Microtubule actin cross‐linking factor 1, a novel potential target in cancer

Cancer Science - Tập 108 Số 10 - Trang 1953-1958 - 2017
Zhiping Miao1,2, Arshad Ali1,2, Lifang Hu1,2, Fan Zhao1,2, Chong Yin1,2, Chu Chen3, Tuanmin Yang3, Airong Qian1,2
1Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China
2Shenzhen Research Institution of Northwestern Polytechnical University, Shenzhen, China
3Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China

Tóm tắt

Cancer is a polygenic disease characterized by uncontrolled growth of normal body cells, deregulation of the cell cycle as well as resistance to apoptosis. The spectraplakin protein microtubule actin cross‐linking factor 1 (MACF1) plays an essential function in various cellular processes, including cell proliferation, migration, signaling transduction and embryo development. MACF1 is also involved in processes such as metastatic invasion in which cytoskeleton organization is a critical element that contributes to tumor progression in various human cancers. Aberrant expression of MACF1 initiates the tumor cell proliferation, and migration and metastasis in numerous cancers, such as breast cancer, colon cancer, lung cancer and glioblastoma. In this review, we summarized the current knowledge of MACF1 and its critical role in different human cancers. This will be helpful for researchers to investigate the novel functional role of MACF1 in human cancers and as a potential target to enhance the efficacy of therapeutic treatment modalities.

Từ khóa


Tài liệu tham khảo

10.1016/S0092-8674(00)80041-0

10.3390/cancers9050044

Hu L, 2017, MACF1, versatility in tissue‐specific function and in human disease, Semin Cell Dev Biol, pii: S1084‐9521

10.5483/BMBRep.2016.49.1.185

10.1007/s12035-015-9508-4

10.1006/geno.1996.0587

10.1083/jcb.147.6.1275

10.1006/bbrc.1999.1538

10.1074/jbc.274.47.33522

10.1007/s00335-001-3037-3

10.1083/jcb.149.1.195

10.1016/0014-5793(95)00722-L

10.1002/1097-0177(2000)9999:9999<::AID-DVDY1041>3.0.CO;2-O

10.1242/jcs.02510

10.1016/j.mcn.2010.01.010

10.1016/S0959-437X(97)80154-2

10.1016/j.yexcr.2007.03.039

10.1016/j.jprot.2009.12.004

10.1016/j.cell.2010.12.033

10.1016/j.cell.2008.07.045

10.1073/pnas.1000975107

10.1074/jbc.M112.431825

10.5483/BMBRep.2015.48.10.098

10.1002/bem.20511

10.1016/S0092-8674(03)00813-4

10.1101/gad.1411206

10.1083/jcb.122.2.461

10.1016/j.ydbio.2014.09.009

10.1002/jcp.26059

10.1016/j.devcel.2012.04.019

10.1016/j.bbrc.2014.11.071

10.1093/neuonc/nou223

10.1093/neuonc/nou087

10.1126/science.1164382

10.1016/j.ccr.2009.12.020

10.1158/1078-0432.CCR-04-1737

10.1200/JCO.2006.08.0705

10.1056/NEJMoa043331

10.1093/neuonc/nop020

10.1016/j.spen.2014.12.005

10.3892/ijo.2016.3798

10.1016/j.yexcr.2010.02.011

10.3322/caac.20107

10.1089/gtmb.2010.0158

10.1126/science.3798106

10.1126/science.1133427

10.1016/j.tcb.2004.12.006

10.1016/j.cell.2011.01.023

10.1101/gad.10.14.1724

10.1073/pnas.95.19.11312

10.1038/ng0896-450

10.1111/j.1600-0625.1996.tb00124.x

10.1371/journal.pone.0067552

10.1128/MCB.00709-10

10.1158/1535-7163.MCT-09-0282

10.1172/JCI116462

10.1038/jid.2013.498

10.1016/0092-8674(92)90611-F

10.3892/ijmm.2013.1284

Thông tin
Thông tin xuất bản

Cancer Science

Tập 108 Số 10

1953-1958

Thông tin tác giả