐occipital, uncinate, and superior longitudinal fasciculi, bilaterally. Subtle cognitive decline in PD is associated with abnormalities of frontal and interhemispheric WM connections, and not with GM atrophy. DT MRI might contribute to the identification of structural changes in PD‐MCI patients prior to the development of dementia. Hum Brain Mapp 35:1921–1929, 2014. © 2013 Wiley Periodicals, Inc.

Từ khóa


Tài liệu tham khảo

Agosta F, 2012, The topography of brain damage at different stages of Parkinson's disease, Hum Brain Mapp.

10.1002/mds.22799

10.1016/j.neuroimage.2007.07.007

10.1016/j.neuroimage.2005.02.018

Association AP, 1994, Diagnostic and Statistical Manual of Mental Disorders, Association AP.

10.1006/jmrb.1994.1037

10.1002/mds.25272

10.1002/mds.20704

10.1136/jnnp.2006.093849

10.1038/nrneurol.2011.21

10.1093/brain/awh493

10.1016/S0304-3940(99)00208-6

10.1093/brain/awh088

10.1002/mds.20652

10.1002/mds.21453

10.1007/s00401-009-0620-2

10.1016/j.cogbrainres.2005.01.023

10.1002/mds.22867

10.1177/1533317512470207

10.1212/WNL.55.11.1621

10.1002/mds.21844

10.1016/S1474-4422(03)00351-X

10.1111/j.2044-8341.1959.tb00467.x

10.1002/hbm.21245

10.1002/mds.21956

10.1212/01.wnl.0000304050.05332.9c

10.3174/ajnr.A0850

10.1016/S0022-510X(03)00037-6

10.1016/S1474-4422(10)70212-X

10.1002/mds.22858

10.1136/jnnp.2009.184747

10.1212/WNL.0b013e3181ff96bf

Lee SJ, 2010, Influence of white matter hyperintensities on the cognition of patients with Parkinson disease, Alzheimer Dis Assoc Disord, 24, 227, 10.1097/WAD.0b013e3181d71a13

10.1002/mds.24893

10.1111/j.1600-0404.2006.00795.x

10.1016/j.ymeth.2009.10.003

10.1136/jnnp-2011-300828

10.1002/gps.1610

10.1212/01.WNL.0000149510.41793.50

10.1002/hbm.1058

10.1001/archneur.1992.00530360060019

10.1002/hbm.21378

10.1001/archneur.56.3.303

10.1148/radiology.201.3.8939209

10.1016/j.neuroimage.2012.06.012

10.1007/s00415-005-0864-2

Rey A, 1964, L'examen Clinique en Psychologie

10.1016/j.neuroimage.2008.03.061

10.1016/j.neuroimage.2006.02.024

10.1073/pnas.240460497

10.1016/j.parkreldis.2009.11.002

10.1002/mds.23477

10.1118/1.598130

10.1001/archneur.62.2.281

10.1212/01.WNL.0000153070.82309.D4

10.1016/S1353-8020(08)70039-7

10.1093/brain/awm111

10.1093/brain/awm313

10.1016/j.neuropsychologia.2005.03.013

Thông tin
Thông tin xuất bản

Human Brain Mapping

Tập 35 Số 5

1921-1929

Thông tin tác giả